US2008200465A1PendingUtilityA1
Antipathogenic benzamide compounds
Assignee: GENESOFT PHARMACEUTICALS INCPriority: Jun 13, 2001Filed: Jan 25, 2008Published: Aug 21, 2008
Est. expiryJun 13, 2021(expired)· nominal 20-yr term from priority
C07D 401/12C07D 401/14C07D 403/14A61P 31/04C07D 403/04C07D 413/14C07D 207/42C07D 409/04A61P 33/02C07D 409/14C07D 417/14A61P 31/12C07D 217/26C07D 417/04
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Claims
Abstract
The present invention is related to methods of treating viral and protozoan infections in mammals using antipathogenic benzamide compounds having the formula wherein at least one of the R 1 groups is F, Cl, CN or CF 3 and R 2 , R 3 , Y, Z, m, and n are as defined herein.
Claims
exact text as granted — not AI-modified1 - 28 . (canceled)
29 . A method of treating a viral infection in a mammal, comprising administering to a patient in need of such treatment an effective amount of a compound having the formula
wherein i is 3;
one of X 1 , X 2 , and X 3 is a ring vertex selected from the group consisting of —O—, —S—, and —NR 2 —, and the other two of X 1 , X 2 , and X 3 are ring vertices selected from the group consisting of ═N— and ═CR 4 —, wherein each moiety
is the same or different and at least one moiety is other than
each R 1 is independently H, F, Cl, CN, CF 3 , OH, N(R 2 ) 2 , OR 2 or a substituted or unsubstituted (C 1 -C 12 )alkyl group, with the proviso that at least one R 1 is F, Cl, CN or CF 3 ;
each R 2 and R 3 is independently H or a substituted or unsubstituted (C 1 -C 12 )alkyl group;
each R 4 is independently H, F, Cl, Br, I, CN, OH, NO 2 , NH 2 , or a substituted or unsubstituted (C 1 -C 12 )alkyl group;
Z(R 2 ) n is
r is an integer ranging from 2 to 8, inclusive;
each R 25 is independently selected from the group consisting of H, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , or CH(CH 3 ) 2 ;
said compound having at least one basic group having a pK b of 12 or less or a quaternized nitrogen group.
30 . A method according to claim 29 , wherein
is selected from the group consisting of
31 . A method according to claim 29 , wherein the moiety
which is other than
is selected from the group consisting of
32 . A method according to claim 29 , wherein each R 1 is independently H, F or Cl;
i is 3; two of said moiety
33 . A method according to claim 29 , wherein the compound has the formula:
34 . A method of treating a protozoan infection in a mammal, comprising administering to a patient in need of such treatment an effective amount of a compound having the formula
wherein i is 3;
one of X 1 , X 2 , and X 3 is a ring vertex selected from the group consisting of —O—, —S—, and —NR 2 —, and the other two of X 1 , X 2 , and X 3 are ring vertices selected from the group consisting of ═N— and ═CR 4 —, wherein each moiety
is the same or different and at least one moiety is other than
each R 1 is independently H, F, Cl, CN, CF 3 , OH, N(R 2 ) 2 , OR 2 or a substituted or unsubstituted (C 1 -C 12 )alkyl group, with the proviso that at least one R 1 is F, Cl, CN or CF 3 ;
each R 2 and R 3 is independently H or a substituted or unsubstituted (C 1 -C 12 )alkyl group;
each R 4 is independently H, F, Cl, Br, I, CN, OH, NO 2 , NH 2 , or a substituted or unsubstituted (C 1 -C 12 )alkyl group;
Z(R 2 ) n is
r is an integer ranging from 2 to 8, inclusive;
each R 25 is independently selected from the group consisting of H, CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , or CH(CH 3 ) 2 ;
said compound having at least one basic group having a pK b of 12 or less or a quaternized nitrogen group.
35 . A method according to claim 34 , wherein
is selected from the group consisting of
36 . A method according to claim 34 , wherein the moiety
which is other than
is selected from the group consisting of
37 . A method according to claim 34 , wherein each R 1 is independently H, F or Cl;
i is 3; two of said moiety
38 . A method according to claim 34 , wherein the compound has the formula:Cited by (0)
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