FGF-5 Supported and Binding Peptides

Abstract

The present invention provides peptides and supported peptides that bind to FGF-5.

1 . A composition comprising at least one peptide selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, and 14, wherein said peptide binds to a fibroblast growth factor. 
     
     
         2 . The composition of  claim 1 , wherein said peptide is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOS:1, 3, 5, 7, 9, 11, and 13. 
     
     
         3 . The composition of  claim 1 , wherein said peptide is expressed in a protease resistant scaffold. 
     
     
         4 . The composition of  claim 3 , wherein said scaffold is a protease inhibitor. 
     
     
         5 . The composition of  claim 4 , wherein said protease inhibitor is selected from the group consisting of Bowman-Birk Inhibitor, soybean trypsin inhibitor, and Eglin chymotrypsin inhibitor. 
     
     
         6 . The composition of  claim 3 , wherein said protease resistant scaffold and said peptide comprise a fusion protein. 
     
     
         7 . A cosmetic or pharmaceutical composition comprising said at least one peptide of  claim 1 . 
     
     
         8 . The composition of  claim 7 , wherein said composition is capable of modulating hair growth. 
     
     
         9 . The composition of  claim 7 , wherein said composition further comprises a scaffold. 
     
     
         10 . A method for modulating hair growth comprising:
 i) providing a composition comprising a peptide contained within a scaffold;   ii) providing a subject to be treated; and   iii) applying said composition to said subject in an area in which hair growth modulation is desired.   
     
     
         11 . The method of  claim 10 , wherein said peptide binds to a fibroblast growth factor. 
     
     
         12 . The method of  claim 11 , wherein said fibroblast growth factor (FGF) is FGF-5. 
     
     
         13 . The method of  claim 10 , wherein said scaffold is selected from the group consisting of Bowman-Birk inhibitor, soybean trypsin inhibitor, and Eglin chymotrypsin inhibitor. 
     
     
         14 . The method of  claim 10 , wherein said peptide is selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, and 14. 
     
     
         15 . The method of  claim 10 , wherein said peptide is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, and 13. 
     
     
         16 . A method for decreasing the activity of a fibroblast growth factor comprising the steps of:
 i) providing a subject; and   ii) administering the composition of  claim 1  to said subject, under conditions such that the activity of said fibroblast growth factor is decreased.   
     
     
         17 . The method of  claim 16 , wherein said fibroblast growth factor is FGF-5. 
     
     
         18 . A composition comprising an FGF-5 peptide sequence selected from the group of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 15-43, 45-65, 68-84, 86, 88, 90, 92, 24, 26, 98, and 100.