US2008274101A1PendingUtilityA1

Stabilizing polypeptides which have been exposed to urea

62
Assignee: EMERY JEFFERSON CPriority: Dec 19, 2001Filed: Jul 10, 2008Published: Nov 6, 2008
Est. expiryDec 19, 2021(expired)· nominal 20-yr term from priority
Inventors:Jefferson C. EmeryPaul J. McdonaldRhona O'Leary
A61P 43/00C07K 16/2863A61K 39/3955A61K 47/18A61K 39/39591C07K 2317/76C07K 16/32C07K 2317/24A61K 47/183C07K 16/065
62
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

Methods for stabilizing polypeptides, such as anti-HER2 antibodies, which have been exposed to urea.

Claims

exact text as granted — not AI-modified
1 . An isolated composition comprising a purified anti-HER2 antibody, and urea and an amino acid added to said antibody. 
     
     
         2 . The composition of  claim 1  wherein the anti-HER2 antibody is monoclonal. 
     
     
         3 . The composition of  claim 2  wherein the anti-HER2 antibody is an antibody fragment. 
     
     
         4 . The composition of  claim 2  wherein purification of the anti-HER2 antibody includes Protein A chromatography. 
     
     
         5 . The composition of  claim 2  which is an aqueous solution. 
     
     
         6 . The composition of  claim 5  which consists essentially of a purified anti-HER2 antibody, urea, an amino acid and water.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.