US2008269196A1PendingUtilityA1
6-Arylalkylamino-2,3,4,5-Tetrahydro-1H-Benzo[D]Azepines as 5-Ht2c Receptor Agonists

Assignee: BRINER KARINPriority: Sep 1, 2005Filed: Sep 1, 2006Published: Oct 30, 2008
Est. expirySep 1, 2025(expired)· nominal 20-yr term from priority
Inventors:Karin Briner Maria Adeva Bartolome Manuel Javier Cases-Thomas Christopher Stanley Galka Alicia Llorente Maria Angeles Martinez-Grau Michael Philip Mazanetz John Cunningham O' Toole Richard Edmund Rathmell Matthew Robert Reinhard Selma Sapmaz Andrew Caerwyn Williams
A61P 43/00A61P 25/28A61P 25/22A61P 25/24A61P 25/02A61P 25/04A61P 25/20A61P 3/04A61P 25/00A61P 25/14A61P 25/16A61P 25/18A61P 3/00A61P 25/30A61P 15/10A61P 15/08C07D 409/12C07D 223/16C07D 413/12C07D 417/14C07D 417/12C07D 401/12C07D 403/12
PatentIndex Score
Cited by
References
Claims
Abstract

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is —NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.
Claims

exact text as granted — not AI-modified
1 . A compound of Formula I: 
       
         
           
           
               
               
           
         
       
       where:
 R 1  is hydrogen; 
 R 2 , R 3 , and R 4  are each hydrogen; 
 R 5  is hydrogen; 
 R 6  is —(C 1 -C 3 )alkyl-S—(C 0 -C 3 )alkyl-R 10 , —(C 1 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-R 11 , or —(C 1 -C 3 )alkyl-O—(C 0 -C 3 )alkyl-R 13 ; 
 R 7  is chloro; 
 R 8  is hydrogen; 
 R 9  is hydrogen; 
 R 10  is
 a) an aromatic heterocycle substituent selected from the group consisting of tetrazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,3-oxadiazolyl, 1,3,4-oxadiazolyl, and 1,2,4-oxadiazolyl, any one of which may optionally be substituted with a substituent selected from the group consisting of (C 1 -C 4 )alkyl optionally substituted with 1 to 5 fluoro substituents, Ph 1 -(C 0 -C 3 )alkyl, Ar 1 —(C 0 -C 3 )alkyl, (C 1 -C 4 )alkyl-C(O)—, Ph 1 -(C 0 -C 3 )alkyl-C(O)—, Ar 1 —(C 0 -C 3 )alkyl-C(O)—, (C 1 -C 4 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the on the and (C 1 -C 4 )alkyl moiety with 1 to 5 fluoro substituents, (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, Ph 1 -(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, Ar 1 —(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl; 
 b) an aromatic heterocycle substituent selected from the group consisting of imidazolyl, thiazolyl, isothiazolyl, thiophenyl, pyrazolyl, oxazolyl, isoxazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, or a heterocycle selected from thiazolinyl, any one of which may be optionally substituted with one to two substituents selected from the group consisting of
 (C 1 -C 6 )alkyl optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 Ar 1 —(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-C(O)—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—, 
 (C 1 -C 6 )alkyl-NH—C(O)— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, and 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 
  or optionally substituted on ring carbon atoms with one or two substituents selected from the group consisting of
 halo, 
 cyano, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkoxy optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkylthio optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkylthio, 
 (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Ar 1 —(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-C(O)—NH—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—, (C 1 -C 6 )alkyl-O—C(O)—NH— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, and 
 Ar 1 —(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 
  or optionally substituted on two adjacent ring atoms with a bivalent 3 to 4 carbon hydrocarbon substituent which, together with the ring atoms to which it is attached, form a benzene ring or a partially saturated five- or six-membered ring; 
 c) phenyl optionally substituted with:
 i) 1 to 5 independently selected halo substituents; or 
 ii) 1 to 3 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , nitro, hydroxy, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; or 
 iii) 0, 1, or 2 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , methyl, —CF 3 , methoxy, —OCF 3 , nitro, and hydroxy, together with one substituent selected from the group consisting of
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 Ph 1 -(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 5 )alkyl, 
 thiazolyl-(C 0 -C 1 )alkyl optionally substituted with a substituent independently selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, and (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl- C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl; 
 
 
 d) an aromatic heterocycle substituent selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, any of which may be optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , methyl, —CF 3 , methoxy, —OCF 3 , nitro, hydroxy, and optionally further substituted with a substituent selected from the group consisting of
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl optionally further substituted on the alkyl moiety with 1 to 6 fluoro substituents and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 Ph 1 -(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 5 )alkyl, 
 thiazolyl-(C 0 -C 1 )alkyl optionally substituted with a substituent independently selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, and (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 5 )alkyl-, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl; or 
 
 e) alpha-naphthalyl, quinolin-2-yl, quinolin-3-yl, or quinolin-4-yl; 
 
 R 11  is
 a) phenyl optionally substituted with:
 i) 1 to 5 independently selected halo substituents; or 
 ii) 1 to 3 substituents independently selected from the group consisting of halo, cyano, methyl, —CF 3 , —SCF 3 , methoxy, nitro, and hydroxy; or 
 iii) 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, methyl, —CF 3 , —SCF 3 , methoxy, nitro, and hydroxy and further substituted with a substituent selected from the group consisting of:
 (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 5 )alkyl-, 
 (C 1 -C 6 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, and 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl; 
 
 
 b) pyridyl optionally substituted with
 i) 1 to 3 substituents independently selected from the group consisting of halo, cyano, methyl, —CF 3 , —SCF 3 , methoxy, nitro, and hydroxy; or 
 ii) 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, methyl, —CF 3 , —SCF 3 , methoxy, nitro, and hydroxy, and further substituted with a substituent selected from the group consisting of:
 (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, and 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl; 
 
 
 c) pyridazinyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, hydroxy, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; and (C 1 -C 6 )alkylthio optionally further substituted with 1 to 6 fluoro substituents; or 
 d) a five-membered aromatic heterocycle selected from the group of thiophenyl, thiazole, isothiazole optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, hydroxy, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkylthio optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkylamino optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkyl-C(O)—; 
 
 R 12  is hydrogen or methyl 
 R 13  is a) phenyl optionally substituted with:
 i) 1 to 5 independently selected halo substituents; or 
 ii) 1 to 3 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , nitro, hydroxy, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; or 
 iii) 0, 1, or 2 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , methyl, —CF 3 , methoxy, —OCF 3 , nitro, and hydroxy, together with one substituent selected from the group consisting of
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 Ph 1 -(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl- C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl; or 
 
 b) thiophenyl optionally substituted with one to two substituents selected from the group consisting of
 halo, 
 cyano, 
 (C 1 -C 6 )alkyl optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 Ar 1 —(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-C(O)—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—, 
 (C 1 -C 6 )alkyl-NH—C(O)— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkoxy optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkylthio optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkylthio, 
 (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Ar 1 —(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-C(O)—NH—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—, 
 (C 1 -C 6 )alkyl-O—C(O)—NH— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, and 
 Ar 1 —(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents; 
 
 
 Ar 1  is pyridyl, optionally substituted with 1 to 4 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl, methyl, —CF 3 , methoxy, —OCF 3 , methylthio, —SCF 3 ; 
 Ph 1  is phenyl optionally substituted with 1 to 5 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl, methylthio, —SCF 3 , (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; 
 Het 1  is a saturated, nitrogen-containing heterocycle substituent selected from the group consisting of pyrrolidinyl, piperidinyl, homopiperidinyl, morpholinyl, thiomorpholinyl, homomorpholinyl, and homothiomorpholinyl, any of which may optionally be substituted with (C 1 -C 6 )alkyl or with 2 methyl substituents; 
 
       or a pharmaceutically acceptable salt thereof. 
     
     
         2 . A compound of Formula (Ia): 
       
         
           
           
               
               
           
         
       
       wherein
 R 7a  is chloro; and 
 R 10  is
 a) an aromatic heterocycle substituent selected from the group consisting of tetrazolyl 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,3-oxadiazolyl, 1,3,4-oxadiazolyl and 1,2,4-oxadiazolyl any one of which may optionally be substituted with a substituent selected from the group consisting of (C 1 -C 4 )alkyl optionally substituted with 1 to 5 fluoro substituents, Ph 1 -(C 0 -C 3 )alkyl Ar 1 (C 0 -C 3 )alkyl (C 1 -C 4 )alkyl-C(O)—, Ph 1 -(C 0 -C 3 )alkyl-C(O)— Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 1 -C 4 )alkyl-NR 12 —(C 0 -C 3 )alkyl-optionally substituted on the on the and (C 1 -C 4 )alkyl moiety with 1 to 5 fluoro substituents, (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, Ph 1 -(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, Ar 1 —(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl; 
 b) an aromatic heterocycle substituent selected from the group consisting of imidazolyl thiazolyl isothiazolyl thiophenyl pyrazolyl oxazolyl isoxazolyl 1,2,3-triazolyl, 1,2,4-triazolyl or a heterocycle selected from thiazolinyl any one of which may be optionally substituted with one to two substituents selected from the group consisting of
 (C 1 -C 6 )alkyl optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 Ar 1 —(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-C(O)—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—, 
 (C 1 -C 6 )alkyl-NH—C(O)— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, and 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 
  or optionally substituted on ring carbon atoms with one or two substituents selected from the group consisting of
 halo, 
 cyano, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkoxy optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkylthio optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkylthio, 
 (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Ph 1 -(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Ar 1 —(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-C(O)—NH—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—, 
 (C 1 -C 6 )alkyl-O—C(O)—NH— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, and 
 Ar 1 —(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 
  or optionally substituted on two adjacent ring atoms with a bivalent 3 to 4 carbon hydrocarbon substituent which together with the ring atoms to which it is attached form a benzene ring or a partially saturated five- or six-membered ring: 
 c) phenyl optionally substituted with:
 i) 1 to 5 independently selected halo substituents; or 
 ii) 1 to 3 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , nitro, hydroxy (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; or 
 iii) 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, —SCF 3  methyl, —CF 3 , methoxy —OCF 3  nitro, and hydroxy, together with one substituent selected from the group consisting of
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl 
 Ph 1 -(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 5 )alkyl, 
 thiazolyl-(C 0 -C 1 )alkyl optionally substituted with a substituent independently selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, and (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5  alkyl 
 Ph 1 -(C 1 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6  alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 3  alkyl-, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl; 
 
 
 d) an aromatic heterocycle substituent selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, any of which may be optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , methyl —CF 3  methoxy, —OCF 3 , nitro, hydroxy and optionally further substituted with a substituent selected from the group consisting of
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl optionally further substituted on the alkyl moiety with 1 to 6 fluoro substituents and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 Ph 1 -(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 5 )alkyl, 
 thiazolyl-(C 0 -C 1 )alkyl optionally substituted with a substituent independently selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl- optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, and (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 1 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 1 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 5 )alkyl-, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl; or 
 
 e) alpha-naphthalyl, quinolin-2-yl, quinolin-3-yl, or quinolin-4-yl; 
 
 Ar 1  is pyridyl optionally substituted with 1 to 4 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl methyl —CF 3 , methoxy, —OCF 3  methylthio, —SCF 3 ; 
 Ph 1  is phenyl optionally substituted with 1 to 5 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl, methylthio, —SCF 3 , (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents;
 Het 1  is a saturated, nitrogen-containing heterocycle substituent selected from the group consisting of pyrrolidinyl, piperidinyl, homopiperidinyl, morpholinyl, thiomorpholinyl, homomorpholinyl, and homothiomorpholinyl, any of which may optionally be substituted with (C 1 -C 6 )alkyl or with 2 methyl substituents; 
 or a pharmaceutically acceptable salt thereof. 
 
 
     
     
         3 . A compound of Formula (Ib): 
       
         
           
           
               
               
           
         
       
       wherein
 R 7a  is chloro; 
 R 11  is;
 a) phenyl optionally substituted with:
 i) 1 to 5 independently selected halo substituents; or 
 ii) 1 to 3 substituents independently selected from the group consisting of halo, cyano, methyl —CF 3 , —SCF 3  methoxy, nitro, and hydroxy; or 
 iii) 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, methyl —CF 3 , —SCF 3  methoxy, nitro, and hydroxy and further substituted with a substituent selected from the group consisting of:
 (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)-(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 5 )alkyl-, 
 (C 1 -C 6 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, and 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl; 
 
 
 b) pyridyl optionally substituted with
 i) 1 to 3 substituents independently selected from the group consisting of halo, cyano, methyl, —CF 3 , —SCF 3 , methoxy, nitro, and hydroxy; or 
 ii) 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, methyl, —CF 3 , —SCF 3 , methoxy, nitro, and hydroxy and further substituted with a substituent selected from the group consisting of:
 (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally further substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-CH═CH-optionally substituted with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 ) alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl and 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl; 
 
 
 c) pyridazinyl optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, hydroxy (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; and (C 1 -C 6 )alkylthio optionally further substituted with 1 to 6 fluoro substituents; or 
 d) a five-membered aromatic heterocycle selected from the group of thiophenyl, thiazole, isothiazole optionally substituted with 1 or 2 substituents independently selected from the group consisting of halo, cyano, hydroxy, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkylthio optionally further substituted with 1 to 6 fluoro substituents, (C 1 -C 6 )alkylamino optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkyl-C(O)—; 
 
 R 12  is hydrogen or methyl 
 Ar 1  is pyridyl, optionally substituted with 1 to 4 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl, methyl —CF 3 , methoxy, —OCF 3 , methylthio, —SCF 3 ; 
 Ph 1  is phenyl optionally substituted with 1 to 5 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl, methylthio, —SCF 3 , (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; 
 Het 1  is a saturated, nitrogen-containing heterocycle substituent selected from the group consisting of pyrrolidinyl, piperidinyl, homopiperidinyl, morpholinyl, thiomorpholinyl, homomorpholinyl, and homothiomorpholinyl, any of which may optionally be substituted with (C 1 -C 6 )alkyl or with 2 methyl substituents; 
 
       or a pharmaceutically acceptable salt thereof. 
     
     
         4 . A compound of Formula (Ic): 
       
         
           
           
               
               
           
         
       
       wherein
 R 7a  is chloro; 
 R 13  is
 a) phenyl optionally substituted with:
 i) 1 to 5 independently selected halo substituents; or 
 ii) 1 to 3 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , nitro, hydroxy, (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; or 
 iii) 0, 1 or 2 substituents independently selected from the group consisting of halo, cyano, —SCF 3 , methyl —CF 3 , methoxy —OCF 3 , nitro, and hydroxy, together with one substituent selected from the group consisting of
 (C 3 -C 7 )cycloalkyl-(C 0 -C 5 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 Ph 1 -(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents on alkyl and optionally substituted independently on the cycloalkyl moiety with 1 to 6 substituents selected from fluoro and methyl provided that no more than 2 substituents are methyl, 
 (C 1 -C 6 )alkyl-S—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-S—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-O—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-O—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—(C 0 -C 5 )alkyl, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NH—SO 2 —(C 0 -C 5 )alkyl, 
 (C 1 -C 6 )alkyl-SO 2 —NH—(C 0 -C 5 )alkyl, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-SO 2 —NH—(C 1 -C 5 )alkyl; or 
 
 
 b) thiophenyl optionally substituted with one to two substituents selected from the group consisting of
 halo, 
 cyano, 
 (C 1 -C 6 )alkyl optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 Ar 1 —(C 0 -C 3 )alkyl optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkyl-C(O)—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—, 
 (C 1 -C 6 )alkyl-NH—C(O)— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, 
 
 Ar 1 —(C 0 -C 3 )alkyl-NH—C(O)— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents,
 (C 1 -C 6 )alkyl-CH═CH— optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkoxy optionally substituted with 1 to 6 fluoro substituents, 
 (C 1 -C 6 )alkylthio optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkylthio, 
 (C 1 -C 6 )alkyl-NR 12 —(C 0 -C 3 )alkyl-optionally substituted on the (C 1 -C 6 )alkyl moiety with 1 to 6 fluoro substituents, 
 (C 3 -C 7 )cycloalkyl-(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl, 
 Ph 1 -(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 5 )alkyl-, 
 Ar 1 —(C 0 -C 3 )alkyl-NR 12 —(C 0 -C 3 )alkyl-, 
 Het 1 -(C 0 -C 3 )alkyl-, 
 (C 1 -C 6 )alkyl-C(O)—NH—, 
 Ph 1 -(C 0 -C 3 )alkyl-C(O)—NH—, 
 Ar 1 —(C 0 -C 3 )alkyl-C(O)—NH—, 
 (C 1 -C 6 )alkyl-O—C(O)—NH— optionally substituted with 1 to 6 fluoro substituents, 
 Ph 1 -(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents, and 
 Ar 1 —(C 0 -C 3 )alkyl-O—C(O)—NH— optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents; 
 
 
 Ar 1  is pyridyl, optionally substituted with 1 to 4 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl, methyl —CF 3 , methoxy, —OCF 3 , methylthio, —SCF 3 , 
 Ph 1  is phenyl optionally substituted with 1 to 5 independently selected halo substituents, or with 1 to 3 substituents independently selected from the group consisting of halo, cyano, hydroxy, acetyl methylthio, —SCF 3 , (C 1 -C 6 )alkyl optionally further substituted with 1 to 6 fluoro substituents, and (C 1 -C 6 )alkoxy optionally further substituted with 1 to 6 fluoro substituents; 
 Het 1  is a saturated, nitrogen-containing heterocycle substituent selected from the group consisting of pyrrolidinyl, piperidinyl, homopiperidinyl, morpholinyl, thiomorpholinyl, homomorpholinyl, and homothiomorpholinyl, any of which may optionally be substituted with (C 1 -C 6 )alkyl or with 2 methyl substituents; 
 or a pharmaceutically acceptable salt thereof. 
 
     
     
         5 . (canceled) 
     
     
         6 . A pharmaceutical composition comprising a compound according to  claim 1 , or a pharmaceutically acceptable salt thereof, as an active ingredient in association with a pharmaceutically acceptable carrier, diluent or excipient. 
     
     
         7 . (canceled) 
     
     
         8 . A method for the treatment of obesity in mammals, comprising administering to a mammal in need of such treatment an effective amount of a compound according to  claim 1 . 
     
     
         9 . The method of  claim 8 , where the mammal is human. 
     
     
         10 . A method for the treatment of obsessive compulsive disorder in mammals, comprising administering to a mammal in need of such treatment an effective amount of a compound according to  claim 1 . 
     
     
         11 . The method of  claim 10 , where the mammal is human. 
     
     
         12 . A method for the treatment of depression in mammals, comprising administering to a mammal in need of such treatment an effective amount of a compound according to  claim 1 . 
     
     
         13 . The method of  claim 12 , where the mammal is human. 
     
     
         14 . A method for the treatment of anxiety in mammals, comprising administering to a mammal in need of such treatment an effective amount of a compound according to  claim 1 . 
     
     
         15 . The method of  claim 14 , where the mammal is human. 
     
     
         16 - 27 . (canceled)
Cited by (0)

No later patents cite this yet.
References (0)

No backward citations on record.