Methods and materials for stimulating proliferation of stem cell

Abstract

Disclosed herein are methods and materials for influencing proliferation of stem cells. Specifically exemplified herein are compositions comprising cerium oxide nanoparticles which can be used to stimulate proliferation of stem cells under common culture conditions, or which can be utilized to improve therapeutic outcomes.

1 . A method of influencing proliferation of stem cells in a body comprising
 administering stem cells to a body; and   administering a composition comprising cerium oxide to said body, wherein said stem cells and said composition are placed in said body such that said migration influencing factor is brought into contact with at least one of said stem cells.   
     
     
         2 . The method of  claim 2 , wherein said composition is an admixture of cerium oxide and a pharmaceutically acceptable carrier. 
     
     
         3 . The method of  claim 2 , wherein said pharmaceutically acceptable carrier comprises water. 
     
     
         4 . The method of  claim 1 , wherein said composition is administered via an intravenous, intraarterial, or intramuscular route of administration. 
     
     
         5 . A method of stimulation proliferation of a population of stem cells comprising contacting said population with cerium oxide nanoparticles, wherein said contacting occurs in vitro, in vivo, in situ and/or ex vivo. 
     
     
         6 . The method of  claim 5 , wherein said nanoparticles are of a size from about 0.5 nm to about 50 nm. 
     
     
         7 . The method of  claim 6 , wherein said nanoparticles are spherical shaped and about 3-5 nm in size. 
     
     
         8 . The method of  claim 6  wherein said nanoparticles are spherical in shape and about 10-20 nm in size. 
     
     
         9 . The method of  claim 6 , wherein said nanoparticles comprise agglomerates of 3-5 nm sized individual crystals. 
     
     
         10 . The method of  claim 6 , wherein said nanoparticles are spherical in shape and about 11-15 nm in size. 
     
     
         11 . The method of  claim 6 , wherein said nanoparticles are spherical in shape and about 7-10 nm in size. 
     
     
         12 . The method of  claim 6 , wherein said nanoparticles are cuboidal in shape and about 10-20 nm in size. 
     
     
         13 . A method of treating or preventing a neurological or corporal deficit comprising administering a therapeutically effective amount of cerium oxide nanoparticles. 
     
     
         14 . The method of  claim 13 , wherein said composition is administered via parenteral administration. 
     
     
         15 . The method of  claim 13 , wherein parenteral administration comprises intramuscular, intravenous, intracistern, intraventrical, intraarterial, or local administration. 
     
     
         16 . The method of  claim 13 , wherein said administration comprises, rectal administration. 
     
     
         17 . The method of  claim 13 , wherein said administration comprises topical administration. 
     
     
         18 . The method of  claim 13 , wherein said administration comprises dermal or ocular. 
     
     
         19 . The method of  claim 13 , wherein said composition is administered via oral administration.