US2008194697A1PendingUtilityA1
Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
Est. expiryApr 30, 2019(expired)· nominal 20-yr term from priority
A61P 43/00A61P 35/00C07D 493/04C07K 5/1013A61P 15/00C07D 311/92C07D 295/185C07D 207/34C07D 317/70A61P 13/08A61K 38/00C07K 7/06C07D 307/92A61K 47/65C07C 2601/02C07C 211/18C07D 235/18C07C 67/343C07D 219/10C07D 307/79C07C 45/46C07C 211/13
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Claims
Abstract
Peptide conjugates in which cytostatic and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
Claims
exact text as granted — not AI-modified1 - 37 . (canceled)
38 . A method of treating cancer, comprising administering to an individual a therapeutic amount of one or more of the compounds:
and all salts and stereoisomers thereof.
39 . The method of claim 38 , wherein the compound is of the formula:
and all salts and stereoisomers thereof.
40 . The method of claim 38 , wherein the compound is of the formula:
and all salts thereof.
41 . The method of claim 38 , wherein the compound is of the formula:
and all salts thereof.
42 . The method of claim 38 , wherein the cancer is prostate cancer.
43 . The method of claim 38 , wherein the cancer is breast cancer.
44 . The method of claim 38 , wherein the cancer is brain cancer.
45 . The method of claim 38 , wherein the cancer is colon cancer.
46 . The method of claim 38 , wherein the cancer is lung cancer.Cited by (0)
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