US2008199497A1PendingUtilityA1

Pharmaceutical Composition Comprising Botulinum Toxin for Treating Knee Joint Pain by Saphenous Nerve Entrapment

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Assignee: IPSEN LTDPriority: Jun 28, 2004Filed: Jun 27, 2005Published: Aug 21, 2008
Est. expiryJun 28, 2024(expired)· nominal 20-yr term from priority
Inventors:Kang Ahn
A61P 29/02A61P 29/00A61P 25/04A61P 19/02A61P 19/00A61K 38/4893A61K 38/16A61K 38/17
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Claims

Abstract

There is provided a pharmaceutical composition comprising botulinum toxin and a pharmacologically acceptable carrier for treating pain in the knee joint caused by saphenous nerve entrapment. The composition of the present invention is for subcutaneous injection above the medial side of the knee.

Claims

exact text as granted — not AI-modified
1 . A pharmaceutical composition comprising botulinum toxin and a pharmacologically acceptable carrier for treating knee joint pain caused by saphenous nerve entrapment, the composition being for subcutaneous injection above the medial side of the knee. 
     
     
         2 . The composition of  claim 1  wherein the composition comprises about 20 to 200 LD 50  units of the botulinum toxin. 
     
     
         3 . The composition of  claim 1  wherein the composition is injected into a sub-cutaneous fascia, which has densely close hypersensitive receptors, located at the saphenous nerve-dominating area above the medial side of the knee. 
     
     
         4 . The composition of  claim 1  wherein the botulinum toxin is a botulinum toxin type A. 
     
     
         5 . The composition of  claim 1  wherein the effect of treating the knee joint pain is persistently maintained at least for 4 weeks.

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