Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process

Abstract

A process for removing viruses in fibrinogen solutions and fibrinogen obtained thereof wherein the process starts with an adjusted purified fibrinogen solution, the adjusted purified solution is frozen and then thawed at a temperature between 5 and 20° C., the undissolved materials associated with the fibrinogen are subsequently separated, the temperature is adjusted and the resultant solution is finally subjected to nanofiltration using filters having a pore size smaller than 35 nm.

1 - 16 . (canceled) 
     
     
         17 . An isolated fibrinogen solution comprising nanofiltered fibrinogen wherein the solution is substantially free of unenveloped viruses having a size between 20 and 30 nm. 
     
     
         18 . An isolated fibrinogen solution comprising nanofiltered fibrinogen wherein the solution is substantially free of insoluble, aggregated, or partially denatured material having a size of 35 nm or greater. 
     
     
         19 . The isolated fibrinogen solution of  claim 17 , comprising at least one amino acid. 
     
     
         20 . The isolated fibrinogen solution of  claim 18 , comprising at least one amino acid.