Novel Goodpasture Antigen-Binding Protein Isoforms and Protein Misfolded-Mediated Disorders

Abstract

The present invention provides novel isoforms of the Goodpasture antigen binding protein (GPBP), and related reagents, and also provides methods for isolating and detecting such novel GPBP isoforms. The invention further provides methods identifying compounds to treat one or more of an autoimmune condition and a protein deposit-mediated disorder, as well as novel compounds and methods for treating such conditions and/or disorders.

1 .- 27 . (canceled) 
     
     
         28 . A method for treating a an autoimmune condition comprising administering to a subject in need thereof an amount effective to treat the disorder of a polypeptide comprising X1-SHCIX2-X3;
 wherein X1 is 0-10 amino acids of the sequence ATTAGILATL (SEQ ID NO:41);   X2 is E or Q; and   X2 is 0-10 amino acids of the sequence LMVKREDSWQ (SEQ ID NO:42).   
     
     
         29 .- 33 . (canceled) 
     
     
         34 . The method of  claim 28  wherein X2 is E. 
     
     
         35 . The method of  claim 28  wherein X2 is Q. 
     
     
         36 . The method of  claim 28  wherein X1 is ILATL. 
     
     
         37 . The method of  claim 28  wherein X3 is LMVKR. 
     
     
         38 . The method of  claim 28 , wherein the polypeptide comprises LATLSHCIELMVKR (SEQ ID NO:90). 
     
     
         39 . The method of  claim 28 , wherein the polypeptide consists of LATLSHCIELMVKR (SEQ ID NO:90). 
     
     
         40 . The method of  claim 39 , wherein the polypeptide comprises D amino acids. 
     
     
         41 . The method of  claim 28  wherein the autoimmune condition is selected from the group consisting of Goodpasture Syndrome, multiple sclerosis, systemic lupus erythematosus, cutaneous lupus erythematosus, pemphigus, pemphigoid and lichen planus.