US2008139791A1PendingUtilityA1
Pharmaceutically acceptable Fn3 Polypeptides for human treatments
Est. expiryDec 10, 2018(expired)· nominal 20-yr term from priority
C12Q 1/00C07K 2319/00C40B 40/02C07K 16/241C07K 2318/20C07K 14/78C07K 2319/30C07K 2317/22C07K 16/00C12N 15/1037C07K 14/525C07K 14/47
70
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Claims
Abstract
Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
Claims
exact text as granted — not AI-modified1 . A non-antibody protein comprising a domain having an immunoglobulin-like fold, said non-antibody protein deriving from a reference protein by having a mutated amino acid sequence wherein said non-antibody protein binds with a Kd at least as tight as 1 μM to a compound that is not bound as tightly by said reference protein.
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