Modulation of pathogenicity

Abstract

The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R 1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R 2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A 1 and A 2 each independently represent an optionally substituted C 1 -C 20 -alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR 4 , CO, CO 2 , CS, SO or SO 2 X is selected from the group consisting of S, O, N, NR 4 , SO or SO 2 ;

1 . A compound 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or physiologically acceptable derivative thereof. 
     
     
         2 . A method for inhibiting the production of a virulence factor comprising contact with a compound of  claim 1 . 
     
     
         3 . The method of  claim 2  for the treatment or prevention of bacterial damage or disease. 
     
     
         4 . The method of  claim 3  wherein the bacteria is  Pseudomonas aeruginosa  or  Burkholderia cepacia.    
     
     
         5 . A composition for inhibiting biofilm formation comprising a compound of  claim 1 .