Methods and compositions for treating post-cardial infarction damage

Abstract

Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.

1 . A device comprising:
 a) a first delivery needle, and   b) a second delivery needle,   c) whereby a first gel component can be delivered through the first delivery needle without contacting a second gel component that may be disposed in the second delivery needle.   
   
   
       2 . The device of  claim 1 , wherein the first delivery needle and the second delivery needle are arranged in a side-by-side configuration. 
   
   
       3 . The device of  claim 1 , wherein the first delivery needle and the second delivery needle are arranged in a coaxial configuration. 
   
   
       4 . The device of  claim 1 , further comprising a port disposed in the wall of the first delivery needle adapted such that a first gel component delivered through the port and a second gel component delivered through the second delivery needle will diverge. 
   
   
       5 . The device of  claim 2  adapted to have at least two configurations and wherein the distal end of the first delivery needle and the distal end of the second delivery needle are longitudinally separated by an offset distance. 
   
   
       6 . The device of  claim 5 , wherein the offset distance is less in a second configuration than in the first configuration. 
   
   
       7 . The device of  claim 6 , further including a biasing element associated with the first delivery needle and the second delivery needle, whereby the biasing element urges the device toward the first configuration. 
   
   
       8 . The device of  claim 7  wherein the biasing element is a spring. 
   
   
       9 . The device of  claim 8  wherein the spring is selected from the group consisting of compression, volute, Belleville, tension, v-spring and leaf-type springs. 
   
   
       10 . The device of  claim 3 , wherein the distal end of the first delivery needle and the distal end of the second delivery needle are longitudinally separated by an offset distance in a first configuration. 
   
   
       11 . The device of  claim 10  adapted to have at least two configurations and wherein the distal end of the first delivery needle and the distal end of the second delivery needle are longitudinally separated by an offset distance that is less in a second configuration than in the first configuration. 
   
   
       12 . The device of  claim 11 , further including a biasing element associated with the first delivery needle and the second delivery needle, whereby the biasing element urges the device toward the first configuration. 
   
   
       13 . The device of  claim 12  wherein the biasing element is a spring. 
   
   
       14 . The device of  claim 13  wherein the spring is selected from the group consisting of compression, volute, Belleville, tension, v-spring and leaf-type springs. 
   
   
       15 . The device of  claim 3 , wherein the second delivery needle includes at least two lumens separated from each other, and separated from the first needle lumen. 
   
   
       16 . The device of  claim 1 , wherein the proximal portion of the first delivery needle and second delivery needle have a larger lumen profile than the distal portion and the proximal portion connects to the distal portion through a transition portion. 
   
   
       17 . The device of  claim 16 , wherein the transition portion has a step, a taper, or a combination of a step and taper. 
   
   
       18 . A device comprising:
 a) a first delivery needle, and   b) a second delivery needle wherein a lumen at the second needle is separated from the lumen of the first needle,   c) an actuation element associated with a proximal edge of the second delivery needle,   d) a catheter shaft, and   e) a dynamic seal formed between the catheter shaft inner lumen and the second delivery needle,   f) whereby a first component can be delivered through the first delivery needle without contacting a second component disposed in the second delivery needle.   
   
   
       19 . A method of performing a medical procedure, comprising:
 a) advancing within a patient's body lumen a device comprising a first delivery needle, and a second delivery needle,   b) delivering a first gel component through the first delivery needle,   c) delivering a second gel component through the second delivery needle, and   d) allowing the first and second gel components to admix within the patient's body tissue to form a gel composition.   
   
   
       20 . The method of  claim 19  wherein the device is further adapted to have at least two configurations and wherein the distal end of the first needle and the distal end of the second needle are longitudinally separated by an offset distance.