Process for the preparation of ferutinine from ferula genus plants

Abstract

The invention relates to a process for the preparation of ferutinine (Ia) from Ferula spp extracts comprising basic hydrolysis of the extracts and treatment with p-pivaloyloxybenzoic acid. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatological field.

1 . A method of preparing a cosmetic or dermatological composition, comprising:
 adding an effective amount of  Ferula  spp extract to an acceptable excipient for a cosmetic or dermatological composition.   
     
     
         2 . The method according to  claim 1 , wherein the acceptable excipient is selected from the group consisting of soy lecithin, phospholipids, lauroylphosphatidylcoline and myristoylphosphatidilcoline. 
     
     
         3 . The method according to  claim 1 , further comprising:
 incorporating the  Ferula  spp extract and excipient into one of an emulsion and a transdermal plaster.   
     
     
         4 . The method according to  claim 1 , wherein the cosmetic or dermatological composition is in a form selected from the group consisting of creams, gels and lotions. 
     
     
         5 . The method according to  claim 1 , wherein the  Ferula  spp extract is a  Ferula hermonis  extract. 
     
     
         6 . The method according to  claim 1 , wherein the  Ferula  spp extract is a  Ferula communis  extract. 
     
     
         7 . A method of preparing a cosmetic or dermatological composition, comprising:
 adding an effective amount of p-pivaloyloxyferutinine to an acceptable excipient for a cosmetic or dermatological composition.   
     
     
         8 . The method according to  claim 7 , wherein the acceptable excipient is selected from the group consisting of soy lecithin, phospholipids, lauroylphosphatidylcoline and myristoylphosphatidilcoline. 
     
     
         9 . The method according to  claim 7 , further comprising:
 incorporating the p-pivaloyloxyferutinine and excipient into one of an emulsion and a transdermal plaster.   
     
     
         10 . The method according to  claim 7 , wherein the cosmetic or dermatological composition is in a form selected from the group consisting of creams, gels and lotions.