US2008200549A1PendingUtilityA1

Pharmaceutical composition of ibuprofen and paracetamol and methods of using the same

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Assignee: AFT PHARMACEUTICALS LTDPriority: Jul 7, 2004Filed: Apr 30, 2008Published: Aug 21, 2008
Est. expiryJul 7, 2024(expired)· nominal 20-yr term from priority
Inventors:Hartley Campbell Atkinson
A61P 25/04A61P 29/00A61K 9/2059A61K 31/215A61K 31/16A61K 31/167A61K 31/192A61K 31/44A61K 31/216A61K 31/165A61K 31/19
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Claims

Abstract

A combination pharmaceutical composition for the treatment of pain comprising between about 125 mg and about 150 mg ibuprofen and between about 475 mg and about 500 mg paracetamol, and a method for alleviating pain in a patient comprising administering to the patient a pharmaceutical composition comprising between about 125 mg and about 150 mg ibuprofen and between about 475 mg and about 500 mg paracetamol.

Claims

exact text as granted — not AI-modified
1 . A pharmaceutical composition for the treatment of pain comprising an excipient; ibuprofen, ibuprofen salt, ibuprofen ester, or ibuprofen complex; and paracetamol, paracetamol salt, paracetamol ester, or paracetamol complex; wherein a weight ratio of paracetamol, paracetamol salt, paracetamol ester, or paracetamol complex to ibuprofen, ibuprofen salt, ibuprofen ester, or ibuprofen complex is between about 3 to 1 and about 4 to 1. 
     
     
         2 . The composition of  claim 1  provided in a unit dose formulation comprising between about 125 mg and about 150 mg ibuprofen; and between about 475 mg and about 500 mg paracetamol. 
     
     
         3 . The composition of  claim 1  provided in a unit dose formulation comprising between about 62.5 mg and about 75 mg ibuprofen; and between about 237.5 mg and about 250 mg paracetamol. 
     
     
         4 . The composition of  claim 1  wherein the weight ratio of paracetamol to ibuprofen is about 10 to 3. 
     
     
         5 . The composition of  claim 1  provided in a formulation comprising about 150 mg ibuprofen and about 500 mg paracetamol. 
     
     
         6 . The composition of  claim 1  wherein the ibuprofen is present as a salt, an ester or a complex in an amount sufficient to deliver between about 125 mg and about 150 mg ibuprofen. 
     
     
         7 . The composition of  claim 2  wherein the composition is provided in a formulation suitable to be administered as two unit doses four times a day. 
     
     
         8 . The combination composition of  claim 1  wherein the composition is provided in a formulation suitable to be administered as two unit doses four times a day, and the unit doses are tablets or capsules. 
     
     
         9 . A pharmaceutical composition for the treatment of pain comprising an excipient, ibuprofen, and paracetamol, wherein a synergistically effective weight ratio range of paracetamol to ibuprofen is between about 3.4 to 1 and about 3.3 to 1. 
     
     
         10 . The composition of  claim 9  provided in a unit dose formulation comprising between about 125 mg and about 150 mg ibuprofen; and between about 475 mg and about 500 mg paracetamol. 
     
     
         11 . The composition of  claim 9  provided in a unit dose formulation comprising between about 62.5 mg and about 75 mg ibuprofen; and between about 237.5 mg and about 250 mg paracetamol. 
     
     
         12 . The composition of  claim 9  wherein the weight ratio of paracetamol to ibuprofen is about 10 to 3. 
     
     
         13 . The composition of  claim 9  provided in a unit dose formulation comprising about 150 mg ibuprofen and about 500 mg paracetamol. 
     
     
         14 . The composition of  claim 9  wherein the composition is provided in a formulation suitable to be administered as two unit doses four times a day. 
     
     
         15 . The composition of  claim 9  wherein the composition is provided in a formulation suitable to be administered as two unit doses four times a day, and the unit doses are tablets or capsules. 
     
     
         16 . A method for alleviating pain in a patient comprising administering to said patient the composition of  claim 3 . 
     
     
         17 . The method of  claim 16 , wherein the unit dose is a tablet or a capsule and two unit doses are administered four times daily. 
     
     
         18 . The method of  claim 16  wherein the ratio of paracetamol to ibuprofen in the single therapeutic dose is about 10:3. 
     
     
         19 . The method of  claim 16  comprising administering to said patient 150 mg ibuprofen and 500 mg paracetamol per each administration. 
     
     
         20 . The method of  claim 16  comprising administering to said patient between about 250 mg and about 300 mg ibuprofen and between about 975 mg and about 1000 mg paracetamol, in a single administration.

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