Survivin-binding proteins, encoding nucleic acids, and methods of use

Abstract

In accordance with the present invention, there are provided novel Survivin-binding-proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SBPs can be employed in a variety of ways, for example, for the production of anti-SBP antibodies thereto, in therapeutic compositions and in bioassays methods employing such proteins and/or antibodies. Also provided are transgenic non-human mammals that express the invention protein.

1 - 12 . (canceled) 
     
     
         13 . An isolated antibody having specific reactivity with an SBP1 polypeptide comprising the amino acid sequence set forth as SEQ ID NO:14. 
     
     
         14 . The antibody of  claim 13 , wherein said antibody is a monoclonal antibody. 
     
     
         15 . A cell line producing the monoclonal antibody of  claim 14 . 
     
     
         16 . The antibody of  claim 13 , wherein said antibody is a polyclonal antibody. 
     
     
         17 - 34 . (canceled)