Composition for Oral Cavity

Abstract

The present invention relates to an oral care composition, which contains a compound represented by the formula (A): (wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30); and a coaggregation inhibitor of bacteria of the genus Fusobacterium and cariogenic bacteria, which contains the compound as an effective ingredient. The composition for oral cavity according to the present invention inhibits coaggregation of bacteria of the genus Fusobacterium with cariogenic bacteria so that it has an excellent caries preventive effect.

1 . An oral care composition, comprising a compound represented by the following formula (A): 
       
         
           
           
               
               
           
         
       
       wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, E represents a hydrogen atom or a methyl group, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30. 
     
     
         2 . An oral care composition, comprising a compound represented by the following formula (B): 
       [Chemical Formula 2]
   ROCH 2 CH 2  m OG) n   (B) 
 
       wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30. 
     
     
         3 . An oral care composition, comprising a compound represented by the following formula (C): 
       
         
           
           
               
               
           
         
       
       wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, E represents a hydrogen atom or a methyl group, x stands for the number of from 0 to 200 and y stands for the number of from 1 to 30. 
     
     
         4 . The oral care composition according to any one of  claims 1  to  3 , further comprising a sugar alcohol having from 4 to 12 carbon atoms. 
     
     
         5 . A coaggregation inhibitor of bacteria of the genus  Fusobacterium  and cariogenic bacteria, comprising, as an effective ingredient, a compound represented by the following formula (A): 
       
         
           
           
               
               
           
         
       
       wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, E represents a hydrogen atom or a methyl group, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30. 
     
     
         6 . Use, for the preparation of a coaggregation inhibitor of bacteria of the genus  Fusobacterium  and cariogenic bacteria, of a compound represented by the following formula (A): 
       
         
           
           
               
               
           
         
       
       wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, E represents a hydrogen atom or a methyl group, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30. 
     
     
         7 . A method for inhibiting the coaggregation of genus  Fusobacterium  and cariogenic bacteria, comprising the step of applying, into the oral cavity, an effective amount of a compound represented by the following formula (A): 
       
         
           
           
               
               
           
         
       
       wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, E represents a hydrogen atom or a methyl group, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30.