Pyrroloquinoline quinone drugs for treatement of cardiac injury and methods of use thereof

Abstract

The invention includes compositions comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a composition of the invention with a human patient.

1 . A method of preventing organ damage during organ or tissue transplantation, the method comprising administering to an organ donor pyrroloquinoline quinone prior to or concurrent with removal of said organ, such that damage caused by reperfusion of said organ or tissue is decreased or prevented. 
     
     
         2 . The method of  claim 1 , wherein said organ is the heart. 
     
     
         3 . The method of  claim 1 , wherein said organ is the kidney. 
     
     
         4 . A method of preventing organ damage during organ or tissue transplantation, the method comprising contacting pyrroloquinoline quinone with one or more organs or tissues, such that damage caused by reperfusion of said organ or tissue is decreased or prevented. 
     
     
         5 . A method of preventing organ damage during an ischemic insult, the method comprising administering to a subject in need thereof, an effective amount of pyrroloquinoline quinone prior to or during said ischemic insult, such that damage to an organ is decreased or prevented. 
     
     
         6 . The method of  claim 5 , wherein said organ is the heart. 
     
     
         7 . The method of  claim 5 , wherein said organ is the kidney. 
     
     
         8 . The method of  claim 5 , wherein said pyrroloquinoline quinone is administered at a concentration of between 1 mg/ml and 10 mg/ml.