Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile

Abstract

The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.

1 . (canceled) 
     
     
         2 . A compound consisting of 3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline. 
     
     
         3 . A compound consisting of 4-Chloro-3-cyano-7-ethoxy-6-N-acetylquinoline. 
     
     
         4 - 15 . (canceled) 
     
     
         16 . A process for the preparation of 3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline by heating 3-(4-Acetamido-3-ethoxyaniline)-2-cyano-propenoic acid ethyl ester. 
     
     
         17 . The process of  claim 16  further comprising converting 3-Cyano-7-ethoxy-4-hydroxy-6-N-acetylquinoline to 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile or a pharmaceutically acceptable salt form thereof.