US2008160037A1PendingUtilityA1

Novel beta-defensins

71
Assignee: ZYMOGENETICS INCPriority: Sep 10, 1997Filed: Jun 15, 2007Published: Jul 3, 2008
Est. expirySep 10, 2017(expired)· nominal 20-yr term from priority
Inventors:David AdlerJames HollowayNand BaindurStephanie Beigel-OrmePaul O. Sheppard
A61K 38/00A61P 37/00C07K 14/4723Y02A50/30
71
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Claims

exact text as granted — not AI-modified
1 . A purified antibody which specifically binds to a polypeptide consisting of an amino acid sequence that is at least 95% identical to amino acid residues 23 to 67 of SEQ ID NO:10. 
     
     
         2 . The antibody of  claim 1  wherein the polypeptide consists of amino acid residues 23 to 67 of SEQ ID NO:10. 
     
     
         3 . The antibody of  claim 1  wherein the antibody is a polyclonal antibody. 
     
     
         4 . The antibody of  claim 1  wherein the antibody is a monoclonal antibody. 
     
     
         5 . The antibody of  claim 1  wherein the antibody is an antibody fragment. 
     
     
         6 . The antibody of  claim 5  wherein the antibody fragment is F(ab′) 2 . 
     
     
         7 . The antibody of  claim 5  wherein the antibody fragment is Fab. 
     
     
         8 . The antibody of  claim 5  wherein the antibody fragment is Fv. 
     
     
         9 . The antibody of  claim 5  wherein the antibody fragment is a single chain antibody. 
     
     
         10 . The antibody of  claim 1  wherein the antibody is a chimeric antibody. 
     
     
         11 . The antibody of  claim 1  wherein the antibody is a humanized antibody. 
     
     
         12 . A method of producing an antibody comprising:
 inoculating an animal with a polypeptide, wherein the polypeptide consists amino acid residues 23 to 67 of SEQ ID NO:10, and wherein the polypeptide elicits an immune response in the animal to produce the antibody; and   isolating the antibody from the animal.   
     
     
         13 . The antibody produced by the method of  claim 12  wherein the antibody binds to the polypeptide consisting amino acid residues 23 to 67 of SEQ ID NO:10. 
     
     
         14 . The antibody produced by the method of  claim 12  wherein the antibody is a polyclonal antibody.

Join the waitlist — get patent alerts

Track US2008160037A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.