Povidone-Containing Carriers for Polypeptide Growth Factors

Abstract

A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic tissues. The liquid medium comprises an aqueous solution of polyvinyl pyrrolidone.

1 - 31 . (canceled)  
     
     
         32 . A method of promoting soft tissue regeneration in a living subject, comprising: 
 administering to the soft tissue a growth factor composition comprising a polypeptide of the TGF-β superfamily and a carrier comprising a vinyl pyrrolidone polymer having a molecular weight of from about 2.5 kD to about 20 kD and a solvent selected from the group consisting of water and aqueous buffer solutions,    wherein the weight ratio of the polypeptide to the vinyl pyrrolidone polymer is 1:10 or less and angiogenesis is induced in the soft tissue.    
     
     
         33 . The method of  claim 32 , wherein the soft tissue comprises myocardial tissue.  
     
     
         34 . The method of  claim 33 , wherein administering comprises injecting the composition into the myocardial tissue.  
     
     
         35 . The method of  claim 34 , wherein the composition is a liquid having a viscosity of less than about 3 cP.