Methods for administering weight loss medications

Abstract

Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.

1 . A unit dosage package for a pharmaceutical formulation, comprising:
 a first unit dosage comprising a first drug and a second drug;   a second unit dosage comprising said first drug and said second drug, wherein said second unit dosage comprises a different amount of said second drug than said first unit dosage; and   a unit dosage package configured to hold said first unit dosage and said second unit dosage.   
   
   
       2 . The unit dosage package of  claim 1 , wherein said second unit dosage comprises a greater amount of said second drug than said first unit dosage. 
   
   
       3 . The unit dosage package of  claim 1 , wherein said first drug or said second drug comprises an antidepressant. 
   
   
       4 . The unit dosage package of  claim 3 , wherein said antidepressant comprises bupropion. 
   
   
       5 . The unit dosage package of  claim 4 , wherein said bupropion comprises a sustained-release bupropion. 
   
   
       6 . The unit dosage package of  claim 1 , wherein said first drug or said second drug comprises an anticonvulsant. 
   
   
       7 . The unit dosage package of  claim 6 , wherein said anticonvulsant comprises zonisamide. 
   
   
       8 . The unit dosage package of  claim 7 , wherein said zonisamide comprises a sustained-release zonisamide. 
   
   
       9 . The unit dosage package of  claim 1 , wherein said first drug or said second drug comprises an opioid antagonist. 
   
   
       10 . The unit dosage package of  claim 9 , wherein said opioid antagonist comprises naltrexone. 
   
   
       11 . The unit dosage package of  claim 1 , wherein said first drug comprises bupropion and said second drug comprises zonisamide. 
   
   
       12 . The unit dosage package of  claim 1 , wherein said first drug comprises bupropion and said second drug comprises naltrexone. 
   
   
       13 . The unit dosage package of  claim 1 , wherein said first drug comprises fluoxetine and said second drug comprises naltrexone. 
   
   
       14 . The unit dosage package of  claim 1 , wherein said first drug comprises olanzapine and said second drug comprises zonisamide. 
   
   
       15 . The unit dosage package of  claim 1 , wherein said first drug comprises antidiabetic and said second drug comprises zonisamide. 
   
   
       16 . The unit dosage package of  claim 15 , wherein said antidiabetic comprises metformin. 
   
   
       17 . The unit dosage package of  claim 1 , wherein said first drug comprises topiramate and said second drug comprises phentermine. 
   
   
       18 . The unit dosage package of  claim 1 , wherein said unit dosage package comprises a blister and said blister holds both said first drug and said second drug. 
   
   
       19 . The unit dosage package of  claim 1 , wherein said first drug and said second drug are selected from the group consisting of zonisamide, bupropion, naltrexone, phentermine, topiramate, metformin, olanzapine, fluoxetine, and any combinations, prodrugs or salts thereof. 
   
   
       20 . The unit dosage package of  claim 19 , wherein said first drug and said second drug are part of a single physical form. 
   
   
       21 . The unit dosage package of  claim 20 , wherein said single physical form is a multi-layer tablet. 
   
   
       22 . The unit dosage package of  claim 21 , wherein said multi-layer tablet is a trilayer tablet. 
   
   
       23 . The unit dosage package of  claim 1 , wherein said unit dosage package comprises a first blister and a second blister, wherein said first blister holds said first drug and said second blister holds said second drug. 
   
   
       24 . The unit dosage package of  claim 1 , wherein said unit dosage package comprises a blister pack. 
   
   
       25 . A method of packaging a combination of bupropion and at least one of zonisamide and naltrexone, comprising:
 providing a unit dosage package that holds said bupropion and said at least one of said zonisamide and said naltrexone; and   packaging administration instructions with said unit dosage package in a unit dosage package.   
   
   
       26 . The method of  claim 25 , wherein said bupropion comprises a sustained-release bupropion. 
   
   
       27 . The method of  claim 25 , wherein said zonisamide comprises a sustained-release zonisamide. 
   
   
       28 . The method of  claim 25 , wherein said naltrexone comprises a sustained-release naltrexone. 
   
   
       29 . The method of  claim 25 , wherein packaging administration instructions in said unit dosage package comprises printing instructions onto said unit dosage package. 
   
   
       30 . The method of  claim 25 , wherein said unit dosage package comprises a blister pack. 
   
   
       31 . A method of providing a pharmaceutical formulation to a patient, said method comprising:
 providing a unit dosage package for a pharmaceutical formulation,   wherein the unit dosage package is configured to hold a first unit dosage and a second unit dosage,   wherein the first unit dosage comprises a first drug and a second drug,   wherein the second unit dosage comprises the first drug and the second drug, and   wherein the second unit dosage comprises a different amount of the second drug than the first unit dosage.   
   
   
       32 . The method of  claim 31  further comprising identifying a patient with an obesity related condition, wherein said obesity-related condition is selected from the group consisting of obesity, hypertension, diabetes, dyslipidaemia, weight gain associated with smoking cessation and weight gain associated with use of a psychotherapeutic drug. 
   
   
       33 . The method of  claim 31 , wherein said second dosage comprises a greater amount of said second drug than said first dosage. 
   
   
       34 . The method of  claim 31 , wherein said first drug or said second drug comprises an antidepressant. 
   
   
       35 . The method of  claim 31 , wherein said first drug or said second drug comprises an anticonvulsant. 
   
   
       36 . The method of  claim 31 , wherein said first drug or said second drug comprises an opioid antagonist. 
   
   
       37 . The method of  claim 31 , wherein said first drug or said second drug comprises an antidiabetic. 
   
   
       38 . The method of  claim 31 , wherein said first drug and said second drug are selected from the group consisting of zonisamide, bupropion, naltrexone, phentermine, topiramate, antidiabetic, olanzapine, fluoxetine, and any combinations, prodrugs or salts thereof. 
   
   
       39 . The method of  claim 31  further comprising identifying the patient as being at risk of suffering an adverse side effect from administration of an anticonvulsant. 
   
   
       40 . The method of  claim 31  further comprising identifying the patient as being at risk of suffering an adverse side effect from administration of an opioid antagonist. 
   
   
       41 . The method of  claim 31  further comprising opening a unit dosage package, the unit dosage package comprising said first dosage and said second dosage. 
   
   
       42 . The method of  claim 31 , wherein said unit dosage package comprises a blister pack. 
   
   
       43 . The method of  claim 31 , wherein the unit dosage package comprises a third unit dosage and, wherein said third dosage comprises a greater amount of said second drug than said second dosage. 
   
   
       44 . The method of  claim 31 , wherein providing the unit dosage package comprises removing said first dosage and said second dosage from the unit dosage package. 
   
   
       45 . The method of  claim 31 , wherein providing a unit dosage package comprises administering a tablet that comprises said first drug and said second drug to said patient, wherein the tablet comprises a plurality of layers. 
   
   
       46 . The method of  claim 45 , wherein said tablet is a trilayer tablet.