US2008118510A1PendingUtilityA1

Vegf-related protein

66
Assignee: LEE JAMESPriority: Sep 8, 1995Filed: Jan 14, 2008Published: May 22, 2008
Est. expirySep 8, 2015(expired)· nominal 20-yr term from priority
Inventors:James LeeWilliam I. Wood
A61P 9/10A61P 5/14A61P 9/14A61P 3/10A61P 9/00A61P 7/10A61P 43/00A61P 7/00A61P 35/00A61P 35/04A61P 29/00A61P 27/06A61P 27/02C07K 2319/00C07K 16/22A61P 19/02A61P 17/02A61P 17/06C07K 14/52C07K 14/71C07K 2319/30A61P 11/00A61K 38/00A61P 17/00A61P 13/12
66
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Claims

Abstract

A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.

Claims

exact text as granted — not AI-modified
1 . A method of inhibiting angiogenesis in a mammal, said method comprising: 
 administering to the mammal an effective amount of an anti-VEGF-related protein (VRP) antibody in combination with an anti-VEGF antibody.    
     
     
         2 . The method of  claim 1 , where in the anti-VRP antibody is a monoclonal antibody.  
     
     
         3 . The method of  claim 1  or  2 , wherein the anti-VRP antibody is a humanized antibody.  
     
     
         4 . The method of  claim 1 , wherein the mammal is a human.  
     
     
         5 . A method of inhibiting endothelial cell growth in a mammal, said method comprising administering to the mammal an effective amount of an anti-VEGF-related protein (VRP) antibody in combination with an anti-VEGF antibody.  
     
     
         6 . The method of  claim 5 , where in the anti-VRP antibody is a monoclonal antibody.  
     
     
         7 . The method of  claim 5  or  6 , wherein the anti-VRP antibody is a humanized antibody.  
     
     
         8 . The method of  claim 5 , wherein the mammal is a human.  
     
     
         9 . A method of inhibiting tumor growth in a mammal, said method comprising administering to the mammal an effective amount of an anti-VEGF-related protein (VRP) antibody in combination with an anti-VEGF antibody.  
     
     
         10 . The method of  claim 9 , where in the anti-VRP antibody is a monoclonal antibody.  
     
     
         11 . The method of  claim 9  or  10 , wherein the anti-VRP antibody is a humanized antibody.  
     
     
         12 . The method of  claim 9 , wherein the mammal is a human.

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