Recombinant Herpesvirus Useful in Vaccine Production

Abstract

The present invention provides a novel avian herpesvirus (NAHV) vector and recombinant vaccines made therefrom that are useful to immunize avian species against Marek's disease, infectious laryngotracheitis and Newcastle disease. Methods of immunizing an avian species against Marek's disease, infectious laryngotracheitis and Newcastle disease are also provided.

1 - 39 . (canceled)  
     
     
         40 . A recombinant avian, herpesvirus comprising a US2 gene in which a foreign DNA sequence has been inserted; wherein said foreign DNA sequence is capable of being expressed in a host cell that has been infected by said recombinant avian herpesvirus.  
     
     
         41 . The recombinant avian herpesvirus of  claim 40 , wherein said foreign DNA sequence is selected from the group consisting of the Newcastle disease virus fusion gene, the infectious laryngotracheitis virus glycoprotein D gene, and the infectious laryngotracheitis virus glycoprotein I gene.  
     
     
         42 . The recombinant avian herpesvirus of  claim 40  wherein said foreign DNA sequence is the Newcastle disease virus fusion gene.  
     
     
         43 . The recombinant avian herpesvirus of  claim 40  wherein said foreign DNA sequence is the infectious laryngotracheitis virus glycoprotein D gene.  
     
     
         44 . The recombinant avian herpesvirus of  claim 40  wherein said foreign DNA sequence is the infectious laryngotracheitis virus glycoprotein gene.  
     
     
         45 . The recombinant avian herpesvirus of  claim 40  wherein said foreign DNA sequence is the infectious laryngotracheitis virus glycoprotein D gene and the infectious laryngotracheitis virus glycoprotein I gene.  
     
     
         46 . A vaccine for protecting against Newcastle disease comprising an effective immunizing amount of the recombinant avian herpesvirus of  claim 42  and a suitable carrier.  
     
     
         47 . A vaccine for protecting against infectious laryngotracheitis virus comprising an effective immunizing amount of the recombinant avian herpesvirus of  claim 45  and a suitable carrier.