Liquid concentrate for the preservation of cosmetic and pharmaceutical products

Abstract

The invention relates to a liquid concentrate for the preservation of cosmetic an pharmaceutical prod nets which comprises 3-iodo-2-propynyl butylcarbamate (IPBC), at least on liquid carrier selected from the group consisting of: polyvalent alcohols, glycol esters and glycol ethers, and at least one stabilizer selected from the group consisting of: formic acid, formic acid salts, and format esters, and comprising no additional carboxylic acid selected from the group consisting of: benzoic acid, propionic acid, salicylic acid, sorbic acid, 4-hydroxybenzoic acid, dehydroacetic acid and 10-undecylenic acid and a salt thereof being present.

1 . A method for preserving cosmetic and pharmaceutical products comprising the steps of:
 providing a liquid concentrate preservative comprising:   a) 3-iodo-2-propynyl butylcarbamate (IPBC).   b) at least one liquid carrier,   c) at least one stabilizer, and   d) polyhexamethylene biguanide, or a salt thereof; and   mixing said concentrate in a cosmetic or pharmaceutical product by simple dilution, wherein,   the weight ratio of said IPBC to said polyhexamethylene biguanide is from about 100:1 to about 1:100, and   no additional carboxylic acid chosen from benzoic acid, propionic acid, salicylic acid, sorbic acid, 4-hydroxybenzoic acid, dehydroacetic acid, and 10-undecylenic acid, or the salts thereof, is present in said concentrate.   
     
     
         2 . The method according to  claim 1 , wherein said IPBC is from about 0.01% to about 20% by weight of said concentrate. 
     
     
         3 . The method according to  claim 1 , wherein said liquid carrier comprises at least one component selected from the group consisting of polyvalent alcohols, glycol esters, and glycol ethers. 
     
     
         4 . The method according to  claim 3 , wherein said polyvalent alcohol is at least one component selected from the group consisting of diol, glycol, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 1,2-pentanediol, 1,3-pentanediol. 1,4-pentanediol, 1,5-pentanediol, glycol ester, glycol ether, ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, triethylene glycol, and 1,2-propylene glycol. 
     
     
         5 . The method according to  claim 1 , wherein said stabilizer comprises at least one component selected from the group consisting of formic acid, formate salts, formate esters, sodium formate, potassium formate, and formic acid propylene glycol monoester, diester, and formate esters formed in situ. 
     
     
         6 . The method according to  claim 5 , wherein said stabilizer consists of formic acid. 
     
     
         7 . The method according to  claim 1 , wherein said stabilizer is from about 0.001% to about 20% by weight of said concentrate. 
     
     
         8 . The method according to  claim 1 , wherein said concentrate further comprises a component selected from the group consisting of at least one functional additive, at least one auxiliary, and mixtures thereof. 
     
     
         9 . The method according to  claim 1 , wherein said polyhexamethylene biguanide is up to about 20% by weight of said concentrate. 
     
     
         10 . The method according to  claim 1 , wherein said weight ratio ranges from about 10:1 to about 1:10. 
     
     
         11 . The method according to  claim 1 , wherein said IPBC is less than about 1% by weight of said concentrate, and said polyhexamethylene biguanide is less than about 1% by weight of said concentrate. 
     
     
         12 . The method according to  claim 1 , wherein,
 said concentrate further comprises at least one functional additive, and   said concentrate is absent an auxiliary.   
     
     
         13 . The method according to  claim 8 , wherein said auxiliary comprises water. 
     
     
         14 . The method according to  claim 13 , wherein said water is from about 0.01% to about 10% by weight of the concentrate. 
     
     
         15 . The method according to  claim 8 , wherein said concentrate further comprises a paraben. 
     
     
         16 . The method according to  claim 8 , wherein said concentrate further comprises a quaternary ammonium compound. 
     
     
         17 . The method according to  claim 8 , wherein said concentrate further comprises a halogen compound. 
     
     
         18 . The method according to  claim 8 , wherein said concentrate further comprises an amidine compound. 
     
     
         19 . The method according to  claim 8 , wherein said concentrate further comprises isothiazolone. 
     
     
         20 . The method according to  claim 8 , wherein said concentrate further comprises benzalkonium salt. 
     
     
         21 . The method according to  claim 8 , wherein said concentrate further comprises formaldehyde or a formaldehyde-depositing compound or a salt thereof. 
     
     
         22 . The method according to  claim 8 , wherein said concentrate further comprises at least one of phenoxyethanol, phenoxypropanol, and benzyl alcohol.