Methods for diagnosis and treatment of PH domain signal transduction disorders

Abstract

Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a PH domain and a PH domain binding partner.

1 . Composition for treatment of a disease or condition characterized by an abnormality in a signal transduction pathway, wherein said signal transduction pathway involves the interaction between a PH domain and a PH domain binding partner, comprising a therapeutically effective amount of a specific PH domain binding partner and a pharmaceutically acceptable carrier or diluent.  
     
     
         2 . The composition of  claim 1 , wherein said binding partner has submicromolar affinity for a PH domain.  
     
     
         3 . The composition of  claim 1 , wherein said binding partner is an antagonist.  
     
     
         4 . The composition of  claim 1 , wherein said binding partner is an agonist.  
     
     
         5 . The composition of  claim 1 , wherein said binding partner is a ligand.  
     
     
         6 . Composition for treatment of a disease or condition characterized by an abnormality in a signal transduction pathway, wherein said signal transduction pathway involves the interaction between a PH, domain and a PH domain binding partner, comprising a therapeutically effective amount of a mimetic of a specific PH domain binding partner and a pharmaceutically acceptable carrier or diluent.  
     
     
         7 . The composition of  claim 5 , wherein said binding partner has submicromolar affinity for a PH domain.