Automated Method for Detecting Cancers and High Grade Hyperplasias

Abstract

Automated methods for detecting cancer and related hyperplasias in biological samples.

1 . A computer-usable medium having computer readable instructions stored thereon for execution by a processor to perform an automated analysis method of a biological sample comprising cell nuclei from said subject with one or more distinguishable labeled probes directed to at least one chromosomal sequence that characterizes the abnormality under conditions that promote hybridization of the one or more probes to the at least one sequence, the method comprising the steps of
 obtaining a representation of the one or more distinguishable labels hybridized to the chromosomal sequences;   analyzing the distribution and intensity of binding of the one or more labels in the representation to determine the presence and/or extent of an abnormal chromosomal component; and   reporting results of the analysis.