US2008139452A1PendingUtilityA1
Secreted proteins and polynucleotides encoding them
Est. expiryAug 14, 2018(expired)· nominal 20-yr term from priority
Inventors:Kenneth JacobsJohn M. MccoyEdward R. LavallieLisa Collins-RacieDavid MerbergMichael AgostinoRobert SteiningerVikki SpauldingGordon G. WongHilary ClarkKim FechtelCheryl EvansMaurice Treacy
C07K 14/435C07K 16/18A61K 38/00A61P 43/00C07K 14/47
63
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Claims
Abstract
Novel polynucleotides and the proteins encoded thereby are disclosed.
Claims
exact text as granted — not AI-modified1 .- 13 . (canceled)
14 . A protein encoded by an isolated polynucleotide, said protein being produced by a process comprising:
(i) growing a culture of a host cell in a suitable culture medium, wherein the host cell has been transformed with said polynucleotide; and (ii) purifying said protein from the culture, wherein said polynucleotide is operably linked to at least one expression control sequence, and wherein said polynucleotide is selected from the group consisting of: (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:155; (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:155 from nucleotide 110 to nucleotide 742; (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:155 from nucleotide 170 to nucleotide 742; and (d) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:156.
15 . A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:156; (b) a fragment of the amino acid sequence of SEQ ID NO:156, the fragment comprising eight contiguous amino acids of SEQ ID NO:156; and (c) the amino acid sequence encoded by the cDNA insert of clone qv538 — 1 deposited under accession number ATCC 207187, the protein being substantially free from other mammalian proteins.
16 . The protein of claim 15 , wherein said protein comprises the amino acid sequence of SEQ ID NO:156.
17 . A composition comprising the protein of claim 15 and a pharmaceutically acceptable carrier.Join the waitlist — get patent alerts
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