Method for the treatment of acne

Abstract

A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.

1 . A method of preparing an oral dosage form for administration once a day that provides a continuous release of an oral minocycline, comprising: 
 combining an antibiotically effective dose of said oral minocycline and a pharmaceutically suitable delivery vehicle having a fast dissolving carrier and a slow dissolving carrier to form a combination, said fast dissolving carrier and said slow dissolving carrier having a weight ratio of about 0.3 to about 0.5 of fast dissolving carrier to slow dissolving carrier;    wherein said oral dosage form upon administration releases said oral minocycline to provide a patient with about 0.5 mg/kg/day to about 1.5 mg/kg/day of said oral minocycline.    
     
     
         2 . The method of  claim 1 , wherein said oral minocycline is minocycline as hydrochloride.  
     
     
         3 . The method of  claim 1 , wherein the weight ratio of fast dissolving carrier to slow dissolving carrier is about 0.35 to about 0.45.  
     
     
         4 . The method of  claim 1 , wherein the weight ratio of fast dissolving carrier to slow dissolving carrier is about 0.36 to about 0.40.  
     
     
         5 . The method of  claim 1 , wherein said fast dissolving carrier comprises lactose monohydrate.  
     
     
         6 . The method of  claim 1 , wherein said slow dissolving carrier comprises HPMC.  
     
     
         7 . The method of  claim 1 , wherein: 
 said fast dissolving carrier comprises lactose monohydrate; and    said slow dissolving carrier comprises HPMC.    
     
     
         8 . The method of  claim 1 , wherein said slow dissolving carrier is present at about 23.5 to about 27.0% by weight of the oral dosage form.  
     
     
         9 . The method of  claim 1 , wherein said slow dissolving carrier is present at: 
 23.5% by weight of said oral dosage form when said oral dosage form comprises 135 mg of said oral minocycline; or    27.0% by weight of said oral dosage form when said oral dosage form comprises 45 mg of said oral minocycline.    
     
     
         10 . The method of  claim 1 , wherein compressing said combination forms said oral dosage form into a tablet.  
     
     
         11 . (canceled)  
     
     
         12 . The method of  claim 1 , further comprising an intragranular fast dissolving carrier.  
     
     
         13 . The method of  claim 12 , wherein said slow dissolving carrier encapsulates at least a portion of said intragranular fast dissolving carrier.  
     
     
         14 . The method of  claim 1 , further comprising adding a coating to said combination to form said oral dosage form.  
     
     
         15 . The method of  claim 1 , further comprising compressing said combination.