Antimicrobial and Antinflammatory Composition

Abstract

The invention relates to the use of at least davanone and 1,8-cineol for the manufacture of an antimicrobial and/or antiinflammatory composition as well as a method of producing said composition.

1 . Use of at least davanone and 1,8-cineol for the manufacture of an antimicrobial and/or antiinflammatory composition. 
     
     
         2 . Use according to the  claim 1 , wherein said composition comprises favonols. 
     
     
         3 . Use according to the  claims 1  or  2 , wherein said davanone, 1,8-cineol and flavonols are isolated from one or more plants. 
     
     
         4 . Use according to any of the preceding claims, wherein said composition comprising from about 0.0025 to about 1.0% (w/v) of said davanone and 1,8-cineol and from about 0.1 to about 100 ug/ml of said flavonol. 
     
     
         5 . Use according to any of the preceding claims wherein said flavonol is selected from the group comprising casticin, centaureidin, quercetin 3.4-dimethyl ether and quercetin 3.7-dimethyl ether. 
     
     
         6 . Use according to any of the preceding claims, wherein the flavonols are casticin, centaureidin, quercetin 3.4-dimethyl ether and quercetin 3.7-dimethyl ether. 
     
     
         7 . Use according to  claim 6 , wherein the said composition comprises from about 0.4 ug/ml to about 400 ug/ml of casticin, centaureidin, quercetin 3.4-dimethyl ether and quercetin 3.7-dimethyl ether. 
     
     
         8 . Use according to any of the  claims 6 - 7 , wherein the flavonols are present in an amount of from about 0.1 to about 100 ug/ml of casticin, from about 0.1 to about 100 ug/ml of centaureidin, from about 0.1 to about 100 ug/ml of quercetin 3.4-dimethyl ether and from about 0.1 to about 100 ug/ml of quercetin 3.7-dimethyl ether. 
     
     
         9 . Use according to any of preceding claims, wherein said davanone, 1,8-cineol and flavonols are obtained from one or more plants selected from the group comprising  A. oelandicum, A. dracunculus, A. campestris, A. vulgaris, A. absinthium, A. stelleriana, A. rupestris, A. abrotanuin, A. pallens, A. lerchiana, A. thuscula, A. rehan, A. persica, A. glabella, Lantana camara  and  Tanacetum vulgare.    
     
     
         10 . Use according to any of the preceding claims, wherein said composition is a tablet, capsule, granules, cream, gel, dermal or mucosal patch, sachet or wafers or shampoo. 
     
     
         11 . Use according to any of the preceding claims, wherein the composition is a pharmaceutical composition. 
     
     
         12 . A method of extracting antimicrobial and/or anti-inflammatory components from one or more plants comprising the steps of;
 a) providing at least one plant material,   b) processing said plant material by distillation and obtaining a water and an oil part, wherein said water part comprises the green plant material and   c) obtaining an oil part comprising at least davanone and/or 1,8-cineol   
     
     
         13 . The method according to  claim 12 , wherein said method comprises an additional step d) of heating said water phase obtained in step b) and obtaining free flavonols. 
     
     
         14 . The method according to any of the  claims 12 - 13 , wherein said method comprises an additional step e) of drying the green plant material. 
     
     
         15 . The method according to any of the  claims 12 - 14 , wherein said method comprises an additional step f) of extracting said flavonols from said green plant material. 
     
     
         16 . The method according to any of the  claims 12 - 15 , wherein said method comprises an additional step g) of mixing said oil part obtained in step c) with said flavonols obtained in step f). 
     
     
         17 . A method of treating a mammal suffering from an antimicrobial disease or an inflammatory disease by the use of the composition according to any of the  claims 1 - 11 .