Use of ACRP30 Globular Head to Promote Increases in Muscle Mass and Muscle Differentiation

Abstract

The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free fatty acids in muscle, useful in methods of treating muscle-related diseases and disorders as well as for augmenting muscle mass in general. The muscle-related diseases or disorders envisaged to be treated by the methods of the invention include, but are not limited to, muscular dystrophy, and other conditions resulting in muscle atrophy or muscle wasting.

1 . A method of accelerating muscle cell differentiation, comprising contacting muscle cells with gOBG3 under conditions wherein said gOBG3 binds to said cells thereby accelerating differentiation of said cells. 
     
     
         2 . The method of  claim 1 , wherein said cells are in an individual. 
     
     
         3 . The method of  claim 2 , wherein said gOBG3 is present in a pharmaceutical composition. 
     
     
         4 . The method of  claim 3 , wherein said gOBG3 is gApm1. 
     
     
         5 . A method of accelerating muscle cell reorganization, comprising contacting muscle cells with, gOBG3 under conditions wherein said gOBG3 binds to said cells thereby accelerating reorganization of said cells. 
     
     
         6 . The method of  claim 5 , wherein said cells are in an individual. 
     
     
         7 . The method of  claim 6 , wherein said gOBG3 is present in a pharmaceutical composition. 
     
     
         8 . The method of  claim 7 , wherein said gOBG3 is gApm1. 
     
     
         9 . A method of increasing muscle mass in an individual, comprising contacting muscle cells in said individual with gOBG3 under conditions wherein said gOBG3 binds to said cells thereby accelerating the reorganization and differentiation of said cells and increasing said muscle mass. 
     
     
         10 . The method of  claim 9 , wherein said gOBG3 is present in a pharmaceutical composition. 
     
     
         11 . The method of  claim 10 , wherein said gOBG3 is gApm1. 
     
     
         12 . A method of treating muscle cell disorders in an individual, comprising contacting muscle cells in said individual with gOBG3 under conditions wherein said gOBG3 binds to said cells thereby accelerating the reorganization and differentiation of said cells, and thereby treating said muscle cell disorders. 
     
     
         13 . The method of  claim 12 , wherein said muscle cell disorders are selected from the group consisting of muscle-related eye disorders, muscle-related recovery after injuries, muscle-related recovery after surgery, muscle-related disorders of aging, muscle atrophy, muscle wasting, and muscular dystrophy. 
     
     
         14 . The method of  claim 13 , wherein said gOBG3 is present in a pharmaceutical composition. 
     
     
         15 . The method of  claim 14 , wherein said gOBG3 is gApm1.