Methods, Compositions and Articles of Manufacture for Enhancing Survivability of Cells, Tissues, Organs, and Organisms

Abstract

The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

1 . A method for enhancing survivability of biological matter comprising providing to the biological matter an effective amount of at least one active compound. 
     
     
         2 . The method of  claim 1 , wherein the active compound is an oxygen antagonist. 
     
     
         3 . The method of  claim 1 , wherein the matter is exposed to the active compound. 
     
     
         4 . The method of  claim 1 , wherein the active compound is a chalcogenide. 
     
     
         5 . The method of  claim 1 , wherein the active compound has a chemical structure of Formula I or Formula IV. 
     
     
         6 . The method of  claim 5 , wherein the matter is exposed to a precursor of a chemical structure of Formula I or Formula IV. 
     
     
         7 . The method of  claim 1 , wherein the matter is provided with a combination of active compounds. 
     
     
         8 . The method of  claim 1 , wherein the matter is provided with the active compound before, during, or after an injury, the onset or progression of a disease, or hemorrhaging in the matter. 
     
     
         9 . The method of  claim 8 , wherein the injury involves hemorrhaging. 
     
     
         10 . The method of  claim 9 , wherein the injury is from an external physical source. 
     
     
         11 . The method of  claim 8 , wherein the active compound is provided before the injury or before the onset or progression of the disease. 
     
     
         12 . The method of  claim 8 , wherein the injury or disease is associated with a reduction in metabolism or temperature of the matter. 
     
     
         13 . The method of  claim 12 , wherein the injury is a surgery. 
     
     
         14 .- 149 . (canceled)