Method for the treatment of acne

Abstract

A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.

1 . A method of treating acne vulgaris, comprising administering to a person suffering from acne vulgaris a continuous slow release oral dosage form comprising: 
 an antibiotically effective amount of an oral minocycline antibiotic;    a fast dissolving carrier; and    a slow dissolving carrier, wherein said fast dissolving carrier to said slow dissolving carrier is at a weight ratio of about 0.3 to about 0.5;    wherein said continuous slow release oral dosage form provides, upon administration once daily without a loading dose, the person with about 0.5 mg/kg/day to about 1.5 mg/kg/day of said oral minocycline antibiotic.    
     
     
         2 . The method of  claim 1 , wherein said continuous slow release oral dosage form provides the person with about 0.7 mg/kg/day to about 1.3 mg/kg/day of said oral minocycline antibiotic.  
     
     
         3 . The method of  claim 1 , wherein said continuous slow release oral dosage form provides the person with about 1.0 mg/kg/day of said oral minocycline antibiotic.  
     
     
         4 . (canceled)  
     
     
         5 . The method of  claim 1 , wherein said oral minocycline antibiotic is minocycline as hydrochloride.  
     
     
         6 . (canceled)  
     
     
         7 . The method of  claim 1 , wherein said continuous slow release oral dosage form releases said oral minocycline antibiotic so that said oral minocycline antibiotic reaches a C max  in the person's blood between about 2.75 hours and about 4.0 hours after administration.  
     
     
         8 . The method of  claim 7 , wherein the C max  is reached between about 3.0 hours and about 3.75 hours after administration.  
     
     
         9 . The method of  claim 1 , wherein said weight ratio of fast dissolving carrier to slow dissolving carrier in said continuous slow release oral dosage form is from about 0.35 to about 0.45.  
     
     
         10 . The method of  claim 1 , wherein said weight ratio of fast dissolving carrier to slow dissolving carrier in said continuous slow release oral dosage form is from about 0.36 to about 0.40.  
     
     
         11 . The method of  claim 1 , wherein said continuous slow release oral dosage form further comprises an intragranular fast dissolving carrier.  
     
     
         12 . The method of  claim 11 , wherein said slow dissolving carrier encapsulates said intragranular fast dissolving carrier.  
     
     
         13 . The method of  claim 1 , wherein said continuous slow release oral dosage form comprises a coating.  
     
     
         14 . The method of  claim 1 , wherein said continuous slow release oral dosage form releases said oral minocycline antibiotic at a rate of about 25 to about 52% within about 1 hour, about 53 to about 89% within about 2 hours, and at least about 90% within about 4 hours.  
     
     
         15 . The method of  claim 1 , wherein said continuous slow release oral dosage form releases said oral minocycline antibiotic at a rate of about 30 to about 52% within about 1 hour, about 53 to about 84% within about 2 hours, and at least about 85% within about 4 hours.  
     
     
         16 . The method of  claim 7 , wherein the C max  is reached at about 3.5 hours after administration.