Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment

Abstract

Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.

1 . Percutaneously absorbable preparations having a base of water-soluble and biologically soluble polymer material, and an active substance held in the base, comprising:
 having a slender, pointed shape, such as a needle-like or filamentous shape, adapted for insertion into skin to percutaneously administer the active substance into the body, wherein the polymer material is at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids   
     
     
         2 .- 28 . (canceled) 
     
     
         29 . The percutaneously absorbable preparations of  claim 1 , wherein the protein is at least one material selected from the group consisting of serum albumin, serum α-acid glycoprotein and gelatin. 
     
     
         30 . The percutaneously absorbable preparations of  claim 1 , wherein the polysaccharide is at least one material selected from the group consisting of glycogen, dextrin, dextran, dextran sulfate, sodium chondroitin sulfate, hydroxy propyl cellulose, alginic acid, agarose, chitin, chitosan, pullulan and hyaluronic acid. 
     
     
         31 . The percutaneously absorbable preparations of  claim 1 , wherein the base contains an absorption rate controller for controlling the absorption rate of the active substance. 
     
     
         32 . The percutaneously absorbable preparations of  claim 31 , wherein the absorption rate controller is an absorption enhancer. 
     
     
         33 . The percutaneously absorbable preparations of  claim 32 , wherein the absorption enhancer is a surfactant. 
     
     
         34 . The percutaneously absorbable preparations of  claim 1 , wherein the active substance is a drug. 
     
     
         35 . The percutaneously absorbable preparations of  claim 34 , wherein the drug falls in peptides, proteins, nucleic acids, polysaccharides or vaccine. 
     
     
         36 . The percutaneously absorbable preparations of  claim 1 , wherein the base contains a stabilizer for stabilizing the active substance. 
     
     
         37 . The percutaneously absorbable preparations of  claim 1 , further comprising a moisture-proof layer formed on the surface thereof. 
     
     
         38 . The percutaneously absorbable preparations of  claim 1 , wherein the preparations are constricted or have a secant in part on the surface thereof. 
     
     
         39 . The percutaneously absorbable preparations of  claim 1 , wherein the preparations comprise at least two of them linked in series. 
     
     
         40 . Percutaneously absorbable preparations having a base of water-soluble and biologically soluble polymer material, and an active substance held in the base, comprising:
 having a slender, pointed shape, such as a needle-like or filamentous shape, adapted for insertion into skin to percutaneously administer the active substance into the body, wherein the percutaneously absorbable preparations have a water-insoluble layer formed on the surface thereof, and wherein the active substance is released in a sustained-release fashion.   
     
     
         41 . The percutaneously absorbable preparations of  claim 40 , wherein the water-insoluble layer is formed by a cross-link reaction. 
     
     
         42 . The percutaneously absorbable preparations of  claim 40 , wherein the polymer material is at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. 
     
     
         43 . The percutaneously absorbable preparations of  claim 40 , wherein the preparations comprise at least two of them linked in series. 
     
     
         44 . Percutaneously absorbable preparations having a base of water-soluble and biologically soluble polymer material, and an active substance held in the base, comprising:
 having a slender, pointed shape, such as a needle-like or filamentous shape, adapted for insertion into skin to percutaneously administer the active substance into the body, wherein the base contains a porous compound, and wherein the active substance is held in the porous compound and is released in a sustained-release fashion.   
     
     
         45 . The percutaneously absorbable preparations of  claim 44 , wherein the porous material is at least one material selected from the group consisting of calcium silicate, aluminum silicate, magnesium silicate, anhydrous silicate, porous calcium carbonate, porous calcium phosphate and porous silicon. 
     
     
         46 . The percutaneously absorbable preparations of  claim 44 , wherein the preparations comprise at least two of them linked in series. 
     
     
         47 . Percutaneously absorbable preparations having a base of water-soluble and biologically soluble polymer material, and an active substance held in the base, comprising:
 having a slender, pointed shape, such as a needle-like or filamentous shape, adapted for insertion into skin to percutaneously administer the active substance into the body, wherein the active substance is a long-acting material and is released in a sustained-release fashion.   
     
     
         48 . The percutaneously absorbable preparations of  claim 47 , wherein the long-acting substance is long-acting type insulin or protein cross-linked with polyethylene glycol. 
     
     
         49 . The percutaneously absorbable preparations of  claim 47 , wherein the preparations comprise at least two of them linked in series. 
     
     
         50 . A sheet-like carrier for holding at least one of the percutaneously absorbable preparations of  claim 1  on at least one of the surfaces thereof, wherein the preparations held on the carrier are inserted into the skin by pushing the carrier thereonto. 
     
     
         51 . A sheet-like carrier for holding at least one of the percutaneously absorbable preparations of  claim 40  on at least one of the surfaces thereof, wherein the preparations held on the carrier are inserted into the skin by pushing the carrier thereonto. 
     
     
         52 . A sheet-like carrier for holding at least one of the percutaneously absorbable preparations of  claim 44  on at least one of the surfaces thereof, wherein the preparations held on the carrier are inserted into the skin by pushing the carrier thereonto. 
     
     
         53 . A sheet-like carrier for holding at least one of the percutaneously absorbable preparations of  claim 47  on at least one of the surfaces thereof, wherein the preparations held on the carrier are inserted into the skin by pushing the carrier thereonto. 
     
     
         54 . Equipment for holding percutaneously absorbable preparations comprising having a base of water-soluble and biologically soluble polymer material, an active substance held in the base, and having a slender, pointed shape, such as a needle-like or filamentous shape, adapted for insertion into skin to percutaneously administer the active substance into the body, the equipment comprising a main body having a penetration hole in and along which the preparations are moved. 
     
     
         55 . Equipment for holding percutaneously absorbable preparations, the equipment comprising a main body having a penetration hole in and along which the preparations are moved, wherein the preparations fall in  claim 1 . 
     
     
         56 . Equipment for holding percutaneously absorbable preparations, the equipment comprising a main body having a penetration hole in and along which the preparations are moved, wherein the preparations fall in  claim 40 . 
     
     
         57 . Equipment for holding percutaneously absorbable preparations, the equipment comprising a main body having a penetration hole in and along which the preparations are moved, wherein the preparations fall in  claim 44 . 
     
     
         58 . Equipment for holding percutaneously absorbable preparations, the equipment comprising a main body having a penetration hole in and along which the preparations are moved, wherein the preparations fall in  claim 47 . 
     
     
         59 . The equipment of  claim 54 , wherein the penetration hole accommodates a spacer kept in contact with the preparations held in the penetration hole, so that the spacer moves in and along the penetration hole while being kept in contact with the preparations. 
     
     
         60 . The equipment of  claim 54 , wherein the main body comprises a concave to which the penetration hole is open. 
     
     
         61 . The equipment of  claim 60 , wherein the concave comprises female threads cut on the inside wall thereof. 
     
     
         62 . The equipment of  claim 54 , wherein the main body is made of plastics.