Non-nuclear effects of thyroid hormone

Abstract

Truncated thyroid hormone receptors ΔTRα1 and ΔTRα2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of ΔTRα1 and ΔTRα2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.

1 - 21 . (canceled) 
     
     
         22 . A method of treating a subject who has a neurologic disorder, the method comprising administering to the subject a therapeutically effective amount of a ΔTRα2 ligand. 
     
     
         23 . A method of treating an individual who has a mood disorder, the method comprising administering to the individual a therapeutically effective amount of a ΔTRα2 ligand. 
     
     
         24 - 45 . (canceled) 
     
     
         46 . The method of  claim 22 , wherein the disorder is selected from the group consisting of bipolar disorder, major depression, attention deficit disorder, attention deficit hyperactivity disorder, and obsessive-compulsive disorder. 
     
     
         47 . The method of  claim 23 , wherein the disorder is depression. 
     
     
         48 . The method of  claim 23 , wherein the disorder is postpartum depression. 
     
     
         49 . The method of  claim 22 , wherein the ΔTRα2 ligand is a flavone. 
     
     
         50 . The method of  claim 23 , wherein the ΔTRα2 ligand is a flavone. 
     
     
         51 . The method of  claim 22 , wherein the ΔTRα2 ligand is an aurone. 
     
     
         52 . The method of  claim 23 , wherein the ΔTRα2 ligand is an aurone