Antiangiogenic active immunotherapy

Abstract

Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis. These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.

1 .- 33 . (canceled) 
     
     
         34 . An immunogenic composition comprising a fusion protein containing a VEGFR2 or fragments thereof and a mutant of VEGF, administered in the presence of or incorporated into  Neisseria meningitidis  outer membrane derived VSSP. 
     
     
         35 .- 79 . (canceled)