Separation of fluorous compounds

Abstract

A method of separating at least a first non-fluorous compound from a mixture of compounds including at least the first non-fluorous compound and a second fluorous compound includes: charging the of compounds to a non-fluorous solid (stationary) phase and eluting with a fluorous eluting fluid (mobile phase). In one embodiment, the non-fluorous solid phase is polar in nature. The method can further include a second phase elution with a suitable organic solvent. A method conducting a chemical reaction, includes: mixing at least a first fluorous compound and a second compound, the first fluorous compound differing in fluorous nature from the second compound; exposing the first mixture to conditions to convert at least one of the first fluorous compound and the second compound to give a second mixture containing at least a third compound, charging the second mixture to a non-fluorous solid phase; and eluting with a fluorous fluid

1 . A method of conducting a chemical reaction, comprising:
 mixing at least a first fluorous compound and a second compound, the first fluorous compound differing in fluorous nature from the second compound;   exposing the first mixture to conditions to convert at least one of the first fluorous compound and the second compound to give a second mixture containing at least a third compound,   charging the second mixture to a non-fluorous solid phase;   and eluting with a fluorous fluid.   
     
     
         2 . The method of  claim 1  further comprising the step of eluting with an organic fluid after eluting with a fluorous fluid. 
     
     
         3 . A method of separating a first organic compound from a mixture comprising at least a second organic compound, the method comprising the steps of:
 selectively reacting the first organic compound with a fluorous reaction component to attach a fluorous moiety to the first organic compound to result in a fluorous compound;   separating the fluorous compound from the second organic compound by charging the mixture to a non-fluorous solid phase and eluting with a fluorous fluid.   
     
     
         4 . A method of synthesizing an organic target product comprising the steps of:
 reacting a first organic compound with a first fluorous reaction component to attach a fluorous moiety to the first organic compound to result in a second fluorous reaction component;   reacting the second fluorous reaction component in a reaction scheme including at least one reaction with at least a second organic compound to produce a fluorous target product in a reaction mixture; and   separating the fluorous target product from any excess second organic compound and any organic byproduct by charging the reaction mixture to a non-fluorous solid phase and eluting with a fluorous fluid.   
     
     
         5 . The method of  claim 4  further comprising the step of reacting the fluorous target product to cleave the fluorous moiety and generate the organic target product. 
     
     
         6 - 9 . (canceled)