Tgfbeta Supported and Binding Peptides

Abstract

The present invention provides peptides and supported peptides that bind TGFβ (molecules. In some particularly preferred embodiments, the TGFβ binding molecules bind TGFβ-1, while in other embodiments, the TGFβ binding molecules bind TGFβ-2.

1 . A composition comprising at least one peptide selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, and 16, wherein said peptide binds to a transforming growth factor. 
     
     
         2 . The composition of  claim 1 , wherein said peptide is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOS:1, 3, 5, 7, 9, 11, 13, and 15. 
     
     
         3 . The composition of  claim 1 , wherein said peptide is expressed in a protease resistant scaffold. 
     
     
         4 . The composition of  claim 3 , wherein said scaffold is a protease inhibitor. 
     
     
         5 . The composition of  claim 4 , wherein said protease inhibitor is selected from the group consisting of Bowman-Birk Inhibitor, soybean trypsin inhibitor, and Eglin chymotrypsin inhibitor. 
     
     
         6 . The composition of  claim 3 , wherein said protease resistant scaffold and said peptide comprise a fusion protein. 
     
     
         7 . A cosmetic or pharmaceutical composition comprising said at least one peptide of  claim 1 . 
     
     
         8 . The composition of  claim 7 , wherein said composition is capable of modulating hair growth. 
     
     
         9 . The composition of  claim 6 , wherein said composition further comprises a scaffold. 
     
     
         10 . A method for modulating hair growth comprising:
 i) providing a composition comprising a peptide contained within a scaffold;   ii) providing a subject to be treated; and   iii) applying said composition to said subject in an area in which hair growth modulation is desired.   
     
     
         11 . The method of  claim 10 , wherein said peptide binds to a transforming growth factor-beta (TGFβ). 
     
     
         12 . The method of  claim 11 , wherein said TGFβ is selected from the group consisting of TGFβ-1 and TGFβ-2. 
     
     
         13 . The method of  claim 10 , wherein said scaffold is selected from the group consisting of Bowman-Birk inhibitor, soybean trypsin inhibitor, and Eglin chymotrypsin inhibitor. 
     
     
         14 . The method of  claim 10 , wherein said peptide is selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, and 16. 
     
     
         15 . The method of  claim 10 , wherein said peptide is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOS:1, 3, 5, 7, 9, 11, 13, and 15. 
     
     
         16 . A method for decreasing the activity of a transforming growth factor comprising the steps of:
 i) providing a subject; and   ii) administering the composition of  claim 1  to said subject, under conditions such that the activity of said transforming growth factor is decreased.   
     
     
         17 . The method of  claim 16 , wherein said transforming growth factor is selected from the group consisting of TGFβ-1 and TGFβ-2. 
     
     
         18 . A composition comprising at least one TGFβ-1 peptide sequence selected from the group of SEQ ID NOS:2, 4, 6, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, and 34. 
     
     
         19 . A composition comprising at least one TGFβ-2 peptide sequence selected from the group of SEQ ID NOS:8, 10, 12, 14, and 16.