Hemostat

Abstract

The present invention is directed towards a hemostat comprising an absorbable foam, an absorbable woven or knitted fabric, thrombin and/or fibrinogen.

1 . A hemostat comprising an absorbable foam, an absorbable woven or knitted fabric, thrombin and fibrinogen. 
     
     
         2 . The hemostat of  claim 1 , where the foam comprises one or more polymers selected from the group consisting of polysaccharides, albumin, chitin, carboxymethyl chitin, hyaluronic acid, salts of hyaluronic acid, alginate, alginic acid, propylene glycol alginate, glycogen, dextran, dextran sulfate, curdlan, pectin, pullulan, xanthan, chondroitin, chondroitin sulfates, carboxymethyl dextran, carboxymethyl chitosan, chitosan, heparin, heparin sulfate, heparan, heparan sulfate, dermatan sulfate, keratan sulfate, carrageenans, chitosan, starch, amylose, amylopectin, poly-N-glucosamine, polymannuronic acid, polyglucuronic acid polyguluronic acid, and derivatives of any of the above. 
     
     
         3 . The hemostat of  claim 2 , where the foam comprises a polysaccharide selected from the group consisting of methylcellulose, alkylhydroxyalkyl cellulose, hydroxyalkyl cellulose, cellulose sulfate, salts of carboxymethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose. 
     
     
         4 . The hemostat of  claim 3 , where the absorbable woven or knitted fabric comprises oxidized polysaccharides. 
     
     
         5 . The hemostat of  claim 4 , where the absorbable woven or knitted fabric comprises oxidized cellulose. 
     
     
         6 . The hemostat of  claim 5 , where the absorbable woven or knitted fabric comprises oxidized regenerated cellulose. 
     
     
         7 . The hemostat of  claim 5 , where the absorbable woven or knitted fabric is an absorbable knitted fabric comprising oxidized regenerated cellulose. 
     
     
         8 . The hemostat of  claim 1 , where the foam comprises carboxymethyl cellulose and albumin, the absorbable woven or knitted fabric comprises oxidized regenerated cellulose, and the thrombin and fibrinogen are incorporated into or sprayed onto the foam. 
     
     
         9 . The hemostat of  claim 8 , where the weight ratio of carboxymethyl cellulose to the albumin ranges from about 1:8 to 8:1 by weight. 
     
     
         10 . The hemostat of  claim 8 , wherein the thrombin activity on the hemostat ranges from about 20 to 500 IU/cm 2 , and the fibrinogen activity ranges from about 2 to 15 mg/cm 2 .