Adding microscopic porosity to the surface of a microcoil to be used for medical implantation

Abstract

A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.

1 . A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature, comprising:
 a vasoocclusive microcoil including a radiopaque metal wire, said microcoil including at least a portion having an outer surface adapted to contact the tissue of a patient to be treated, the outer surface of said microcoil defining a plurality of pores having a complex shape therein; and   a therapeutic material disposed within said plurality of pores in said outer surface of said microcoil, wherein said therapeutic material comprises a material selected from the group consisting of a hydrogel and a plastic agent which can act to accelerate the healing process once the coil is in place.   
     
     
         2 . The vasoocclusive microcoil of  claim 1 , wherein said therapeutic material is selected from the group consisting of polyglycolic acid and poly(D,L-lactic acid-co-glycolic acid). 
     
     
         3 . The vasoocclusive microcoil of  claim 1 , wherein said therapeutic material is selected from the group consisting of silk, collagen, elastin, polyglycolic acid, polylactic acid, poly(D,L-lactic acid-co-glycolic acid), poly(L-lactide), poly(L-lactide-co-D,L-lactide), poly(L-lactide-co-glycolide), poly(glycolide-co-trimethylene carbonate), polyethylene oxide, polydioxanone, polycaprolactone, hylauric acid, polyhydroxylbutyrate, poly(phosphazene), poly(D,L-lactide-co-caprolactone), poly(glycolide-co-caprolactone), polyvinyl alcohol, polyanhydrides thereof, poly(ortho esters) thereof, poly(phosphate esters) thereof, poly(amino acids) thereof, poly(hydroxy butyrates) thereof, copolymers thereof, composites thereof, and combinations thereof. 
     
     
         4 . The vasoocclusive microcoil of  claim 1 , wherein said therapeutic material is selected from the group consisting of ethylene-octene copolymer, polypropylene, polyethylene, polyacrylate, polyacrylamide, poly(hydroxyethyl methacrylate), polyurethane, polysiloxane, copolymers thereof, composites thereof, and combinations thereof. 
     
     
         5 . The vasoocclusive microcoil of  claim 1 , wherein said therapeutic material comprises a therapeutic drug. 
     
     
         6 . A method for occluding a patient's vasculature, comprising:
 providing a vasoocclusive microcoil including a radiopaque metal wire, said microcoil including at least a portion having an outer surface adapted to contact the tissue of a patient to be treated, the outer surface of said microcoil defining a plurality of pores having a complex shape therein, and a therapeutic material disposed within said plurality of pores in said outer surface of said microcoil, wherein said therapeutic material comprises a material selected from the group consisting of a hydrogel and a plastic agent which can act to accelerate the healing process once the coil is in place; and   introducing said vasoocclusive microcoil into the patient's vasculature, whereby said therapeutic material can act to accelerate a healing process in the patient's vasculature.   
     
     
         7 . The method of  claim 6 , wherein said therapeutic material is selected from the group consisting of polyglycolic acid and poly(D,L-lactic acid-co-glycolic acid). 
     
     
         8 . The method of  claim 6 , wherein said therapeutic material is selected from the group consisting of silk, collagen, elastin, polyglycolic acid, polylactic acid, poly(D,L-lactic acid-co-glycolic acid), poly(L-lactide), poly(L-lactide-co-D,L-lactide), poly(L-lactide-co-glycolide), poly(glycolide-co-trimethylene carbonate), polyethylene oxide, polydioxanone, polycaprolactone, hylauric acid, polyhydroxylbutyrate, poly(phosphazene), poly(D,L-lactide-co-caprolactone), poly(glycolide-co-caprolactone), polyvinyl alcohol, polyanhydrides thereof, poly(ortho esters) thereof, poly(phosphate esters) thereof, poly(amino acids) thereof, poly(hydroxy butyrates) thereof, copolymers thereof, composites thereof, and combinations thereof. 
     
     
         9 . The method of  claim 6 , wherein said therapeutic material is selected from the group consisting of ethylene-octene copolymer, polypropylene, polyethylene, polyacrylate, polyacrylamide, poly(hydroxyethyl methacrylate), polyurethane, polysiloxane, copolymers thereof, composites thereof, and combinations thereof. 
     
     
         10 . The method of  claim 6 , wherein said therapeutic material comprises a therapeutic drug.