Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same

Abstract

A compound represented the general formula (V): wherein X is CH or N; and Y a is a group of the general formula selected from:

1 . A compound represented the general formula (V): 
       
         
           
           
               
               
           
         
       
       wherein
 X is CH or N; and 
 Y a  is a group of the general formula (VI) 
 
       
         
           
           
               
               
           
         
       
       or a group of the general formula (VI-a): 
       
         
           
           
               
               
           
         
       
       or a group of the general formula (VII): 
       
         
           
           
               
               
           
         
       
       or a group of the general formula (VIII): 
       
         
           
           
               
               
           
         
       
       wherein
 a, b and c are each an integer of 0-6; 
 Z is CH 2  or NH; 
 W is O or S; 
 T is O or N—R 15  wherein R 15  is H, C1-C6 alkyl group, a benzyl group or a phenethyl group; 
 R 9  is H, a C1-C6 alkoxycarbonyl group, a benzyloxy-carbonyl group, a carboxy group, a 2-phenyl-1,3-dioxan-5-yl group, a 2,2-dimethyl-1,3-dioxan-5-yl group or a group of the general formula (IX); and 
 R 10  is H or a group of the general formula (IX): 
 
       
         
           
           
               
               
           
         
       
       wherein
 d is an integer of 0-6; and 
 R 11 , R 12 , and R 13  may be the same or different and are each independently H or —(CH 2 ) e R 14  wherein e is 0-6, and R 14  is a C1-C6 alkanoyloxy group, a benzoyloxy group, a 2-furoyloxy group, a C1-C6 alkoxy C1-C6 alkoxy group, a di C1-C6 alkanoyloxy C1-C6 alkylphenoxy group, a C1-C6 alkyldiarylsiloxy group, a C1-C6 alkoxycarbamoyl group, a carboxy group, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, a cyano group, a C1-C6 alkylsulfonamido group, a C1-C6 alkoxycarbonylphenoxy group or a di C1-C6 alkoxycarbonylphenoxy group.