US2008119488A1PendingUtilityA1
Modulators Of Nuclear Receptors

Assignee: EXELIXIS INCPriority: Jul 24, 2004Filed: Jul 24, 2005Published: May 22, 2008
Est. expiryJul 24, 2024(expired)· nominal 20-yr term from priority
Inventors:Christopher D. Bayne Alan T. Johnson Shao-Po Lu Raju Mohan Michael Charles Nyman Edwin Schweiger William C. Stevens, Jr.Haixia Wang Yinong Xie Lynne Canne Bannen Diva Sze-Ming Chan Ping Huang Vasu Jammalamadaka Richard George Khoury Morrison B. Mac Jason Jevious Parks Yong Wang Wei Xu
A61P 3/10A61P 43/00A61P 9/00A61P 9/10A61P 37/02A61P 3/06A61P 25/28A61P 29/00A61P 25/16A61P 3/00A61P 35/00A61P 3/04A61P 25/00C07D 417/04C07D 405/12C07D 401/14C07D 417/12A61P 17/10A61P 17/00C07D 413/06C07D 417/06C07D 401/12C07D 401/10C07D 405/04C07D 405/06C07D 409/06C07D 401/04A61P 1/16C07D 213/84C07D 409/04C07D 401/06A61P 17/02C07D 409/14C07D 405/14C07D 213/85
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Claims
Abstract

Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
Claims

exact text as granted — not AI-modified
1 . A compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         n is 1 to 4; 
         m is 1 to 4; 
       
       
         
           
           
               
               
           
         
         is aryl or heteroaryl; 
       
       
         
           
           
               
               
           
         
         is aryl, heterocyclyl or heteroaryl; 
         R 1  is hydrogen, optionally substituted aralkyl or optionally substituted heteroarylalkyl; 
         R 2  is hydrogen, cyano, —R 7 —C(O)OR 8 , —R 7 —N(R 8 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ; 
         R 3  is hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, optionally substituted aralkyl, optionally substituted aralkenyl, haloalkyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl; 
         each R 4  is independently hydrogen, halo, alkyl, haloalkyl, cyano, —OR 8 , —N(R 8 ) 2 ; 
         each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, haloalkyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —OR 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 8 ) 2 , —R 7 , —C(O)N(R 8 )OR 11 —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(O)N(R 8 )—R 9 —OR 11 , —R 7 —C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )—R 9 —C(O)OR 10 , —R 7 —N(R 8 )C(O)R 8 —R 7 —N(R 8 )C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 )—OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 11 , —R 7 —N(R 8 )C(O)C(O)N(R 11 ) 2 , —R 7 —N(R)C(O)C(O)OR 11 , —R 7 —N(R 8 )S(O) 2 —R 8 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ; 
         R 6  is —OR 7 —, —N(R 8 )—, a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyalkenyl, optionally substituted haloalkyl, optionally substituted haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         each R 10  is independently selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl; 
         as an isomer, a mixture of stereoisomers, a racemic mixture thereof of stereoisomers, or as a tautomer; 
         or as a pharmaceutically acceptable salt, prodrug, solvate or polymorph thereof. 
       
     
     
         2 . The compound of  claim 1  having the following formula (II): 
       
         
           
           
               
               
           
         
         wherein: 
         n is 1 to 4; 
         m is 1 to 4; 
         R 1  is hydrogen, optionally substituted aralkyl or optionally substituted heteroarylalkyl; 
         R 2  is hydrogen, cyano or —R 7 —N(R 8 ) 2 ; 
         R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl; 
         each R 4  is independently hydrogen, halo, alkyl, haloalkyl, cyano, —OR 8 , —N(R 8 ) 2 ; 
         each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, haloalkyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 11 )OR 11 , —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 11 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(O)N(R 8 )—R 9 —OR 11 , —R 7 —C(O)N(R 8 )—R 9 —N(R 8 ) 2 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )—R 9 —C(O)OR 8 , —R 7 —N(R 8 )C(O)R 8 , —R 7 —N(R 8 )C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 )—OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 11 , —R 7 —N(R 7 )C(O)C(O)N(R 11 ) 2 , —R 7 —N(R 8 )C(O)C(O)OR 8 , —R 7 —N(R 8 )S(O) 2 —R 8 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ; 
         R 6  is —OR 7 —, a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyalkenyl, optionally substituted haloalkyl, optionally substituted haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         each R 10  is independently selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl. 
       
     
     
         3 . The compound of  claim 2  wherein:
 n is 1;   m is 1 or 2;   R 1  is optionally substituted aralkyl or optionally substituted heteroarylalkyl;   R 2  is cyano;   R 3  is alkyl, hydroxyalkyl, or haloalkyl;   R 4  is hydrogen, halo, alkyl or haloalkyl;   each 1R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, haloalkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —R 7 —CN, —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 11 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ;   R 6  is —OR 7 —, a direct bond, a straight or branched alkenylene chain or a straight or branched alkynylene chain;   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted haloalkyl, optionally substituted haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;   each R 9  is a straight or branched alkylene chain optionally substituted by aryl or heteroaryl;   R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         4 . The compound of  claim 3  wherein R 6  is —OR 7 —. 
     
     
         5 . The compound of  claim 4  wherein R 1  is aralkyl or heteroarylalkyl each independently optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8 , —N(R 8 ) 2  or NR 8 C(O)OR 10 . 
     
     
         6 . The compound of  claim 5  wherein:
 n is 1;   m is 1 or 2;   R 2  is cyano;   R 3  is methyl, ethyl, 1-hydroxy-1-methylethyl, fluoromethyl, difluoromethyl, pentafluoroethyl or trifluoromethyl;   R 4  is hydrogen, methyl, 1-methylethyl or chloro;   each R 5  is independently selected from the group consisting of hydrogen, halo, alkyl, alkenyl or haloalkyl.   
     
     
         7 . The compound of  claim 6  wherein each R 5  is independently selected from hydrogen, chloro, bromo, fluoro, methyl, ethyl, 1-methylethyl, 1,1-dimethylethyl, ethenyl or trifluoromethyl. 
     
     
         8 . The compound of  claim 7  selected from the group consisting of the following: 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3-isopropyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-tert-Butyl-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-fluoro-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2,4-dimethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2,5-dimethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2,6-dimethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(2-Chloro-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[3-methyl-4-(2-trifluoromethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[3-methyl-4-(3-trifluoromethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Bromo-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Bromo-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Benzyloxy-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2,4-dimethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(4-Benzyloxy-phenyl)-1-(2,4-dichloro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-phenoxy-phenyl-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-4-fluoro-benzyl)-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(4-Benzyloxy-phenyl)-1-(2-chloro-4-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-2-oxo-4-pentafluoroethyl-6-(4-phenoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-phenoxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-o-tolyloxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4 (2-ethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2,5-dimethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2,4-dimethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Diethyl-benzyl)-6-[4-(3,4-dimethyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-m-tolyloxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(3-isopropyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(4-isopropyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-(3-isopropyl-4-p-tolyloxy-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-tert-Butyl-phenoxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(4-vinyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-ethyl-2-ethyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-ethyl-2-methyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2-ethyl-4-methyl-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(2-ethyl-4-methyl-phenoxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(4-Benzyloxy-3-chloro-phenyl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[3-Chloro-4-(4-fluoro-phenoxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluormethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         9 . The compound of  claim 5  wherein:
 n is 1;   m is 1 or 2;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen, methyl, 1-methylethyl or chloro;   each R 5  is independently selected from the group consisting of haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8  and R 7 —O—R 9 —C(O)OR 8 ,   each R 7  is independently selected from a direct bond or methylene chain;   each R 8  is independently selected from hydrogen, alkyl, aryl and aralkyl; and   R 9  is a methylene chain.   
     
     
         10 . The compound of  claim 9  selected from the group consisting of the following: 
       6-[4-(4-Dimethylamino-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-methoxy-phenoxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Cyano-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Benzyloxy-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Benzyloxy-phenoxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Cyano-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Cyano-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Dimethylamino-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-hexyloxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-{4-[4-(3-methyl-butoxy)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3-hexyloxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-{4 [3-(3-methyl-butoxy)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-phenoxy)-acetic acid benzyl ester; 
       (4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-phenoxy)-acetic acid benzyl ester; 
       1-(2,4-Dimethyl-benzyl)-2-oxo-6-[4-(4-phenylamino-phenoxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Benzylamino-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3-hydroxymethyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Benzyloxy-phenoxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Benzyloxy-phenoxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-hydroxy-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       6-[4-(3-Cyano-4-trifluoromethyl-phenoxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         11 . The compound of  claim 5  wherein:
 n is 1;   m is 1 or 2;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen, methyl, 1-methylethyl or chloro;   each R 5  is independently selected from the group consisting of heteroaryl, —R 7 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 , —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2  and —R 7 —S(O) t R 8  (where t is 0 to 2);   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, haloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl or heterocyclyl optionally substituted with hydroxy;   R 9  is a straight or branched alkylene chain (optionally substituted, by phenyl or imidazolyl); and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         12 . The compound of  claim 11  wherein:
 m is 1 or 2;   each R 5  is independently selected from —R 7 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8  or —R 7 —C(O)N(R 8 )N(R 8 ) 2 ;   each R 7  is independently selected from a direct bond or methylene;   each R 8  is independently selected from hydrogen, methyl, ethyl, 1,1-dimethylethyl, benzyl, 2-phenylethyl, cyclohexyl or piperidinyl optionally substituted by hydroxy; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         13 . The compound of  claim 12  selected from the group consisting of the following: 
       4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-2-methyl-phenoxy}-benzoic acid methyl ester; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-2-methyl-phenoxy}-benzoic acid methyl ester; 
       4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoic acid; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-methyl-benzamide; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide; 
       1-(2,4-Diethyl-benzyl)-2-oxo-6-{4-[3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-4-trifluoromethyl-1,2-dihydro pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-{4-[3-(3-hydroxy-piperidine-1-carbonyl)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       N-Benzyl-3-{4-[5-cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-3-benzamide; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoic acid N′-phenyl-hydrazide; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-cyclopentyl-benzamide; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-methoxy-N-methyl-benzamide; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-((S)-1-phenyl-ethyl)-benzamide; 
       3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N, N-dimethyl-benzamide; 
       3-Benzyloxy-5-{4-[5-cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-3-benzoic acid methyl ester; 
       3-Benzyloxy-5-{4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide; 
       3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-5-hydroxy-N,N-dimethyl-benzamide; 
       2-Benzyloxy-5-{4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-benzamide; 
       5-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-2-hydroxy-N,N-dimethyl-benzamide; 
       3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N-methyl-benzamide; 
       N-tert-Butyl-3-{4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzamide; and 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(piperidine-1-carbonyl)-phenoxy]-phenyl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         14 . The compound of  claim 5  wherein:
 n is 1;   m is 1 or 2;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen, methyl, 1-methylethyl or chloro;   each R 5  is independently selected from the group consisting of heteroaryl, —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2  and —R 7 —S(O) t R 8  (where t is 0 to 2);   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen alkyl, haloalkyl, aryl, aralkyl, aralkenyl, cycloalkyl or heterocyclyl; and   R 9  is a straight or branched alkylene chain (optionally substituted by phenyl or imidazolyl).   
     
     
         15 . The compound of  claim 14  wherein:
 n is 1;   m is 1;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen or chloro;   R 5  is —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 ;   R 7  is a direct bond;   each R 8  is independently hydrogen or alkyl; and   R 9  is a straight or branched alkylene chain optionally substituted by phenyl or imidazolyl.   
     
     
         16 . The compound of  claim 15  selected from the group consisting of the following: 
       (S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-propionic acid methyl ester; 
       (R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-propionic acid methyl ester; 
       (S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-methyl-butyric acid methyl ester; 
       (R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-methyl-butyric acid methyl ester; 
       (S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-4-methyl pentanoic acid methyl ester; 
       (R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-4-methylpentanoic acid methyl ester; 
       (S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-phenyl-propionic acid methyl ester; 
       (R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-phenyl-propionic acid methyl ester; 
       (S)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; 
       (R)-2-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl-phenoxy}-benzoylamino)-3-(1H-imidazol-4-yl]-propionic acid methyl ester; 
       (S)-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-phenyl-acetic acid methyl ester; and 
       (R)-(3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-benzoylamino)-phenyl-acetic acid methyl ester. 
     
     
         17 . The compound of  claim 14  wherein:
 n is 1;   m is 1;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen, methyl, 1-methylethyl or chloro;   each R 5  is independently selected from the group consisting of phthalimidyl, —R 7 —C(S)N(R 8 ) 2  and —R 7 —S(C)) t R 8  (where t is 0 or 2);   each R 7  is a direct bond; and   each R 8  is independently selected from hydrogen or alkyl.   
     
     
         18 . The compound of  claim 17  selected from the group consisting of the following: 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4-methylsulfanyl-phenoxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-{4-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-phenoxy]-phenyl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-thiobenzamide; and 
       6-[3-Chloro-4-(4-methanesulfonyl-phenoxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         19 . The compound of  claim 4  wherein R 1  is optionally substituted heteroarylalkyl. 
     
     
         20 . The compound of  claim 19  wherein:
 n is 1;   m is 1 or 2;   R 1  is optionally substituted thiazol-5-ylmethyl;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen, methyl, 1-methylethyl or chloro;   each R 5  is independently selected from the group consisting of hydrogen, halo, alkyl, alkenyl or haloalkyl.   
     
     
         21 . The compound of  claim 20 , i.e., namely 1-(2,5-Diethyl-thiazol-4-ylmethyl)-2-oxo-6-(4-phenoxy-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         22 . The compound of  claim 3  wherein:
 R 1  is aralkyl or heteroarylalkyl each independently optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8  or —N(R 8 ) 2 ;   each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 11 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ;   R 6  is a direct bond, a straight or branched alkenylene chain or a straight or branched alkynylene chain;   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or heterocyclyl;   each R 9  is a straight or branched alkylene chain optionally substituted by aryl or heteroaryl;   R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         23 . The compound of  claim 22  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents independently selected from alkylhalo or haloalkyl;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of alkyl, trifluoromethyl, —R 17 —OR and R 7 —S(O) t R 8  (where t is 0 to 2);   R 6  is a direct bond;   R 7  is a direct bond;   R 8  is hydrogen or alkyl; and   R 9  is a straight or branched alkylene chain.   
     
     
         24 . The compound of  claim 23  selected from the group consisting of the following: 
       1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-biphenyl-4-yl-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-ethylsulfanyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-ethanesulfonyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-methylsulfanyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(5′-methylsulfanyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-(4′-methylsulfanyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(5′-methylsulfanyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-3′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-methanesulfonyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(3′-methanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzil)-6-(3′-ethanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-2-sulfonyl)-5′-trifluoromethyl-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-ethoxy-3′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5′-(propane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-3-yl]-4-trifluoromethyl-2-dihydro-pyridine-3-carbonitrile; 
       6-[5′-(Butane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-3-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5′-phenylmethanesulfinyl-3′-trifluoromethyl-biphenyl-3-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(5′-Cyclopropylmethanesulfinyl-3′-trifluoromethyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5′-(propane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5′-(Butane-1-sulfinyl)-3′-trifluoromethyl-biphenyl-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5′-phenylmethanesulfinyl-3′-trifluoromethyl-biphenyl-4-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(5′-Cyclopropylmethanesulfinyl-3′-trifluoromethyl-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluorobenzyl)-6-(5′-ethanesulfinyl-3′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-2-sulfinyl)-5′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[3′-(Butane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-3-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[3′-(Butane-1-sulfonyl)-5′-trifluoromethyl-biphenyl-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3′-phenylmethanesulfonyl-5′-trifluormethyl-biphenyl-3-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3′-phenylmethanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(3′-Cyclopropylmethanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(3′-6-Cyclopropylmethanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(3′-ethanesulfonyl-5′-trifluoromethyl-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(propane-2-sulfonyl)-5′-trifluoromethyl-biphenyl-4-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(5′-isopropyl-3′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(5′-ethyl-3′-methanesulfonyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(3′-ethanesulfonyl-5′-isopropyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-(3′-methanesulfonyl-5′-trifluoromethyl-biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         25 . The compound of  claim 22  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of alkyl, —R 7 —C(O)R 11 , —R 7 —(O)OR 8  or —R 7 —C(O)N(R 8 ) 2 ;   R 6  is a direct bond;   each R 7  is a direct bond;   each R 8  is independently hydrogen, alkyl, aryl or aralkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, pyrrolidinyl or piperidinyl.   
     
     
         26 . The compound of  claim 25  selected from the group consisting of the following: 
       6-(3′-Acetyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(4′-Acetyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-carboxylic acid amide; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid amide; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-carboxylic acid dimethylamide; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid dimethylamide; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3′-(pyrrolidine-1-carbonyl)-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-2-oxo-6-[4′-(piperidine-1-carbonyl)-biphenyl-3-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-carboxylic acid ethylamide; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid methylamide; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid phenylamide; 
       3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-carboxylic acid benzylamide; 
       {3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-yl}-acetic acid; 
       {4′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-3-yl}-acetic acid; 
       {3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid; 
       {4′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid; 
       {3-Chloro-3′-[5-cyano-1-(2,4-difluoro-1-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid methyl ester; and 
       {3-Chloro-3′-[5-cyano-1-(2,4-difluoro-benzyl))-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-biphenyl-4-yl}-acetic acid. 
     
     
         27 . The compound of  claim 22  wherein:
 n is 1;   m is 1 or 2;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of hydrogen, halo, alkyl, alkenyl, haloalkyl or —R 7 —OR 8 ;   R 6  is a direct bond, a straight or branched alkenylene chain or a straight or branched alkynylene chain;   R 7  is a direct bond; and   R 8  is hydrogen or alkyl.   
     
     
         28 . The compound of  claim 27  selected from the group consisting of the following: 
       6-(3′,5′-Bis-trifluoromethyl-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(3′,5′-Bis-trifluoromethyl-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(3′-Chloro-4′-ethoxy-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(3′,4′-dimethoxy-biphenyl-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(3′-Chloro-4′-ethoxy-biphenyl-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3-phenylethynyl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-phenylethynyl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[3-((E)-styryl)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-((E)-styryl)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         29 . The compound of  claim 22  wherein:
 n is 1;   m is 1 or 2;   R 2  is cyano,   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of nitro, —R 7 —N(R 8 ) 2 , —R 7 —OR 8  or —R 7 —N(R 8 )C(O)OR 10 ;   R 6  is a direct bond;   each R 7  is a direct bond;   each R 8  is independently selected from hydrogen or alkyl; and   R 10  is alkyl.   
     
     
         30 . The compound of  claim 29  selected from the group consisting of the following: 
       6-(3′-Amino-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(4′-ethoxy-3′-nitro biphenyl-3-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(3′-Amino-4′-ethoxy-biphenyl-3-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       {3′-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-4-ethoxy-biphenyl-3-yl}-carbamic acid tert-butyl ester. 
     
     
         31 . The compound of  claim 2  wherein:
 n is 1 or 2;   m is 1 or 2;   R 1  is optionally substituted aralkyl;   R 2  is hydrogen or cyano;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl;   each R 4  is independently hydrogen, halo, alkyl or haloalkyl;   each R 5  is independently selected from the group consisting of —R 7 —OR 8 , —R 7 —C_—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )—R 9 —C(O)OR 10 , —R 7 —N(R 8 )C(O)R 8 , —R 7 —N(R 8 )C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 )—OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 11 , —R 7 —N(R 8 )C(O)C(O)N(R 11 ) 2 , —R 7 —N(R 8 )C(O)C(O)OR 11 , —R 7 —N(R 8 )S(O) 2 —R 8 , and —R 7 —S(O) t R 8  (where t is 0 to 2);   R 6  is a direct bond or —O—;   each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl;   each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain;   each R 10  is independently selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and   each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl.   
     
     
         32 . The compound of  claim 31  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl;   R 2  is hydrogen or cyano;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , or R 7 —S(O) t R 8  (where t is 0 to 2);   R 6  is a direct bond or —O—;   each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; and   R 9  is selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain.   
     
     
         33 . The compound of  claim 32  selected from the group consisting of the following compounds: 
       1-[(2,4-Dimethylphenyl)methyl]-6-(3′-hydroxybiphenyl-3-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-(4′-hydroxybiphenyl-3-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       6-(4′-Acetylbiphenyl-3-yl)-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       6-(3′-Acetyl-4′-hydroxybiphenyl-3-yl)[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       6-(3′-Acetylbiphenyl-3-yl)-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       6-[3′,4′-Bis(methyloxy)biphenyl-3-yl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[4′-(methylsulfonyl)biphenyl-3-yl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)-methyl]-6-[3′-(methylsulfonyl)biphenyl-3-yl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       Ethyl [(3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)oxy]acetate; 
       1-[(2,4-Dimethylphenyl)methyl]-6-(4′-hydroxybiphenyl-4-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-(3′-hydroxybiphenyl-4-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       Ethyl [(4′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-4-yl)oxy]acetate; and 
       Ethyl [(4′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)oxy]acetate. 
     
     
         34 . The compound of  claim 31  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo or haloalkyl;   R 2  is hydrogen or cyano;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of —R 7 —N(R 8 ) 2 , —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 11 ) 2  and —R 7 —C(O)N(R 8 ) 2 ;   R 6  is a direct bond or —O—;   each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl;   R 9  is selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain;   R 11  is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl.   
     
     
         35 . The compound of  claim 34  selected from the group consisting of the following compounds: 
       3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-4-carboxamide; 
       Methyl (2E)-3-(3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)prop-2-enoate; 
       3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-N,N-dimethylbiphenyl-3-carboxamide; 
       Methyl-4-amino-3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-carboxylate; 
       3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-carboxamide; 
       3′-{5-Cyano-1[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-N-ethylbiphenyl-3-carboxamide; 
       Methyl 3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-carboxylate; 
       3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-N-methylbiphenyl-3-carboxamide; 
       Ethyl (2E)-3-(3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-4-yl)prop-2-enoate; 
       3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-N-ethylbiphenyl-4-carboxamide; 
       Methyl 3-(3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)propanoate; 
       Methyl 3-(4′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)propanoate; 
       Methyl (2E)-3-(4′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)prop-2-enoate; 
       Ethyl 3-(4′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-4-yl)propanoate; and 
       Ethyl (2E)-3-(4′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-4-yl)prop-2-enoate. 
     
     
         36 . The compound of  claim 31  wherein:
 n is 1;   m is 1 or 2;   R 1  is optionally substituted aralkyl;   R 2  is hydrogen or cyano;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )—R 9 —C(CO)OR 10 , —R 7 —N(R 8 )C(O)R 8 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 10 , —R 7 —N(R 8 )C(O)C(O)N(R 11 ) 2 ; —R 7 —N(R 8 )C(O)C(O)OR 11 , and —R 7 —N(R 83 )S(O) 2 —R 8 ;   R 6  is a direct bond or —O—;   each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl;   each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain;   each R 10  is independently selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and   each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl.   
     
     
         37 . The compound of  claim 36  selected from the group consisting of the following compounds: 
       1,1-Dimethylethyl {3-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       6-{4-[(3-Aminophenyl)oxy]phenyl}-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       6-[4-(4-Amino-phenoxy)-phenyl]-1-(2,4-dimethyl-benzyl)-1H-pyridin-2-one; 
       6-(3′-Amino-biphenyl-3-yl)-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       3-Morpholin-4-ylpropyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       3-piperazin-1-ylpropyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       4-(Dimethylamino)butyl {4-[(4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl]phenyl)oxy]phenyl}carbamate; 
       2-[(2-Hydroxyethyl)oxy]ethyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       Methyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       3-(Dimethylamino)propyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       2-{[2-(Dimethylamino)ethyl]oxy}ethyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       3-Morpholin-4-ylpropyl {3-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       N-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}methanesulfonamide; 
       6-{4-[(4-Aminophenyl)oxy]phenyl}-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1,1-Dimethylethyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       2-(Dimethylamino)ethyl {4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       N-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}ethanediamide; 
       3-Piperidin-1-ylpropyl {3-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       Ethyl ({4-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}amino)(oxo)acetate; 
       3-(Diethylamino)propyl {4-[(4-{1-[(2,4-dimethylphenyl)methyl]-6-oxo-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}carbamate; 
       Methyl (3′-{5-cyano-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)carbamate; 
       3-(Dimethylamino)propyl (3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)carbamate; 
       2-(Dimethylamino)ethyl (3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)carbamate; and 
       Ethyl N-(3′-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)glycinate. 
     
     
         38 . The compound of  claim 31  wherein:
 n is 1;   m is 1 or 2;   R 1  is optionally substituted aralkyl;   R 2  is hydrogen or cyano;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of —R 7 —N(R 8 )C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 )—OR 1 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —OR 11 , and —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —N(R 11)   2 ;   R 6  is a direct bond or —O—;   each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally-substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl;   each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain;   each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl.   
     
     
         39 . The compound of  claim 38  selected from the group consisting of the following compounds: 
       1-{3-[(4-{5-Cyano-1-[(2,4-dimethylphenyl-1-methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}-3-[4-(dimethylamino)butyl]urea; 
       1-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}-3-(2-hydroxyethyl)urea; 
       1-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}urea; 
       1-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}-3-[(2,3-dihydroxypropyl)oxy]urea; 
       1-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}-3-(2,3-dihydroxypropyl)urea; 
       1-{4-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]phenyl}-3-[4-(dimethylamino)butyl]urea; 
       1-(3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)-3-ethylurea; 
       3-(3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)-1,1-dimethylurea; 
       1-(3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)-3-[3-(dimethylamino)propyl]urea; and 
       1-(3′-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}biphenyl-3-yl)-3-[2-(dimethylamino)ethyl]urea. 
     
     
         40 . The compound of  claim 1  having the following formula (III): 
       
         
           
           
               
               
           
         
         wherein: 
         Y is oxygen or sulfur; 
         n is 1 or 2; 
         m is 1 to 4; 
         R 1  is optionally substituted aralkyl; 
         R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ; 
         R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
         each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, aryl, aralkyl, aralkenyl, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 —R 7 —OR 8 , —R 7 —OC(O)OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —O—R 9 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ; 
         R 6  is —N(R 8 )—, a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 10  is independently selected from alkyl, aryl, aralkyl or cycloalkylalkyl; and 
         R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl; 
         as an isomer, a mixture of stereoisomers, a racemic mixture thereof of stereoisomers, or as a tautomer; 
         or as a pharmaceutically acceptable salt, prodrug, solvate or polymorph thereof. 
       
     
     
         41 . The compound of  claim 40  wherein:
 Y is oxygen or sulfur;   n is 1 or 2;   m is 1 to 4;   R 1  is aralkyl or heteroarylalkyl each independently optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8  or —N(R 8 ) 2 ;   R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl;   each R 4  is independently hydrogen, halo, alkyl or haloalkyl;   each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —R 8 , —R 7 —OC(O)OR 8 —R 7 —O—R 9 —C(O)OR 8 , —R 7 —O—R 9 —OR 8 , —R 7 —C(O)R 7 , —R 7 —C(O)OR 8 —R 7 —N(R 8 )C(O)OR 10 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ;   R 6  is —N(R 8 )—, a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain;   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl;   each R 9  is a straight or branched alkylene chain;   each R 10  is independently selected from alkyl, aryl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         42 . The compound of  claim 41  wherein Y is sulfur. 
     
     
         43 . The compound of  claim 42  wherein:
 n is 1;   m is 1 to 3;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —OC(O)OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —O—R 9 —OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —S(O) t R 8  (where t is 0 to 2) and R 7 —S(O) 2 N(R 8 ) 2 ;   R 6  is a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain;   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl;   each R 9  is a straight or branched alkylene chain;   each R 10  is independently selected from alkyl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         44 . The compound of  claim 43  wherein:
 n is 1;   m is 1 to 3;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is cyano;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, —R 7 —OR 8  and —R 7 —O—R 9 —OR 8 ;   R 6  is a direct bond, a straight or branched ethylene chain, a straight or branched ethenylene chain or a straight or branched ethynylene chain;   each R 7  is a direct bond;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl; and   each R 9  is a straight or branched ethylene chain.   
     
     
         45 . The compound of  claim 44  selected from the group consisting of the following: 
       1-(2,4-Difluoro benzyl)-2-oxo-6-(5-m-tolyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-m-tolyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-2-oxo-6-(5-m-tolyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-ethoxy-phenyl)-thiophen-2-yl]-1-(2,4-dichloro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-6-[5-(4-methoxy-3-methyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-2-oxo-4-trifluoromethyl-6-[5-(2,4,5-trimethyl-phenyl)-thiophen-2-yl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-6-[5-(4-methoxy-2-methyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
       6-[5-(3,5-Bis-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-dichloro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-2-oxo-6-(5-o-tolyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-dichloro-benzyl)-6-[5-(3,4-dimethoxy-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-6-[5-(3,5-dichloro-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3,5-Dichloro-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-o-tolyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3,4-dimethoxy-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-ethoxy-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methoxy-3-methyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(2-Bromo-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[5-(3-trifluoromethyl-phenyl)-thiophen-2-yl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[5-(2-fluoro-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methoxy-3,5-dimethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-hydroxy-3,5-dimethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-hydroxy, ethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3,5-Bis-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-4-ethoxy-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3,4-dimethoxy-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methoxy-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-fluoro-4-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-phenylethynyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-phenylethynyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5-((E)-styryl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-2-oxo-6-[4-((E)-styryl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-phenethyl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-hydroxymethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methoxy-3-trifluoromethyl-phenyl-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-methyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-4-trifluoromethyl-phenyl-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-4-methyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-methoxy-4-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethoxy-4-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,47-Difluoro-benzyl)-6-[5-(4-ethoxy-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-ethoxy-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethoxy-4-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{5-[3-Chloro-4-(2,2,2-trifluoro-ethoxy)-phenyl]-thiophen-2-yl}-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-fluoro-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-fluoro-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-hydroxy-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{5-[3-Chloro-4-(2-hydroxy-ethoxy)-phenyl]-thiophen-2-yl}-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethoxy-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethoxy-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-isopropoxy-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-isopropoxy-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethoxy-5-ethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethoxy-5-ethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethyl-5 isopropoxy-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethyl-5-isopropoxy-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         46 . The compound of  claim 43  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   when m is 1, R 5  is hydrogen or —R 7 —S(O) t R 3  (where t is 0 to 2); or   when m is 2, one R 5  is —R 7 —S(O) t R 8  (where t is 0 to 2) or —R 7 —S(O) 2 N(R 8 ) 2  and the other R 5  is independently selected from the group consisting of alkyl, halo, haloalkyl and —R 7 —OR 8 ;   R 6  is a direct bond;   each R 7  is independently a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl; and   R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl.   
     
     
         47 . The compound of  claim 46  selected from the group consisting of the following: 
       1-(2,4-Dichloro-benzyl)-6-[5-(4-methanesulfonyl phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-ethanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-3-dimethylaminomethyl-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-4-trifluoromethyl-1H-pyridin-2-one; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       N-{1-(2,4-Difluoro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridin-3-ylmethyl}-methanesulfonamide; 
       3-Diethylaminomethyl-1-(2,4-difluoro-benzyl)-6-[5-(4-methanesulfonyl-thiophen-2-yl]-4-trifluoromethyl-1H-pyridin-2-one; 
       N-{1-(2,4-Difluoro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridin-3-ylmethyl}-guanidine; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[5-(3-ethanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3,5-Bis-methanesulfonyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-methylsulfanyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-methylsulfanyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methyl-3-methylsulfanyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methanesulfinyl-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(5-methanesulfinyl-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-6-[4-(3-methanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-ethoxy-3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{5-[3-(propane-1-sulfinyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{5-[3-(Butane-1-sulfinyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5-(3-phenylmethanesulfinyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Cyclopropylmethanesulfinyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethanesulfinyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(propane-1-sulfinyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{4-[3-(Butane-1-sulfinyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-(3-phenylmethanesulfinyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Cyclopropylmethanesulfinyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethanesulfinyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(propane-2-sulfinyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{5-[3-(propane-1-sulfonyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{5-[3-(Butane-1-sulfonyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5-(3-phenylmethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Cyclopropylmethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(propane-1-sulfonyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{4-[3-(Butane-1-sulfonyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Cyclopropylmethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(propane-2-sulfonyl)-5-trifluoromethyl-phenyl]-thiophen-2-yl}-4-trifluoromethyl-2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[5-(3-(propyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-isopropyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methanesulfonyl-3-trifluoromethyl phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Ethanesulfonyl-phenyl)-thiophen-2-yl]-1-(2-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-benzyl)-6-[5-(3-ethanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Fluoro-benzyl-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-benzyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Ethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-1-(2-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-benzyl)-6-[5-(3-ethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-acetic acid; 
       1-(2-Chloro benzyl)-6-[5-(3-isopropyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Fluoro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoro methyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethanesulfonyl-5-isopropyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethanesulfonyl-5-isopropyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Ethanesulfonyl-phenyl)-thiophen-2-yl]-1-(4-ethyl-2-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Ethyl-2-fluoro-benzyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Ethyl-2-fluoro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Ethanesulfonyl-5-trifluoromethyl-phenyl)-thiophen-2-yl]1-(4-ethyl-2-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Ethyl-2-fluoro-benzyl)-6-[5-(3-isopropyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo 4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       4-(1,1-Difluoro-propyl)-1-(2-fluoro-benzyl)-6-[5-(4-methanesulfonyl-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       4-(1,1-Difluoro-propyl)-1-(2-fluoro-benzyl)-6-[5-(3-methanesulfonyl-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       4-(1,1-Difluoro-propyl)-6-[5-(3-ethanesulfonyl-5-isopropyl-phenyl)-thiophen-2-yl]-1-(2-fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-tert-Butyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-tert-Butyl-5-methanesulfonyl-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethanesulfonyl-5-ethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-{5-[3-ethyl-5-(propane-1-sulfonyl)-phenyl]-thiophen-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-{5-[3-ethyl-5-(propane-2-sulfonyl)-phenyl]-thiophen-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethanesulfonyl-5-ethyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-{4-[3-ethyl-5-(propane-1-sulfonyl)-phenyl]-thiophen-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-{4-[3-ethyl-5-(propane-2-sulfonyl)-phenyl]-thiophen-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-chloro-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Ethanesulfonyl-5-isopropyl-phenyl)-thiophen-2-yl]-1-(2-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-benzyl)-6-[5-(3-ethanesulfonyl-5-isopropyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Chloro-benzyl)-6-[5-(3-ethanesulfonyl-5-isopropyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-5-isopropyl-phenyl)-acetic acid; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-5-isopropyl-phenyl)-acetic acid; 
       1-(4-Chloro-benzyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-heptyl)-6-[5-(4-methanesulfonyl-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-heptyl)-6-[5-(3-ethanesulfonyl-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-heptyl)-6-[5-(3-methanesulfonyl-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-3-methyl-butyl)-6-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-3-methyl-butyl)-6-[5-(3-ethanesulfonyl-7-phenyl)-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile, 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-3-methyl-butyl)-6-[5-(4-methanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; and 
       4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-benzenesulfonamide. 
     
     
         48 . The compound of  claim 43  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is cyano;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of halo, nitro, alkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —OC(O)OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8  and R 7 —N(R 8 )C(O)OR 10 ;   R 6  is —N(H)— or a direct bond;   each R 7  is independently a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl;   each R 9  is a straight or branched alkylene chain;   R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         49 . The compound of  claim 48  selected from the group consisting of the following: 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-formyl-4-methoxy-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       Carbonic acid tert-butyl ester 4-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]thiophen-2-yl}-phenyl ester; 
       6-[5-(3-Chloro-4-cyano-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Cyano-4-ethoxy-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Cyano-4-ethoxy-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-ethoxy-3-nitro-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Amino-4-ethoxy-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (2-Chloro-4-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenoxy)-acetic acid ethyl ester; 
       (2-Chloro-4-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenoxy)-acetic acid; 
       6-[5-(4-Amino-3-chloro-phenyl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-ethoxy-phenyl)-carbamic acid tert-butyl ester; 
       (5-[5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]thiophen-3-yl]-2-ethoxy-phenyl)-carbamic acid tert-butyl ester; 
       4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-benzoic acid methyl ester; 
       3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-benzoic acid methyl ester; 
       3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-benzoic acid; 
       4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-benzoic acid; 
       3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-5-isopropyl-benzoic acid methyl ester; 
       3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-5-isopropyl-benzoic acid methyl ester; 
       3-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-N,N-dimethyl-thiobenzamide; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-acetic acid, 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-acetic acid; 
       (4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-acetic acid; 
       (4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-acetic acid; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-acetic acid methyl ester; 
       (4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-acetic acid methyl ester; 
       (4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-4-thiophen-3-yl}-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-5-isopropoxy-phenyl)-acetic acid; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-methoxy-phenyl)-acetic acid methyl ester; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-2-methoxy-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-5-isopropoxy-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-4-fluoro-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-4-methoxy-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-5-isopropoxy-phenyl)-acetic acid; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-methoxy-phenyl)-acetic acid; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-2-methoxy-phenyl)-acetic acid; 
       2-(3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-2-methyl-propionic acid methyl ester; 
       2-(3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-2-methyl-propionic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-4-fluoro-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-4-methoxy-phenyl)-acetic acid; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-4-(1,1-difluoro-heptyl)-6-oxo-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-acetic acid methyl ester; 
       (2-Chloro-4-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-acetic acid methyl ester; 
       (2-Chloro-4-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-acetic acid tert-butyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-4-(1,1-difluoro-3-methyl-butyl)-6-oxo-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}phenyl)-acetic acid methyl ester; 
       3-(3-{5-[5-Cyano-4-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-phenyl)-propionic acid methyl ester; 
       3-(3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-phenyl)-propionic acid methyl ester; 
       3-(4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro pyridin-2-yl]-thiophen-2-yl}-phenyl)-propionic acid methyl ester; and 
       3-(4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro pyridin-2-yl]-thiophen-3-yl}-phenyl)-propionic acid methyl ester. 
     
     
         50 . The compound of  claim 41  wherein Y is oxygen. 
     
     
         51 . The compound of  claim 50  wherein:
 n is 1;   m is 1 to 3;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  cyano;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of halo, nitro, alkyl, haloalkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —OC(O)OR 8 , —R 8 —R—C(O)OR 8 , —R 7 —O—R 9 —OR 8 , —R 7 —C(O)R 10 , —R 7 —C(O)OR 8 , —R 7 —N(R 8 )C(O)OR 10  and —R 7 —S(O) t R 8  (where t is 0 to 2);   R 6  is a direct bond;   each R 7  is independently selected from a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl;   each R 9  is a straight or branched alkylene chain;   R 10  is alkyl, alkyl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         52 . The compound of  claim 51  wherein:
 n is 1;   m is 1 to 3;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is cyano;   R 3  is methyl or trifluoromethyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of halo, alkyl, haloalkyl, —R 7 —OR 8  and —R 7 —O—R 9 —OR 8 ;   R 6  is a direct bond;   each R 7  is independently a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl; and   each R 9  is a straight or branched ethylene chain.   
     
     
         53 . The compound of  claim 52  selected from the group consisting of the following: 
       6-[5-(3,5-Bis-trifluoromethyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(2-Chloro-5-trifluoromethyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3,4-dimethoxy-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-hydroxy-3-methoxy-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3,5-Bis-trifluoromethyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-4-ethoxy-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methoxy-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-fluoro-4-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-fluoro-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methoxy-3-trifluoro-ethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-4-methyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-4-trifluoromethyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-trifluoromethyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-fluoro-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[4-(4-fluoro-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(3-Chloro-4-methyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4 (4-ethoxy-3-trifluoromethyl phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-6-[4-(3-ethoxy-4-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethoxy-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-isopropoxy-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethoxy-5-ethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethyl-5-isopropoxy-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         54 . The compound of  claim 51  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 11  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   when m is 1, R 5  is hydrogen or —R 7 —S(O)R 8  (where t is 0 to 2); or   when m is 2, one R 5  is —R 7 —S(O) t R 8  (where t is 0 to 2) and the other R 5  is independently selected from the group consisting of halo, haloalkyl and —R 7 —OR 8 ;   is a direct bond;   each R 7  is a direct bond;   each R 8  is independently selected from hydrogen, alkyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl; and   R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl.   
     
     
         55 . The compound of  claim 54  selected from the group consisting of the following: 
       1-(2,4-Difluoro-2-benzyl)-6-[5-(4-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methylsulfanyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-methylsulfanyl-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-methylsulfanyl-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methyl-3-methylsulfanyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-6-[4-(4-methanesulfonyl-3-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-6-[4-(3-methanesulfonyl-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-methanesulfonyl-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-[5-(3-methanesulfonyl-5-trifluoromethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{5-[3-(propane-2-sulfonyl-5-trifluoromethyl-phenyl]-furan-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethanesulfonyl-5-trifluoro-ethyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(propane-1-sulfonyl)-5-trifluoromethyl-phenyl]-furan-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{4-[3-(propane-2-sulfonyl)-5-trifluoromethyl-phenyl]-furan-2-yl}-4-trifluoroethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-{5-[3-(propane-1-sulfonyl)-5-isopropyl-phenyl]-furan-2-yl}-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-isopropyl-5-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethyl-5-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(3-ethyl-5-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(3-ethanesulfonyl-5-isopropyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Fluoro-benzyl)-6-[4-(4-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-4-(1,1-difluoro-propyl)-6-[4-(3-ethanesulfonyl-5-isopropyl-phenyl)-furan-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-tert-Butyl-5-methanesulfonyl-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Fluoro-benzyl)-6-[4-(3-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Ethanesulfonyl-phenyl)-furan-2-yl]-1-(2-fluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluorobenzyl)-6-{4-[3-ethyl-5-(propane-1-sulfonyl)-phenyl]-furan-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-{4-[3-ethyl-5-(propane-2-sulfonyl)-phenyl]-furan-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl-6-[5-(3-methanesulfonyl-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         56 . The compound of  claim 51  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 2  is cyano;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   R 4  is hydrogen;   each R 5  is independently selected from the group consisting of halo, nitro, alkyl, —R 7 —CN, —R 7 —N(R 8 ) 2 , —R 7 —OR 8 , —R 7 —OC(O)OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8  and —R 7 —N(R 8 )C(O)OR 10 ;   R 6  is a direct bond;   each R 7  is independently a direct bond or a straight or branched alkylene chain;   each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl or cycloalkylalkyl;   each R 9  is a straight or branched alkylene chain;   R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl; and   R 11  is hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heterarylalkyl.   
     
     
         57 . The compound of  claim 56  selected from the group consisting of the following: 
       6-[4-(3-Chloro-4-cyano-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Cyano-4-ethoxy-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(4-ethoxy-3-nitro-phenyl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(4-Amino-3-chloro-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-1,6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-2-ethoxy-phenyl)-carbamic acid tert-butyl ester; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-2-yl}-2-ethoxy-phenyl)-carbamic acid tert-butyl ester; 
       3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-5-isopropyl-benzoic acid methyl ester; 
       6-[4-(3-Amino-4-ethoxy-phenyl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-acetic acid; 
       (4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-acetic acid; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-5-isopropyl-phenyl)-acetic acid; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-acetic acid methyl ester; 
       (4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-acetic acid methyl ester; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-2-methoxy-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-5-isopropoxy-phenyl)-acetic acid; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-4-methoxy-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-4-fluoro-phenyl)-acetic acid methyl ester; 
       2-(3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-2-methyl-propionic acid methyl ester; 
       (5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-2-methoxy-phenyl)-acetic acid; 
       (2-Chloro-4-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl, 1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-acetic acid methyl ester; 
       (3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-benzyl)-carbamic acid tert-butyl ester; 
       3-(3-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-propionic acid methyl ester; and 
       3-(4-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-phenyl)-propionic acid methyl ester. 
     
     
         58 . The compound of  claim 1  having the following formula (IV): 
       
         
           
           
               
               
           
         
         wherein: 
         n is 1 to 4; 
         m is 1 to 4; 
         R 1  is optionally substituted aralkyl or optionally substituted heteroarylalkyl; 
         R 2  is hydrogen, cyano, —C(O)OR 8 , —C(O)N(R 8 ) 2  or —R 7 —N(R 8 ) 2 ; 
         R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl; 
       
       
         
           
           
               
               
           
         
         is heterocyclyl or heteroaryl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
         each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, haloalkyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, —R 17 —CN, —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 )OR 11 , —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(O)N(R 8 )—R 9 —OR 11 , —R 7 —C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )—R 9 —C(O)OR 10 , —R 7 —N(R 8 )C(O)R 8 , —R 7 —N(R 8 )C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 )—OR 1 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —OR 8 , —R 7 —N(R 8 )C(O)N(R 11 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —N(R 8 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 7 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 11 , —R 7 —N(R 8 )C(O)C(O)N(R 11 ) 2 , —R 7 —N(R 8 )C(O)C(O)OR 11 , —R 7 —N(R 8 )S(O) 2 —R 8 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ; 
         R 6  is —OR 7 —, —N(R 8 )—, a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         each R 10  is independently selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl. 
       
     
     
         59 . The compound of  claim 58  wherein:
 R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting, of chloro, bromo, fluoro, methyl or ethyl;   
       
         
           
           
               
               
           
         
         is a N-heteroaryl selected from the group consisting of indolyl and thiazolyl; 
         each R 5  is independently selected from the group consisting of halo, alkyl, haloalkyl, —R 7 —CN and —R 7 —C(O)OR 8 ; and 
         R 6  is a direct bond. 
       
     
     
         60 . The compound of  claim 59  selected from the group consisting of the following: 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3-thiazol-2-yl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       5-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-1H-indole-2-carboxylic acid ethyl ester. 
     
     
         61 . The compound of  claim 58  wherein:
 R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   
       
         
           
           
               
               
           
         
         is a N-heteroaryl selected from the group consisting of indolyl, pyrimidyl, pyrazinyl, pyridinyl and thiazolyl; 
         each R 5  is independently selected from the group consisting of halo, alkyl, haloalkyl, —R 7 —CN and —R 7 —C(O)OR 8 ; and 
         R 6  is —O—. 
       
     
     
         62 . The compound of  claim 61  selected from the group selected from the following: 
       1-(2,4-Dimethyl-benzyl)-6-[4-(1H-indol-5-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-2-oxo-6-[4-(pyrimidin-2-yloxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethylbenzyl)-2-oxo-6-[4-(pyrazin-2-yloxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(4,6-dimethyl-pyrimidin-2-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-2-oxo-6-[4-(pyrazin-2-yloxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-(pyrazin-2-yloxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3,6-dimethyl-pyrazin-2-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-pyrazin-2-yloxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(6-Chloro-pyrazin-2-yloxy)-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       2-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-nicotinonitrile; 
       2-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-6-methyl-nicotinonitrile; 
       1-(2,4-Dimethyl-benzyl)-2-oxo-4-trifluoromethyl-6-[4-(5-trifluoro-ethyl-pyridin-2-yloxy)-phenyl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-6-[4-(1H-indol-5-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(1H-indol-5-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-4-fluoro-benzyl)-6-[4-(1H-indol-5-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[(3-methyl-4-(pyrazin-2-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-pyrazin-2-yloxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(6-Chloro-pyrazin-2-yloxy)-3-methyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3,6-dimethyl-pyrazin-2-yloxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[3-isopropyl-4-(pyrazin-2-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(3-Chloro-pyrazin-2-yloxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(6-Chloro-pyrazin-2-yloxy)-3-isopropyl-phenyl]-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(3,6-dimethyl-pyrazin-2-yloxy)-3-isopropyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       2-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-2-isopropyl-phenoxy}-6-methyl-nicotinonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-(pyrimidin-2-yloxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       3-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-pyrazine-2-carbonitrile; 
       2-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-6-methyl-nicotinonitrile; 
       2-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-nicotinonitrile; 
       6-[4-(6-Chloro-pyrazin-2-yloxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[3-Chloro-4-(pyrimidin-2-yloxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[3-Chloro-4-(pyrazin-2-yloxy)-phenyl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       2-{2-Chloro-4-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-nicotinonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(1H-indol-5-yloxy)-3,5-dimethyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(1H-indol-5-yl)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[3-(1H-indol-5-yl)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3-pyridin-3-yl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3-pyridin-4-yl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dimethyl-benzyl)-6-[4-(1H-indol-5-yloxy)-3-methyl-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[4-(3-trifluoromethyl-pyridin-2-yloxy)-phenyl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[4-(6-trifluoromethyl-pyridin-2-yloxy)-phenyl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(1H-indol-6-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-4-trifluoromethyl-nicotinic acid methyl ester; 
       1-(2,4-Dichloro-benzyl)-6-[4-(1-methyl-1H-indol-5-yloxy)-phenyl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       5-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-1H-indole-2-carboxylic acid ethyl ester. 
     
     
         63 . The compound of  claim 58  wherein:
 R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   
       
         
           
           
               
               
           
         
         is N-heterocyclyl selected from the group consisting of piperidinyl and piperazinyl; and 
         each R 5  is independently selected from the group consisting of halo, alkyl, haloalkyl, —R 7 —CN and —R 7 —C(O)OR 8 . 
       
     
     
         64 . The compound of  claim 63  selected from the group consisting of the following: 
       1-(2,4-Dimethyl benzyl)-2-oxo-6-[4-(piperidin-4-yloxy)-phenyl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(3-piperidin-1-yl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;
 4-{3-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester; 
 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-piperidin-1-yl-phenyl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       4-{4-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester; and 
       4-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester. 
     
     
         65 . The compound of  claim 58  wherein:
 R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   
       
         
           
           
               
               
           
         
         is benzodioxolyl; 
         each R 5  is independently selected from the group consisting of halo, alkyl, haloalkyl, —R 7 —CN and —R 7 —C(O)OR 8 ; and 
         R 6  is a direct bond. 
       
     
     
         66 . The compound of  claim 65  selected from the group consisting of the following: 
       6-(3-Benzo[1,3]dioxol-5-yl-phenyl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       6-(4-Benzo[1,3]dioxol-5-yl-phenyl)-1-(2,4-dimethyl-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         67 . The compound of  claim 58  wherein:
 n is 1 to 4;   m is 1 to 4;   R 1  is optionally substituted aralkyl or optionally substituted heteroarylalkyl;   R 2  is hydrogen, cyano, —C(O)OR 8 , —C(O)N(R 8 ) 2  or —R 7 —N(R 8 ) 2 ;   R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl,   
       
         
           
           
               
               
           
         
         is heterocyclyl or heteroaryl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, optionally substituted aralkyl, —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 11 ) 2 , —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —OR 11 , —R 7 —C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —OR 9 —N(R 11 ) 2 , and —R 7 —N(R 8 )C(O)OR 9 —OR 11 ; 
         R 6  is —OR 7 —, —N(R 8 )— or a direct bond; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         R 10  is selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl. 
       
     
     
         68 . The compound of  claim 67  wherein:
 n is 1;   m is 1 or 2;   R 1  is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8 , —N(R 8 ) 2 , or —N(R 8 )C(O)OR 10 ;   or R 1  is pyridinylalkyl optionally substituted with one or more substituents independently selected from, alkyl, halo, haloalkyl, —OR 8 , —N(R 8 ) 2  or —N(R 8 )C(O)OR 10 ;   R 2  is hydrogen, —C(O)OR 8 , —C(O)N(R 8 ) 2  or cyano;   R 3  is hydrogen, methyl, difluoromethyl or trifluoromethyl;   
       
         
           
           
               
               
           
         
         is indolyl, benzimidazolyl, pyrazolyl, or benzodioxinyl; 
         R 4  is hydrogen; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, optionally substituted aralkyl, —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 11 ) 2 —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —OR 11 , —R 7 —C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —OR 9 —N(R 11 ) 2 , and —R 7 —N(R 8 )C(O)OR 9 —OR 11 ; 
         R 6  is —O—, —N(H)— or a direct bond; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         R 10  is selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl. 
       
     
     
         69 . The compound of  claim 68  wherein:
 R 1  is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8 , —N(R 8 ) 2  or —N(R 8 )C(O)OR 10 ;   
       
         
           
           
               
               
           
         
         is indolyl, benzimidazolyl, pyrazolyl or benzodioxinyl; and 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, and optionally substituted aralkyl. 
       
     
     
         70 . The compound of  claim 69  selected from the group consisting of the following compounds: 
       6-[4-(1H-Benzimidazol-5-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[3-(1H-indol-6-yl)phenyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[3-(1H-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[3-(1-methyl-1H-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       6-[3-(1H-Benzimidazol-5-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-2-oxo-6-[3-(1H-pyrazol-4-yl)phenyl]-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-2-oxo-6-{3-[1-(phenylmethyl)-1H-pyrazol-4-yl]phenyl}-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-{3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]phenyl}-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[4-(1H-indol-6-yl)phenyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[4-(1H-indol-5-yl)phenyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; and 
       6-[3-(2,3-Dihydro-1,4-benzodioxin-6-yl)phenyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile. 
     
     
         71 . The compound of  claim 68  wherein:
 R 1  is benzyl optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8 , —N(R 8 ) 2 , or —N(R 8 )C(O)OR 10 ;   or R 1  is pyridinylalkyl optionally substituted with one or more substituents independently selected from alkyl, halo, haloalkyl, —OR 8 , —N(R 8 ) 2  or —N(R 8 )C(O)OR 10 ;   
       
         
           
           
               
               
           
         
         is indolyl, benzimidazolyl or pyrazolyl; 
         each R 5  is independently selected from the group consisting of hydrogen, —R 7 —C(O)OR 8 , —R 7 —C(O)OR 9 —N(R 8 ) 2 , —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —OR 11 , and —R 7 —C(O)N(R 8 )—R 9 —N(R 11 ) 2 ; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         R 10  is selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl. 
       
     
     
         72 . The compound of  claim 71  selected from the group consisting of the following compounds: 
       Ethyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(difluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-carbamoyl-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-carboxy-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-cyano-1-[(2-amino-6-methylpyridin-5-yl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       5-{4-[1-(2,4-Dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenoxy}-1H-indole-2-carboxylic acid; 
       3-Morpholin-4-ylpropyl-5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       3-Piperazin-1-ylpropyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-{(4-[5-cyano-1-[(2,4-dimethylphenyl)methyl]-4-methyl-6-oxy-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       4-(Dimethylamino)butyl 5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       3-(Dimethylamino)propyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       2-{[2-(dimethylamino)ethyl]oxy}ethyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxy-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 6-[(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 6-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       1-Methylethyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-phenyl)oxy]-1H-indole-2-carboxylate; 
       3-(Dimethylamino)-2,2-dimethylpropyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       1-Methylpiperidin-4-yl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       3-(Diethylamino)-2,2-dimethylpropyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-cyano-1-[(2,4-dichlorophenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       3-(Dimethylamino)propyl 5-[(4-{1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl oxy]-1H-indole-2-carboxylate; 
       2-(dimethylamino)ethyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-propyl-1H-indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N,N-dimethyl-1H-indole-2-carboxamide; 
       Ethyl 5-({4-[5-cyano-1-{[2-methyl-4-(methyloxy)phenyl]methyl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl]phenyl}oxy)-1H-indole-2-carboxylate; 
       2,3-Dihydroxypropyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-cyano-[(2,6-dimethylpyridin-3-yl methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       Ethyl 5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)amino]-1H-indole-2-carboxylate; 
       5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-(1-methylethyl)-1H-indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-(2-methylpropyl)-1H-indole-2-carboxamide; 
       Ethyl 5-[(4-{1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-[3-(diethylamino)propyl]-1H-indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-ethyl-1H-indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-(2-hydroxyethyl)-1H indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-(2,3-dihydroxypropyl)-1H-indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-N-[(2,3-dihydroxypropyl)oxy]-1H-indole-2-carboxamide; 
       5-[(4-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylic acid; 
       5-[(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)amino]-1H-indole-2-carboxylic acid; 
       3-Piperidin-1-ylpropyl 6-(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylate; 
       Ethyl 6-(3-{5-cyano-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylate; 
       3-(Dimethylamino)propyl 6-(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylate; 
       Ethyl 5-(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylate; 
       1,1-Dimethylethyl 4-(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-pyrazole-1-carboxylate; 
       Ethyl 5-[(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)oxy]-1H-indole-2-carboxylate; 
       6-(3-{5-Cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylic acid; 
       1,1-Dimethylethyl 5-(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-1-carboxylate; 
       Ethyl [4-(3-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-pyrazol-1-yl]acetate; 
       Ethyl 6-(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylate; 
       Ethyl 5-(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-2-carboxylate; 
       5-{4-[5-Cyano-1-(2,4-dimethyl-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-phenyl}-1H-indole-2-carboxylic acid; 
       1-Dimethylethyl 6-(3-{5-cyano-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1-indole-1-carboxylate; and 
       1,1-Dimethylethyl 6-(4-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}phenyl)-1H-indole-1-carboxylate. 
     
     
         73 . The compound of  claim 1  having the following formula (V): 
       
         
           
           
               
               
           
         
         wherein: 
         n is 1 or 2; 
         m is 1 to 4; 
         Y is oxygen or sulfur, 
         R 1  is optionally substituted aralkyl; 
         R 2  is cyano or —R 7 —N(R 8 ) 2 ; 
         R 3  is alkyl, hydroxyalkyl or haloalkyl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
       
       
         
           
           
               
               
           
         
         is naphthyl, heterocyclyl or heteroaryl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, haloalkyl, heterocyclyl, —R 7 —OR 8 , —R 7 —CN, —R 7 —C(O)OR 8 , —R 7 —OC(O)R 10  and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         R 6  is a direct bond; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; 
         R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl; 
         as an isomer, a mixture of stereoisomers, a racemic mixture thereof of stereoisomers, or as a tautomer; 
         or as a pharmaceutically acceptable salt, prodrug, solvate or polymorph thereof. 
       
     
     
         74 . The compound of  claim 73  wherein:
 Y is —O—;   R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   
       
         
           
           
               
               
           
         
         is a N-heteroraryl selected from the group consisting of pyrimidinyl and pyridinyl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, haloalkyl, morpholinyl, piperazinyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —C(O)OR 8 , —R 7 —OC(O)R 10  and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         each R 7  is independently a direct bond or a methylene chain; 
         each R 8  is hydrogen or alkyl; and 
         R 10  is alkyl or cycloalkylalkyl. 
       
     
     
         75 . The compound of  claim 74  selected from the group consisting of the following: 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-methoxy-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(2,4-dimethoxy-pyrimidin-5-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-pyridin-4-yl-furan-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-5-trifluoromethyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoro ethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-methylsulfanyl pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-methanesulfonyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-2-ethoxy-nicotinonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-isopropoxy-5-trifluoromethyl pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-methanesulfonyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-2-ethoxy-nicotinic acid ethyl ester; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-2-yl}-2-ethoxy-nicotinic acid ethyl ester; 
       1-(2,4-Difluoro-benzyl)-6-[4-(5-methyl-6-methylsulfanyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-furan-3-yl}-2-methanesulfonyl-nicotinic acid methyl ester; 
       1-(2,4-Difluoro-benzyl)-6-[4-(5-isopropenyl-6-methylsulfanyl pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-5-isopropenyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(5 isopropenyl-6-methanesulfonyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzil)-4-(1,1-difluoro-propyl)-6-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-furan-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[4-(6-ethylsulfanyl-5-methyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-5-isopropyl-pyridin-3-yl]-furan-2-yl 2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(5-isopropyl-methanesulfonyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethanesulfonyl-5-methyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[4-(2-Chloro-pyridin-4-yl)-furan-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Fluoro-benzyl)-6-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-(6-piperazin-1-yl-pyridin-3-yl)-furan-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         76 . The compound of  claim 73  wherein:
 Y is —O—;   R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   
       
         
           
           
               
               
           
         
         is heterocyclyl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, haloalkyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —C(O)OR 8 , —R 7 —OC(O)R 10  and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         each R 7  is independently a direct bond or a methylene chain; 
         each R 8  is hydrogen or alkyl; and 
         R 10  is alkyl or cycloalkylalkyl. 
       
     
     
         77 . The compound of  claim 76  selected from the group consisting of the following: 
       6-(5-Benzo[1,3]dioxol-5-yl-furan-2-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-[5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-furan-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         78 . The compound of  claim 73  wherein:
 Y is —S—;   R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   
       
         
           
           
               
               
           
         
         is a N-heteroaryl selected from the group consisting of pyridinyl, indolyl and pyrimidinyl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, haloalkyl, morpholinyl, piperazinyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —C(O)OR 8 , —R 7 —OC(O)R 10  and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         each R 7  is independently a direct bond or a methylene chain; 
         each R 8  is hydrogen or alkyl; and 
         R 10  is alkyl or cycloalkylalkyl. 
       
     
     
         79 . The compound of  claim 78  selected from the group consisting of the following: 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-pyridin-3-yl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-pyridin-4-yl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-pyridin-3-yl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(4-pyridin-4-yl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(1H-indol-5-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-2-oxo-6-(5-pyridin-2-yl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-methoxy-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(2,4-dimethoxy-pyrimidin-5-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(5-pyrimidin-5-yl-thiophen-2-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(2,6-Bis-trifluoromethyl-pyridin-4-yl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-ethoxy-5-trifluoromethyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-5-trifluoromethyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-methylsulfanyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-methanesulfonyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-methylsulfanyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-6-[4-(6-methanesulfonyl-pyridin-3-yl-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-ethoxy-nicotinonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-2-ethoxy-nicotinonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-ethoxy-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-isopropoxy-5-trifluoromethyl-pyridin-3-yl-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5-(1-oxy-pyridin-4-yl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-ethoxy-nicotinic acid ethyl ester; 
       1-(2,4-Difluoro benzyl)-6-[4-(5-methyl-6-methylsulfanyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(5-methyl-6-methylsulfanyl-pyridin-3-yl-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-methylsulfanyl-nicotinic acid methyl ester; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-2-methylsulfanyl-nicotinic acid methyl ester; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-methanesulfonyl-nicotinic acid methyl ester; 
       5-{5-[5-Cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-3-yl}-2-methanesulfonyl-nicotinic acid methyl ester; 
       1-(2,4-Difluoro-benzyl)-6-[5-(5-isopropenyl-6-methylsulfanyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(5-isopropenyl-6-methanesulfonyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Fluoro-benzyl)-6-[5-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[5-(6-ethoxy-5-isopropenyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Ethyl-2-fluoro-benzyl)-6-[5-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2-Chloro-benzyl)-6-[5-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-5-isopropenyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-ethoxy-5-isopropyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-ethylsulfanyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethoxy-5-isopropyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(5-isopropyl-6-methanesulfonyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-ethanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl-6-[4-(6-ethanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-ethoxy-2-methanesulfonyl-pyrimidin-4-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       4-(1,1-Difluoro-propyl)-1-(2-fluoro-benzyl)-6-[5-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-ethylsulfanyl-5-methylpyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(2-methanesulfonyl-6-trifluoromethylpyridin-4-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       Acetic acid 1-(5-{5-[5-cyano-1-(2,4-difluoro-benzyl)-6-oxo-4-trifluoromethyl-1,6-dihydro-pyridin-2-yl]-thiophen-2-yl}-2-methanesulfonyl-pyridin-3-yl)-ethyl ester; 
       1-(2,4-Difluoro-benzyl)-6-[5-(2-ethanesulfonyl-6-ethyl-pyridin-4-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Chloro-benzyl)-6-[5-(6-methanesulfonyl-5-methyl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-{5-[5-(1-hydroxy-ethyl)-6-methanesulfonyl-pyridin-3-yl]-thiophen-2-yl}-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(6-morpholin-4-yl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluormethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[5-(2 Chloro-pyridin-4-yl)-thiophen-2-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(4-Chloro-benzyl)-6-[5-(3-ethanesulfonyl-phenyl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[5-(6-piperazin-1-yl-pyridin-3-yl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-[4-(6-piperazin-1-yl-pyridin-3-yl)-thiophen-2-yl]-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-[4-(6-morpholin-4-yl-pyridin-3-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         80 . The compound of  claim 73  wherein:
 Y is —S—;   R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   
       
         
           
           
               
               
           
         
         is heterocyclyl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, haloalkyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —C(O)OR 8 , —R 7 —OC(O)R 10  and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         each R 7  is independently a direct bond or a methylene chain; 
         each R 8  is hydrogen or alkyl; and 
         R 1  is alkyl or cycloalkylalkyl. 
       
     
     
         81 . The compound of  claim 80  selected from the group consisting of the following: 
       6-(4-Benzo[1,3]dioxol-5-yl-thiophen-2-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-(5-Benzo[1,3]dioxol-5-yl-thiophen-2-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro benzyl)-6-[5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[5-(2,3-dihydro-benzofuran-5-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-[4-(2,3-dihydro-benzofuran-5-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         82 . The compound of  claim 73  wherein:
 Y is —S—;   R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl;   R 3  is alkyl, hydroxyalkyl or haloalkyl;   
       
         
           
           
               
               
           
         
         is naphthyl; and 
         each R 5  is independently selected from hydrogen, alkyl, halo or haloalkyl. 
       
     
     
         83 . The compound of  claim 82  selected from the group consisting of the following: 
       1-(2,4-Dichloro-benzyl)-6-[5-(4-methyl-naphthalen-1-yl)-thiophen-2-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(5-naphthalen-2-yl-thiophen-2-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-6-(5-naphthalen-1-yl-thiophen-2-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         84 . The compound of  claim 1  having the following formula (VI): 
       
         
           
           
               
               
           
         
         wherein: 
         n is 1 or 2; 
         m is 1 to 4; 
         R 1  is optionally substituted aralkyl; 
         R 2  is cyano or —R 7 —N(R 8 ) 2 ; 
         R 3  is alkyl, hydroxyalkyl or haloalkyl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
       
       
         
           
           
               
               
           
         
         is aryl or heteroaryl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, haloalkyl, —R 7 —OR 8 , —R 7 —CN, —R 7 —C(O)OR 8 , —R 7 —OC(O)R 10  and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         R 6  is a direct bond or a straight or branched alkylene chain; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, aralkyl, aralkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; and 
         R 10  is alkyl, aryl, aralkyl or cycloalkylalkyl; 
         as an isomer, a mixture of stereoisomers, a racemic mixture thereof of stereoisomers, or as a tautomer; 
         or as a pharmaceutically acceptable salt, prodrug, solvate or polymorph thereof. 
       
     
     
         85 . The compound of  claim 84  wherein:
 R 1  is benzyl optionally substituted by one or more substituents selected from the group consisting of chloro, bromo, fluoro, methyl or ethyl; and   
       
         
           
           
               
               
           
         
         is phenyl or pyridinyl; 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, halo, haloalkyl, —R 7 —OR 8 , —R 7 —CN and —R 7 —S(O) t R 8  (where t is 0 to 2); 
         each R 7  is a direct bond or a straight or branched alkylene chain; 
         each R 8  is hydrogen or alkyl; and 
         R 10  is alkyl. 
       
     
     
         86 . The compound of  claim 85  wherein 
       
         
           
           
               
               
           
         
         is phenyl; and 
         each R 5  is independently selected from the group consisting of alkyl, halo, haloalkyl, —R 7 —OR 8 , —R 7 —CN and —R 7 —S(O) t R 8  (where t is 0 to 2). 
       
     
     
         87 . The compound of  claim 86  selected from the group consisting of the following: 
       6-(1-Benzyl-1H-pyrazol-4-yl)-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(1-phenyl-1H-pyrazol-4-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-6-(1-phenyl-5-trifluoromethyl-1H-pyrazol-4-yl)-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Dichloro-benzyl)-6-[1-benzyl-1H-pyrazol-4-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[1-(4-methoxy-benzyl)-1H-pyrazol-4-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[1-(3-Cyano-4-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[1-(3-Chloro-4-cyano-phenyl)-1H-pyrazol-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       6-[1-(3-Chloro-4-ethoxy-phenyl)-1H-pyrazol-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[1-(4-methanesulfonyl-phenyl)-1H-pyrazol-4-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-6-[1-(3,4-dimethoxy-phenyl)-1H-pyrazol-4-yl]-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile; and 
       6-[1-(4-Cyano-3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-1-(2,4-difluoro-benzyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         88 . The compound of  claim 85  wherein
 m is 1 or 2;   
       
         
           
           
               
               
           
         
         is pyridinyl; and 
         each R 5  is independently selected from the group consisting of hydrogen, alkyl, halo, haloalkyl, —R 7 —OR 8 , —R 7 —CN and —R 7 —S(O) t R 8  (where t is 0 to 2). 
       
     
     
         89 . The compound of  claim 88  selected from the group consisting of the following: 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[1-(3-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-1,2-dihydro-pyridine-3-carbonitrile; 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[1-(6-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-1,2-dihydro-pyridine-3-carbonitrile; and 
       1-(2,4-Difluoro-benzyl)-2-oxo-4-trifluoromethyl-6-[1-(5-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-1,2-dihydro-pyridine-3-carbonitrile. 
     
     
         90 . The compound of  claim 1  wherein:
 n is 1 or 2;   m is 1 or 2;   
       
         
           
           
               
               
           
         
         is thienyl or pyridinyl; 
       
       
         
           
           
               
               
           
         
         indolyl or benzimidazolyl; 
         R 1  is hydrogen, optionally substituted aralkyl or optionally substituted heteroarylalkyl; 
         R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 8 ) 2 ; 
         R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
         each R 5  is independently selected from the group consisting of hydrogen, halo, nitro, alkyl, alkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, haloalkyl, haloalkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, —R 7 —CN, —R 7 —OR 8 , —R 7 —O—R 9 —C(O)OR 8 , —R 7 —C(O)R 11 , —R 7 —C(O)OR 8 —R 7 —C(O)OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 )OR 11 , —R 7 —C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —C(O)N(R 8 ) 2 , —R 7 —C(O)N(R 8 )OR 8 , —R 7 —C(O)N(R 8 )N(R 8 ) 2 , —R 7 —C(O)N(R 8 )—R 9 —C(O)OR 8 , —R 7 —C(O)N(R 8 )—R 9 —OR 1 , —R 7 , —C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —C(S)N(R 8 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )—R 9 —C(Q)R 10 , —R 7 —N(R 8 )C(O)R 8 , —R 7 —N(R 8 )C(O)N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 )—OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —OR 11 , —R 7 —N(R 8 )C(O)N(R 8 )—R 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )C(O)OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 9 —N(R 11 ) 2 , —R 7 —N(R 8 )C(O)OR 9 —OR 11 , —R 7 —N(R 8 )C(O)C(O)N(R 11 ) 2 , —R 7 —N(R 8 )C(O)C(O)OR 11 , —R 7 —N(R 8 )S(O) 2 —R 8 , —R 7 —S(O) t R 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 8 ) 2 ; 
         R 6  is a direct bond; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; 
         each R 9  is independently selected from a straight or branched optionally substituted alkylene chain or a straight or branched optionally substituted alkenylene chain; 
         each R 10  is independently selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl; and 
         each R 11  is independently hydrogen, alkyl optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heterarylalkyl. 
       
     
     
         91 . The compound of  claim 90  wherein:
 n is 1 or 2;   m is 1 or 2;   
       
         
           
           
               
               
           
         
         is thienyl or pyridinyl; 
       
       
         
           
           
               
               
           
         
         is indolyl or benzimidazolyl; 
         R 1  is hydrogen, optionally substituted aralkyl or optionally substituted heteroarylalkyl; 
         R 2  is hydrogen, cyano, —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )S(O) 2 R 10  or —R 7 —N(R 8 )C(NR 8 )N(R 6 ) 2 ; 
         R 3  is hydrogen, alkyl, hydroxyalkyl or haloalkyl; 
         each R 4  is independently hydrogen, halo, alkyl or haloalkyl; 
         each R 5  is independently selected from the group consisting of hydrogen, —R 7 —C(O)OR 8 —R 7 —C(O)N(R 5 ) 2 , —R 7 —N(R 8 ) 2 , —R 7 —N(R 8 )C(O)N(R 8 ) 2 , R 7 —N(R 8 )C(O)OR 10 , —R 7 —N(R 8 )S(O) 2 —R 8 , —R 7 —S(OR 8  (where t is 0 to 2) and —R 7 —S(O) 2 N(R 3 ) 2 ; 
         R 6  is a direct bond; 
         each R 7  is independently selected from a direct bond, a straight or branched alkylene chain or a straight or branched alkenylene chain; 
         each R 8  is independently selected from hydrogen, alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, haloalkyl, haloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or heteroarylalkyl; and 
         R 10  is selected from alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted cycloalkylalkyl. 
       
     
     
         92 . The compound of  claim 91  selected from the group consisting of the following compounds: 
       Ethyl 6-{5′-cyano-1′-[(2,4-dimethylphenyl)methyl]-6′-oxo-4′-(trifluoromethyl)-1′,6′-dihydro-2,2′-bipyridin-6-yl}-1H-indole-2-carboxylate; 
       6-{5′-Cyano-1′-[(2,4-dimethylphenyl)methyl]-6′-oxo-4′-(trifluoromethyl)-1′,6′-dihydro-2,2′-bipyridin-6-yl}-1H-indole-2-carboxylic acid; 
       3-(Dimethylamino)propyl 6-{5′-cyano-1′-[(2,4-dimethylphenyl)methyl]-6′-oxo-4′-(trifluoromethyl)-1′,6′-dihydro-2,2′-bipyridin-6-yl}-1H-indole-2-carboxylate; 
       Ethyl 6-(5-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-2-thienyl)-1H-indole-2-carboxylate; 
       1-[(2,4-Dimethylphenyl)methyl]-6-[5-(1H-indol-6-yl)-2-thienyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 
       Ethyl 5-(5-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-2-thienyl)-1H-indole-2-carboxylate; 
       1,1-Dimethylethyl 6-(5-{5-cyano-1-[(2,4-dimethylphenyl)methyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl}-2-thienyl)-1H-indole-1-carboxylate; and 
       6-[5-(1H-Benzimidazol-5-yl)-2-thienyl]-1-[(2,4-dimethylphenyl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile. 
     
     
         93 . A method of treating, preventing, or ameliorating the symptoms of a disease or disorder that is modulated or otherwise affected by nuclear receptor activity or in which nuclear receptor activity is implicated, comprising administering to a subject in need thereof an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         94 . The method of  claim 93 , wherein the disease or disorder is selected from hypercholesterolemia, hyperlipoproteinemia; hypertriglyceridemia, lipodystrophy, hyperglycemia, diabetes mellitus, dyslipidemia, atherosclerosis, gallstone disease, acne vulgaris, acneiform skin conditions, diabetes, Parkinson&#39;s disease, cancer, Alzheimer&#39;s disease, inflammation, immunological disorders, lipid disorders, obesity, conditions characterized by a perturbed epidermal barrier function, conditions of disturbed differentiation or excess proliferation of the epidermis or mucous membrane, and cardiovascular disorders. 
     
     
         95 . A method of reducing cholesterol levels in a subject in need thereof, comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         96 . A method of treating, preventing, or ameliorating one or more symptoms of a disease or disorder which is affected by cholesterol, triglyceride, or bile acid levels, comprising administering to a subject in need thereof an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         97 . A method of modulating nuclear receptor activity, comprising contacting one or more nuclear receptors with a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         98 . The method of  claim 97 , wherein at least one nuclear receptor is liver X receptor (LXRα or LXRβ). 
     
     
         99 . The method of  claim 97 , wherein at least one nuclear receptor is farnesoid X receptor (FXR) and another nuclear receptor is liver X receptor (LXRα and/or LXRβ). 
     
     
         100 . A method of modulating cholesterol metabolism, comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         101 . A method of treating, preventing or ameiliorating one or more symptoms of hypocholesterolemia in a subject in need thereof, comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         102 . A method of increasing cholesterol efflux from cells of a subject, comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         103 . A method of increasing the expression of ATP-Binding Cassette transport protein (ABC1) in the cells of a subject, comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         104 . A method of increasing the expression of ATP-Binding Cassette transport protein (ABCG1) in the cells of a subject, comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         105 . An in vitro method for altering nuclear receptor activity, comprising contacting the nuclear receptor with a compound of  claim 1 , or a pharmaceutically acceptable derivative thereof. 
     
     
         106 . The method of  claim 96 , wherein the disease or disorder, is selected from hypercholesterolemia, hyperlipoproteinemia, hypertriglyceridemia, lipodystrophy, hyperglycemia, diabetes mellitus, dyslipidemia, atherosclerosis, gallstone disease, acne vulgaris, acneiform skin conditions, diabetes, Parkinson&#39;s disease, cancer, Alzheimer&#39;s disease, inflammation, immunological disorders, lipid disorders, obesity, conditions characterized by a perturbed epidermal barrier function, conditions of disturbed differentiation or excess proliferation of the epidermis or mucous membrane, and cardiovascular disorders. 
     
     
         107 . A method of reducing cholesterol levels in a subject in need thereof, comprising administering an effective amount of a compound of  claim 1 . 
     
     
         108 . A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of  claim 1 .
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