US2008119569A1PendingUtilityA1

Polymer-based sustained release device

Assignee: ALKERMES INCPriority: Apr 15, 2004Filed: Jul 20, 2007Published: May 22, 2008

Est. expiryApr 15, 2024(expired)· nominal 20-yr term from priority

Inventors:Steven G. Wright Troy Christensen Thean Yeoh Michael E. Rickey Joyce M. Hotz Rajesh Kumar Mark S. Fineman Christine Smith John Ong David M. Lokensgard Henry R. Costantino

A61P 3/10A61P 9/00A61P 3/04A61K 9/5089A61K 31/573A61K 9/1694A61K 38/26A61K 47/34A61K 9/0002A61K 9/1647A61K 38/2278A61K 9/20

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References

Claims

Abstract

This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

Claims

exact text as granted — not AI-modified

1 . A composition suitable for the treatment of Type-2 diabetes, consisting essentially of:
 purified 50:50 DL PLG 4A polymer;   3 to 5% (w/w) exendin-4; and   2% (w/w) sucrose;   wherein the ratio of C max  to C ave  is about 3 or less and the total pore volume of the composition is about 0.1 mL/g or less.   
     
     
         2 . A method of treating a patient suffering from Type 2 diabetes, comprising:
 administering a therapeutically effective amount of the composition of  claim 1 .

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