Human cytokine receptor

Abstract

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”

1 . A heterodimeric receptor complex comprising an isolated soluble cytokine receptor polypeptide,
 wherein the isolated soluble cytokine receptor polypeptide comprises amino acid residues 28 to 231 of SEQ ID NO:2, and   wherein the soluble cytokine receptor polypeptide binds IL-TIF (SEQ ID NO:15) or antagonizes IL-TIF activity, and   further comprising a soluble zcytor11 polypeptide.   
     
     
         2 . An isolated polypeptide according to  claim 1 , wherein the heterodimeric receptor complex further comprises an affinity tag, chemical moiety, toxin, or label. 
     
     
         3 . A heterodimeric receptor complex comprising an isolated soluble cytokine receptor polypeptide comprising amino acid residues 28 to 231 of SEQ ID NO:2, and a soluble zcytor11 polypeptide. 
     
     
         4 . An isolated heterodimeric soluble receptor complex comprising a first soluble cytokine receptor polypeptide and a second soluble cytokine receptor polypeptide, wherein the first soluble cytokine receptor polypeptide comprises amino acid residues 28 to 231 of SEQ ID NO:2, and wherein the second soluble cytokine receptor polypeptide comprises a soluble zcytor11 receptor polypeptide.