Topical Compositions

Abstract

The present invention provides new topical pharmaceutical or cosmetic compositions for the prevention and treatment of irritation of mucous cells, or skin cells, comprising a combination of: xylitol, myoinositol or mannitol or any combination of these; glycerol and/or urea; water; in the absence of any oil in water or wax in water emulsion.

1 - 18 . (canceled) 
     
     
         19 . A topical pharmaceutical or cosmetic composition free of any oil-in-water or wax-in-water emulsions for the prevention and treatment of irritation of mucous cells, or skin cells, comprising a combination of: (a) xylitol, myoinositol or mannitol or any combination of these; (b) glycerol and/or urea; (c) water; and (d) less than 0.01% inorganic salts. 
     
     
         20 . A topical pharmaceutical or cosmetic composition free of any oil-in-water or wax-in-water emulsions for the prevention and treatment of irritation of mucous cells according to  claim 19 , comprising a combination of: a) 1.5-5.5% xylitol, myoinositol or mannitol or any combination of these; b) 0.9-2.0% glycerol; c) less than 0.01% inorganic salts; and d) water. 
     
     
         21 . A topical pharmaceutical or cosmetic composition according to  claim 20 , comprising 1.5-3.0% xylitol and 0.9-1.8% glycerol. 
     
     
         22 . A topical pharmaceutical or cosmetic composition according to  claim 20 , comprising 1.8-3.6% myoinositol and 0.9-1.8% glycerol. 
     
     
         23 . A topical pharmaceutical or cosmetic composition according to  claim 20 , comprising 1.8-3.6% mannitol and 0.9-1.8% glycerol. 
     
     
         24 . A topical pharmaceutical or cosmetic composition according to  claim 20 , comprising 1-2% xylitol, 1.5-3% mannitol and 0.9-1.8% glycerol. 
     
     
         25 . A topical pharmaceutical or cosmetic composition according to  claim 19 , useful for preventing and treating irritation of the mucous membranes caused by allergies, chemical pollutants, or physical irritants, manifested by redness, tearing, burning, discomfort or itching. 
     
     
         26 . A topical pharmaceutical or cosmetic composition according to  claim 19 , Further comprising at least one viscosity enhancing agent. 
     
     
         27 . A topical pharmaceutical or cosmetic composition according to  claim 19 , further comprising at least one pharmaceutically active agent in suspension. 
     
     
         28 . A topical pharmaceutical or cosmetic composition according to  claim 19 , further comprising at least one pharmaceutically active agent in solution. 
     
     
         29 . A topical pharmaceutical or cosmetic composition according to  claim 19 , further comprising pharmaceutically acceptable excipients, additives or preservatives. 
     
     
         30 . A topical pharmaceutical or cosmetic composition according to  claim 19 , useful for the prevention and alleviation of cell damage caused by preservatives, detergents or drugs, used in topical pharmaceutical cosmetic or veterinary compositions. 
     
     
         31 . A topical pharmaceutical or cosmetic composition according to  claim 19 , further comprising an agent, to lower the surface tension of the solution to less than 90% of that of water. 
     
     
         32 . A topical pharmaceutical or cosmetic composition free of any oil-in-water or wax-in-water emulsions, for the prevention and treatment of irritation of skin cells, comprising a combination of a) 5-18% xylitol, myoinositol or mannitol or any combination of these; b) 2.5-10% glycerol and/or urea; c) water; (d) less than 0.01% inorganic salts. 
     
     
         33 . A topical pharmaceutical or cosmetic composition according to  claim 32 , comprising 5-18% xylitol and 5-10% urea. 
     
     
         34 . A topical pharmaceutical or cosmetic composition according to  claim 32 , comprising 5-18% myoinositol and 5-10% urea. 
     
     
         35 . A topical pharmaceutical or cosmetic composition according to  claim 32 , comprising 5-18% mannitol and 5-10% urea. 
     
     
         36 . A topical pharmaceutical or cosmetic composition according to  claim 32 , further comprising an agent, to lower the surface tension of the solution to less than 90% of that of water. 
     
     
         37 . A topical pharmaceutical or cosmetic composition according to  claim 32 , useful for the prevention and alleviation of cell damage caused by preservatives, detergents or drugs, used in topical pharmaceutical cosmetic or veterinary compositions. 
     
     
         38 . A topical pharmaceutical or cosmetic composition according to  claim 32 , further comprising pharmaceutically acceptable excipients, additives or preservatives. 
     
     
         39 . A topical pharmaceutical or cosmetic composition according to  claim 32 , further comprising at least one pharmaceutically active agent in solution. 
     
     
         40 . A topical pharmaceutical or cosmetic composition according to  claim 32 , further comprising at least one pharmaceutically active agent in suspension. 
     
     
         41 . A topical pharmaceutical or cosmetic composition according to  claim 32 , further comprising at least one viscosity enhancing agent. 
     
     
         42 . A topical pharmaceutical or cosmetic composition according to  claim 32 , useful for preventing and treating irritation of the mucous membranes of the eye caused by allergies, chemical pollutants, or physical irritants, manifested by redness, tearing, burning, discomfort or itching. 
     
     
         43 . A method for treating irritation of mucous cells, or skin cells, comprising steps of (i) admixing (a) xylitol, myoinositol or mannitol or any combination of these; (b) glycerol and/or urea; (c) water; and (d) less than 0.01% inorganic salts; and (ii) administering said admixture on top of said mucous cells, or skin cells, until irritation is treated.