Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders

Abstract

This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment of alleviation of diseases or disorders associated with, or mediated by a drop in extra cellular pH.

1 - 30 . (canceled) 
     
     
         31 . A compound selected from the group consisting of 
       7-methyl-5-(1-naphthyl)-1-6-7-8-tetrahydrobenzo-[2,1-b:3,4-c]-dipyrrole-2,3-dione-3-oxime; 
       7-ethyl-5-phenyl-1-6-7-8-tetrahydrobenzo-[2,1-b:3,4-c]-dipyrrole-2,3-dione-3-oxime; 
       7-methyl-5-phenyl-1-6-7-8-tetrahydrobenzo-[2,1-b:3,4-c]-dipyrrole-2,3-dione-3-oxime; 
       5-phenyl-6-7-8-9-tetrahydro-1-H-pyrrolo-[3,2-h]-naphthalene-2,3-dione-3-oxim;