Method for preventing the adhesion of particles

Abstract

A method for the prevention of the adhesion of particles, in particular cells and cellular components in solution to surfaces, characterized in that to the solution is added at least one polyalcohol.

1 . A method for for inhibiting adhesion of particles to surfaces, said method comprising:
 providing particles comprising cellular components;   providing a substrate comprising a microanalysis system or synthetic microparticles, wherein the substrate has surfaces to which the particles are capable of adhering;   providing the particles in a solution comprising polyvinyl alcohol; and   contacting the substrate with the solution, wherein the polyvinyl alcohol is present as a solute in the solution in an amount effective to inhibit adhesion of the particles to the surfaces;   wherein the concentration of the polyvinyl alcohol in solution is 0.01% (w/v) to 5% (w/v).   
     
     
         2 . (canceled) 
     
     
         3 . (canceled) 
     
     
         4 . (canceled) 
     
     
         5 . (canceled) 
     
     
         6 . The method according to  claim 1 , characterized in that the cellular components involve liposomes, lipid membranes, lipids, proteins, DNA, nucleic acids, messenger substances, sugar, glycans, and/or glycoproteins. 
     
     
         7 . The method according to  claim 1 , characterized in that the surfaces involve cell membranes, cellular components, uncoated or with biomolecules coated surfaces from silicon, silicone, organic polymers, and/or glass. 
     
     
         8 . The method according to  claim 7 , characterized in that the biomolecules are lipid membranes, lipids, proteins (in particular antibodies), DNA, nucleic acids, messenger substances, biotin, sugar, glycans, and/or glycoproteins. 
     
     
         9 . The method according to  claim 7 , characterized in that the organic polymers are PMMA, polyurethane, polycarbonate, polypropylene, polystyrene, polyethylene, polyvinyl chloride, Teflon®, polyacryl, nylon®, and/or perlon®. 
     
     
         10 . The method according to  claim 1 , characterized in that the surfaces involve channel surfaces of a microanalysis system. 
     
     
         11 . The method according to  claim 1 , characterized in that the surfaces involve surfaces of synthetic microparticles. 
     
     
         12 . (canceled) 
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . (canceled)