Method For Control of Invasion and Use of Adiponectin

Abstract

Physical condition under stress can be controlled by using adiponectin in blood as a stress marker and measuring a level thereof. Moreover, endotoxin activity can be inhibited by using adiponectin.

1 . A method for control of invasion comprising using an adiponectin level in the blood as a stress marker and measuring the adiponectin level and a ratio of the adiponectin level after stress to the adiponectin level before stress. 
     
     
         2 . The method for control of invasion according to  claim 1 , wherein the control of invasion is a control of post operative infection in human. 
     
     
         3 . The method for control of invasion according to  claim 1 , wherein the control of invasion is a control of insulin resistance in human. 
     
     
         4 . The method for control of invasion according to  claim 2 , wherein the surgery is a transplantation treatment. 
     
     
         5 . The method for control of invasion according to  claim 2 , wherein the infection is sepsis, hypercytokinemia, or multiple organ failure. 
     
     
         6 . A system for control of invasion complying with a method for control of invasion according to  claim 1 . 
     
     
         7 . A method for creating a clinical path using the system for control of invasion according to  claim 6  as a subclass. 
     
     
         8 . A method for predicting post operative infection using the system for control of invasion according to  claim 6 . 
     
     
         9 . A method for measuring surgical stress in a patient with metabolic syndrome using a system for control of invasion according to  claim 6 . 
     
     
         10 . Adiponectin as a stress marker for sepsis. 
     
     
         11 . Adiponectin as a stress marker for hypercytokinemia. 
     
     
         12 . Adiponectin as a stress marker for multiple organ failure. 
     
     
         13 . Use of adiponectin as a stress marker in control of invasion. 
     
     
         14 . The use according to  claim 13 , wherein the adiponectin is used as a stress marker for sepsis, hypercytokinemia, or multiple organ failure. 
     
     
         15 . A method for analyzing stress factors comprising using adiponectin. 
     
     
         16 . The analyzing method according to  claim 15 , wherein the stress is stress due to sepsis, hypercytokinemia, or multiple organ failure. 
     
     
         17 . An endotoxin-neutralizing agent comprising human adiponectin in an amount effective for inhibiting endotoxin activity. 
     
     
         18 . The endotoxin-neutralizing agent according to  claim 17 , characterized in that the neutralizing agent has an adiponectin concentration of 0.1 to 100 μg/ml. 
     
     
         19 . The endotoxin-neutralizing agent according to  claim 17 , wherein the neutralizing agent is an adsorbent comprising the human adiponectin immobilized thereon. 
     
     
         20 . The endotoxin-neutralizing agent according to  claim 17 , wherein the neutralizing agent is used for the treatment of sepsis, medical diseases, or multiple organ failure. 
     
     
         21 . A treatment method for the diseases in need of inhibition of endotoxin activity comprising directly administering a neutralizing agent into the body according to  claim 18 . 
     
     
         22 . A treatment method, characterized in that the treatment method is a method wherein blood from the body is brought in vitro into contact with a neutralizing agent according to  claim 19  and then returned to the body. 
     
     
         23 . The treatment method according to  claim 21 , further comprising using together therewith a pharmaceutical drug increasing a human adiponectin concentration in the body. 
     
     
         24 . The treatment method according to  claim 21 , wherein the treatment is used for sepsis, medical diseases, or multiple organ failure.