Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle

Abstract

A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.

1 . A method for treating a spastic muscle, the method comprising the step of administering to a patient a therapeutically effective amount of the neurotoxic component of a botulinum toxin to thereby treat the spastic muscle, wherein the neurotoxic component administered to the patient has been purified from a botulinum toxin obtained by fermenting  Clostridium botulinum.    
     
     
         2 . The method of  claim 1  wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C, D, E, F and G. 
     
     
         3 . The method of  claim 1  wherein the botulinum toxin is botulinum toxin type A. 
     
     
         4 . The method of  claim 1  wherein the neurotoxic component has a molecular weight of about 150 kilodaltons. 
     
     
         7 . The method of  claim 1  wherein the neurotoxic component is administered by intramuscular injection. 
     
     
         8 . The method of  claim 1  wherein the spastic muscle is a facial muscle. 
     
     
         9 . The method of  claim 1  wherein the spastic muscle is a jaw muscle. 
     
     
         10 . The method of  claim 1  wherein the spastic muscle is a throat muscle. 
     
     
         11 . The method of  claim 1  wherein the spastic muscle is a vocal chord muscle. 
     
     
         12 . The method of  claim 1  wherein the spastic muscle is a leg muscle. 
     
     
         13 . The method of  claim 12  wherein the spastic muscle is a thigh muscle. 
     
     
         14 . The method of  claim 1  wherein the spastic muscle is a hand muscle. 
     
     
         15 . The method of  claim 1  wherein the spastic muscle is a wrist muscle. 
     
     
         16 . The method of  claim 1  wherein the spastic muscle is a forearm muscle. 
     
     
         17 . The method of  claim 1  wherein the spastic muscle is a smooth muscle. 
     
     
         18 . The method of  claim 17  wherein the smooth muscle is a sphincter. 
     
     
         19 . The method of  claim 18  wherein the smooth muscle sphincter is a gastrointestinal system smooth muscle sphincter. 
     
     
         20 . The method of  claim 18  wherein the smooth muscle sphincter is a urinary smooth muscle sphincter. 
     
     
         21 . The method of  claim 18  wherein the smooth muscle sphincter is a rectal sphincter. 
     
     
         22 . A method for treating a spastic muscle, the method comprising the step of administering to a patient a therapeutically effective amount of the neurotoxic component of only a botulinum toxin type A, to thereby treat the spastic muscle, wherein the neurotoxic component administered to the patient has been purified from a botulinum toxin obtained by fermenting  Clostridium botulinum.    
     
     
         23 . The method of  claim 22  wherein the neurotoxic component has a molecular weight of about 150 kilodaltons. 
     
     
         24 . The method of  claim 22  wherein the neurotoxic component is administered by intramuscular injection. 
     
     
         25 . The method of  claim 22  wherein the spastic muscle is a facial muscle. 
     
     
         26 . The method of  claim 22  wherein the spastic muscle is a jaw muscle. 
     
     
         27 . The method of  claim 22  wherein the spastic muscle is a throat muscle. 
     
     
         28 . The method of  claim 22  wherein the spastic muscle is a vocal chord muscle. 
     
     
         29 . The method of  claim 22  wherein the spastic muscle is a leg muscle. 
     
     
         30 . The method of  claim 29  wherein the spastic muscle is a thigh muscle. 
     
     
         31 . The method of  claim 22  wherein the spastic muscle is a hand muscle. 
     
     
         32 . The method of  claim 22  wherein the spastic muscle is a wrist muscle. 
     
     
         33 . The method of  claim 22  wherein the spastic muscle is a forearm muscle. 
     
     
         34 . The method of  claim 22  wherein the spastic muscle is a smooth muscle. 
     
     
         35 . The method of  claim 34  wherein the smooth muscle is a sphincter. 
     
     
         36 . The method of  claim 35  wherein the smooth muscle sphincter is a gastrointestinal system smooth muscle sphincter. 
     
     
         37 . The method of  claim 35  wherein the smooth muscle sphincter is a urinary smooth muscle sphincter. 
     
     
         38 . The method of  claim 35  wherein the smooth muscle sphincter is a rectal sphincter. 
     
     
         39 . A method for treating a spastic muscle, the method comprising the step of administering to a patient a therapeutically effective amount of the neurotoxic component from a single botulinum toxin type selected from the group consisting of the botulinum toxin types A, B, C, D, E, F and G to thereby treat the spastic muscle, wherein the neurotoxic component administered to the patient has been purified from a botulinum toxin obtained by fermenting a  Clostridium botulinum  bacterium. 
     
     
         40 . The method of  claim 39  wherein the neurotoxic component has a molecular weight of about 150 kilodaltons. 
     
     
         41 . The method of  claim 39 , wherein the neurotoxic component is administered by intramuscular injection. 
     
     
         42 . The method of  claim 39  wherein the spastic muscle is a facial muscle. 
     
     
         43 . The method of  claim 39  wherein the spastic muscle is a jaw muscle. 
     
     
         44 . The method of  claim 39  wherein the spastic muscle is a throat muscle. 
     
     
         45 . The method of  claim 39  wherein the spastic muscle is a vocal chord muscle. 
     
     
         46 . The method of  claim 39  wherein the spastic muscle is a leg muscle. 
     
     
         47 . The method of  claim 46  wherein the spastic muscle is a thigh muscle. 
     
     
         48 . The method of  claim 39  wherein the spastic muscle is a hand muscle. 
     
     
         49 . The method of  claim 39  wherein the spastic muscle is a wrist muscle. 
     
     
         50 . The method of  claim 39  wherein the spastic muscle is a forearm muscle. 
     
     
         51 . The method of  claim 39  wherein the spastic muscle is a smooth muscle. 
     
     
         52 . The method of  claim 51  wherein the smooth muscle is a sphincter. 
     
     
         53 . The method of  claim 52  wherein the smooth muscle sphincter is a gastrointestinal system smooth muscle sphincter. 
     
     
         54 . The method of  claim 52  wherein the smooth muscle sphincter is a urinary smooth muscle sphincter. 
     
     
         55 . The method of  claim 52  wherein the smooth muscle sphincter is a rectal sphincter. 
     
     
         56 . The method of  claim 39  wherein the botulinum toxin is a botulinum toxin type A.