Pharmaceutical Preparation Containing Gabapentin

Abstract

A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80° C. and pharmaceutical compositions containing it, are described.

1 . A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80° C. 
     
     
         2 . The granulate according to  claim 1 , wherein the gabapentin is present in an amount higher than 80% by weight. 
     
     
         3 . A granulate according to  claim 1 , wherein the gabapentin is present in quantities higher than 90% by weight. 
     
     
         4 . A granulate according to  claim 1 , wherein the gabapentin is present in quantities equal to 98% by weight, the PEG being 2%. 
     
     
         5 . A gabapentin pharracutical composition under tablet form obtained by compressing a granulate according to  claim 1 . 
     
     
         6 . A gabapentin pharmaceutical composition under capsule form obtained by filling-in a gelatine capsule with a granulate according to  claim 1 . 
     
     
         7 . A gabapentin pharmaceutical composition under the tablet form obtained by compressing a granulate according to  claim 1  and known additives useful for the preparation of tablets. 
     
     
         8 . A gabapentin pharmaceutical composition under tablet form according to  claim 7 , wherein the additives are chosen among diluents, lubricants, disgregants and glydants. 
     
     
         9 . A gabapentin pharmaceutical composition under tablet form according to  claim 7 , wherein the additives represent between 0 and 30% by weight and preferably between 0 and 20% by weight of the tablet, the remaining to 100% being a granulate of  claim 1 . 
     
     
         10 . A gabapcntin pharmaceutical composition under capsule form obtained by filling-in a gelatine capsule with a granulate according to  claim 1  and known additives useful for the preparation of pharmaceutical forms in capsule. 
     
     
         11 . A gabapentin pharmaceutical composition under the capsule form according to  claim 10 , wherein the additives represent between 0 and 30% by weight and preferably between 0 and 20% by weight of the capsule content, the remaining to 100% being a granulate of  claim 1 . 
     
     
         12 . A gabapentin granulate obtained by granulating gabapentin with PEG having a melting point comprised between 50 and 80° C. and additives known for the preparation of solid pharmaceutical forms chosen among tablets and capsules. 
     
     
         13 . A gabapentin granulate obtained by granulating gabapentin according to  claim 12 , wherein the additives are chosen among diluents, lubricants, disgregants and glydants. 
     
     
         14 . A granulate according to  claim 12  having the following composition: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   gabapentin 
                   80-98% by weight  
                 
                     
                   PEG 
                   2-25% by weight 
                 
                     
                   additives 
                   0-20% by weight 
                 
                     
                     
                 
             
                
               
               
                
                
                
                
               
            
           
         
       
     
     
         15 . A gabapentin pharmaceutical composition under tablet form obtained by compressing a granulate according to  claim 12 . 
     
     
         16 . A gabapentin pharmaceutical composition under capsule form obtained by filling-in a gelatine capsule with a granulate according to  claim 12 . 
     
     
         17 . A gabapentin chemical composition under tablet or capsule form containing a granulate according to  claim 1 . 
     
     
         18 . A gabapentin chemical composition under tablet or capsule form containing a granulate according to  claim 12 .