Novel burn treatment composition

Abstract

The invention is directed to a novel topical burn treatment compositions comprising a silicone containing compound, a Vitamin E compound and a local anesthetic. and their use in treating topical burns.

1 . A topical composition comprising (a) a Vitamin E compound; (b) a silicone compound and (b) one or more anesthetics selected from the group consisting of esters, amides and ethers. 
     
     
         2 . The composition according to  claim 1 , wherein the silicone compound is selected from the group consisting of dimethicone and cyclopentasiloxane polysilicone-11. 
     
     
         3 . The composition according to  claim 1 , wherein said anesthetic is lidocaine. 
     
     
         4 . The composition according to  claim 1 , which further comprises a surfactant, a more chelating agent, a bisabolol, a dispersing agent, an emulsifier, an emollient, a pH stabilizing agent and/or a biological additive. 
     
     
         5 . The topical composition according to  claim 1 , which further comprises a biological additive. 
     
     
         6 . The composition according to  claim 8 , wherein said biological additive is selected from the group consisting of aloe,  Arnica, Chamomila  and  Calendula.    
     
     
         7 . The composition according to  claim 1  wherein said composition comprises 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   substance 
                   % By Weight 
                 
                     
                     
                 
                     
                   Silicone compound 
                    0.1-10% 
                 
                     
                   Vitamin E compound 
                    .05-5% 
                 
                     
                   Anesthetic 
                    0.5-10% 
                 
                     
                   Biological additive(s) 
                   0.01-10  
                 
                     
                   Emulsifier(s) 
                    0.1-15 
                 
                     
                   Emollient(s) 
                    0.5-25 
                 
                     
                   Chelator 
                   0.02-2.0 
                 
                     
                   Dispersing agent 
                   0.05-5.0 
                 
                     
                   bisabolol 
                   0.0001-1.0  
                 
                     
                   Polyol 
                    0.1-10% 
                 
                     
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         8 . A topical aqueous composition comprising a Vitamin E compound, an anesthetic selected from the group consisting of esters, amides and ethers, a silicone compound, a surfactant, a chelating agent, a bisabolol, a dispersing agent, an emulsifier, one or more emollients, a pH stabilizing agent and a biological additive. 
     
     
         9 . A method for obtaining the composition according to  claim 8  comprising
 (a) combining an polyol with a chelating agent, dispersing agent in water to obtain a first mixture;   (b) combining an emollient, emulsifier, a silicone compound, and Vitamin E compound to obtain a second mixture;   (c) adding the second mixture obtained in step (b) to the first mixture obtained in step (a) to obtain a third mixture;   (d) providing an aqueous solution of an anesthetic;   (e) adding the anesthetic of step (d) to the third mixture obtained in step (c) to obtain a fourth mixture;   (f) adding a biological additive and surfactant to the fourth mixture obtained in step   (e) and   (g) stabilizing the pH of the mixture obtained in step (f) to obtain said composition.   
     
     
         10 . A method for obtaining the composition of  claim 1 , comprising combining a silicone compound and Vitamin E compound in an oleophilic phase to obtain a first mixture and adding an aqueous solution of an anesthetic to said first mixture to obtain said composition. 
     
     
         11 . (canceled) 
     
     
         12 . A method for obtaining the composition according to  claim 11  comprising combining a silicone compound and Vitamin E compound in an oleophilic phase to obtain a first mixture and adding an aqueous solution of an anesthetic to said first mixture to obtain a third mixture and adding  Arnica  to said third mixture to obtain said composition. 
     
     
         13 . A method for treating a burn in a subject in need thereof comprising topically administering to a subject in need thereof an amount of the composition according to  claim 1 . 
     
     
         14 . (canceled) 
     
     
         15 . A composition comprising  arnica  or  chamomilla , a silicone compound, a Vitamin E compound and an anesthetic selected from the group consisting of esters, amides and ethers. 
     
     
         16 . (canceled)